Results 91 to 100 of about 54,728 (292)

Virtual screening and biological activity evaluation of novel efflux pump inhibitors targeting RE-CmeB in Campylobacter spp.

One Health Advances
RE-CmeABC is a variant of the efflux pump CmeABC in the major zoonotic pathogen Campylobacter, which is much more potent in conferring resistance to various antibiotics for the treatment of Campylobacter infections in both veterinary and medical clinics.
Shihong Li, Cheng Zhang, Wenjun Li, Shuigen Wan, Jin Kang, Yong Liu, Hexiang Huang, Hao Li, Longhua Yang, Yanhong Shang, Chenglong Li, Xiangdang Du, Hong Yao   +12 more
doaj   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Analogues of Disulfides from Allium stipitatum demonstrate potent anti-tubercular activities through drug efflux pump and Biofilm inhibition [PDF]

, 2018
Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethiosulfonate ...
Bhakta, Sanjib, Bhakta, Sanjib, Danquah, Cynthia A., Danquah, Cynthia A., Evangelopoulos, Dimitrios, Evangelopoulos, Dimitrios, Gibbons, Simon, Gibbons, Simon, Kakagianni, Eleftheria, Kakagianni, Eleftheria, Khondkar, Proma, Khondkar, Proma, Maitra, Arundhati, Maitra, Arundhati, Malkinson, John, Malkinson, John, McHugh, Timothy D., McHugh, Timothy D., Rahman, M., Rahman, M., Stapleton, Paul, Stapleton, Paul   +21 more
core   +5 more sources

Recent advances toward a molecular mechanism of efflux pump inhibition

Frontiers in Microbiology, 2015
Multi-drug resistance (MDR) in Gram-negative pathogens, such as the Enterobacteriaceae and Pseudomonas aeruginosa, poses a significant threat to our ability to effectively treat infections caused by these organisms.
Timothy J Opperman, Son T Nguyen
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant bacteria

Journal of Enzyme Inhibition and Medicinal Chemistry
Aminoacyl-tRNA synthetases have been widely exploited as targets for antiparasitic and antifungal inhibitors; however, they have received little attention as targets in multidrug-resistant (MDR) bacteria. Here we describe the biochemical characterisation
Cristiane Tambascia, Jaqueline Cristina Silva, Barbara Carvalho dos Reis, Camila Fernanda Silva Camilo, Carlos Abrunhosa Tairum Junior, Thais Hancio, Valquiria Graia Correia, Ronaldo Aloise Pilli, Andre Schützer de Godoy, Benoît Laleu, Maurício Luís Sforça, Silvana Aparecida Rocco, Celso Eduardo Benedetti, Gustavo Fernando Mercaldi   +13 more
doaj   +1 more source

Clinically Approved Drugs Inhibit the Staphylococcus aureus Multidrug NorA Efflux Pump and Reduce Biofilm Formation

Frontiers in Microbiology, 2019
Staphylococcus aureus has acquired resistance to antibiotics since their first use. The S. aureus protein NorA, an efflux pump belonging to the major facilitator superfamily (MFS), contributes to resistance to fluoroquinolones (e.g., ciprofloxacin ...
Saskia Zimmermann, Saskia Zimmermann, Mareike Klinger-Strobel, Jürgen A. Bohnert, Jürgen A. Bohnert, Sindy Wendler, Jürgen Rödel, Mathias W. Pletz, Bettina Löffler, Bettina Löffler, Lorena Tuchscherr, Lorena Tuchscherr   +11 more
doaj   +1 more source

Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps [PDF]

, 2016
Alpha-tocopherol is one the most abundant and biologically active isoforms of vitamin E. This compound is a potent antioxidant and one of most studied isoforms of vitamin E.
Andrade, Jacqueline C., Balbino, Valdir Q., Braga, Maria Flaviana B.M., Campina, Fábia F., Coutinho, Henrique D.M., do S. Costa, Maria, Leal-Balbino, Tereza C., Limaverde, Paulo W., Morais-Tintino, Cícera D., Pereira, Raimundo L., Quintans-Júnior, Lucindo J., Ribeiro-Filho, Jaime, Siqueira-Junior, José P., Tintino, Saulo R.   +13 more
core   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

The PIN-FORMED (PIN) protein family of auxin transporters [PDF]

, 2009
The PIN-FORMED (PIN) proteins are secondary transporters acting in the efflux of the plant signal molecule auxin from cells. They are asymmetrically localized within cells and their polarity determines the directionality of intercellular auxin flow.
Krecek, Pavel, Skupa, Petr, Libus, Jiri, Naramoto, Satoshi, Tejos Ulloa, Ricardo, Friml, Jiri, Zazimalova, Eva   +6 more
core   +2 more sources