Results 121 to 130 of about 147,157 (321)

A Physiological Microfluidic Blood–Brain‐Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation

Advanced Healthcare Materials, EarlyView.
A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen, Neona M. Lowe, Sophia Kellogg, Kuan‐Wei Huang, Hannah O'Toole, Elizabeth J. Hale, Venktesh S. Shirure, Bhupinder S. Shergill, Steven C. George, Randy P. Carney   +9 more
wiley   +1 more source

Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA.

Biophysical Journal, 2019
The overexpression of multidrug efflux pumps is an important mechanism of clinical resistance in Gram-negative bacteria. Recently, four small molecules were discovered that inhibit efflux in Escherichia coli and interact with the AcrAB-TolC efflux pump ...
Z. Darżynkiewicz, A. Green, Narges Abdali, Anthony Hazel, Ronnie L. Fulton, J. Kimball, Z. Gryczynski, J. Gumbart, Jerry M. Parks, Jeremy C. Smith, H. Zgurskaya   +10 more
semanticscholar   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. [PDF]

, 2008
Objective: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCa agonist.
Beuers, U., Denk, G.U., Hohenester, S., Pusl, T., Rust, C., Wimmer, R.   +5 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Anti-infectives in Drug Delivery-Overcoming the Gram-Negative Bacterial Cell Envelope. [PDF]

, 2017
Infectious diseases are becoming a major menace to the state of health worldwide, with difficulties in effective treatment especially of nosocomial infections caused by Gram-negative bacteria being increasingly reported.
A Davin-Regli, A Kumar, AI Kuzmenko, AJ Huh, AP Brun Le, C Danelon, C Peetla, C Rodrigues, CW Mullineaux, D Pornpattananangkul, DI Fernandez, DI Fernandez, E De, E Hajjar, E Mataraci, EL Wu, EM Nestorovich, EM Wellington, F Bambeke Van, FC Tenover, G Fragneto, Gerardino D’Errico, H Cai, H Nikaido, H Nikaido, J Kubiak, J Meng, JL Gornall, JM Pages, JM Pages, JM Pages, K Murzyn, K Naghmouchi, KR Mahendran, KR Pandit, L Wang, LA Clifton, LA Clifton, Laura A. Dever, M Kreir, M Luckey, M McKenna, M Murcia-Soler, M Murcia-Soler, M Palusinska-Szysz, MA Fischbach, MB Miller, MH Xiong, MH Xiong, ML Nelson, MT Cronin, N Modi, N Nafee, NA Berglund, NY Yount, O Ries, P Fillion, PR Singh, R O’Shea, RD Lins, RE Hancock, RE Hancock, S Kascakova, S Nuding, SC Park, SP Chakraborty, T Charitat, T Lemmin, T Mach, T Mach, TD Davis, TE Renau, Thomas J. Walsh, TJ Piggot, TJ Silhavy, W Zhao, YJ Gordon   +76 more
core   +2 more sources

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Efflux Pump Mediated Streptococcus Mutans Resistance To Quaternary Ammonium Salt

International Dental Journal
Aim or purpose: The goals of this study were to explore the mechanisms of Streptococcus mutans (S. mutans) resistance to quaternary ammonium salt (QAS), dimethylaminohexadecyl methacrylate (DMAHDM). Materials and methods: Drug-resistance of S.
Yingxiang Chen, Wen Zhou, Lei Cheng, Hockin HK Xu, Xiaojing Huang, Ke Yang, Zhuoshu Wu   +6 more
doaj   +1 more source

P-glycoprotein and its role in drug-drug interactions [PDF]

, 2014
Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption. Drugs which induce P-glycoprotein, such as rifampicin, can reduce
Finch, Andrew, Pillans, Peter
core   +1 more source

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump.

ACS Infectious Diseases, 2017
Antibiotic resistance is a major threat to human welfare. Inhibitors of multidrug efflux pumps (EPIs) are promising alternative therapeutics that could revive activities of antibiotics and reduce bacterial virulence. Identification of new druggable sites
Narges Abdali, Jerry M. Parks, Keith M Haynes, Julie L. Chaney, A. Green, David Wolloscheck, John K. Walker, V. Rybenkov, J. Baudry, Jeremy C. Smith, H. Zgurskaya   +10 more
semanticscholar   +1 more source