Results 111 to 120 of about 26,521 (248)

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria. [PDF]

Antibiotics (Basel), 2023
Compagne N, Vieira Da Cruz A, Müller RT, Hartkoorn RC, Flipo M, Pos KM.   +5 more
europepmc   +1 more source

Interference of ATP‐Binding Cassette Transporter by Functional Nano‐Delivery System for High Efficiency Management of Insecticide‐Resistant Nilaparvata lugens

Advanced Science, EarlyView.
A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He, Hejun Ren, Shuo Zhang, Jikang Cheng, Hui Zhang, Jiao Liu, Sijie Wang, Congfen Gao, Yanchao Zhang, Yunhao Gao   +9 more
wiley   +1 more source

Evaluation of ellagic acid and gallic acid as efflux pump inhibitors in strains of Staphylococcus aureus. [PDF]

Biol Open, 2022
Macêdo NS, Barbosa CRDS, Bezerra AH, Silveira ZS, da Silva L, Coutinho HDM, Dashti S, Kim B, da Cunha FAB, da Silva MV.   +9 more
europepmc   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies. [PDF]

Int J Mol Sci, 2022
Neves AR, Durães F, Freitas-Silva J, Szemerédi N, Martins-da-Costa P, Pinto E, Correia-da-Silva M, Spengler G, Sousa E.   +8 more
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Evaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria

Scientific Reports
Antimicrobial resistance concerning burdens is increasing day by day. Efflux pump upregulation is one of the mechanisms through which bacteria develop resistance to antibiotics.
Md. Momin-Reza, Rafat Hossain Rafi, Rukunuzzaman Mia, Md. Jonaid Tawfiq, Md. Rafiqul Islam Khan, Md. Omar Faruqe, Sitelbanat Yassin Ehaimir, Md. Abdul Alim Al-Bari   +7 more
doaj   +1 more source

Plant Secondary Metabolites on Efflux-Mediated Antibiotic Resistant Stenotrophomonas Maltophilia: Potential of Herbal-Derived Efflux Pump Inhibitors. [PDF]

Antibiotics (Basel), 2023
Nguyen THT, Nguyen NAT, Nguyen HD, Nguyen TTH, Le MH, Pham MQ, Do HN, Hoang KC, Michalet S, Dijoux-Franca MG, Pham HN.   +10 more
europepmc   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Evaluation of Heterocyclic Carboxamides as Potential Efflux Pump Inhibitors in Pseudomonas aeruginosa. [PDF]

Antibiotics (Basel), 2021
Yuan Y, Rosado-Lugo JD, Zhang Y, Datta P, Sun Y, Cao Y, Banerjee A, Parhi AK.   +7 more
europepmc   +1 more source