Results 191 to 200 of about 54,728 (292)

From Quinoline to Quinazoline-Based S. aureus NorA Efflux Pump Inhibitors by Coupling a Focused Scaffold Hopping Approach and a Pharmacophore Search. [PDF]

ChemMedChem, 2021
Cedraro N, Cannalire R, Astolfi A, Mangiaterra G, Felicetti T, Vaiasicca S, Cernicchi G, Massari S, Manfroni G, Tabarrini O, Cecchetti V, Barreca ML, Biavasco F, Sabatini S.   +13 more
europepmc   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Repurposed Drugs and Efflux Pump Inhibitors Against Gram-Negative Urinary Tract Pathogenic Bacteria. [PDF]

Antibiotics (Basel)
Kincses A, Nové M, Asefi J, Spengler G.
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Mutations in the proximal binding site and F-loop of AdeJ confer resistance to efflux pump inhibitors. [PDF]

Antimicrob Agents Chemother
Saral Sariyer A, Leus IV, Tambat R, Farjana M, Olvera M, Rukmani SJ, Sariyer E, Smith JC, Parks JM, Walker JK, Zgurskaya HI.   +10 more
europepmc   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Exploring novel amides as efflux pump inhibitors for overcoming antibiotic resistance in multidrug-resistant <i>Pseudomonas aeruginosa</i>. [PDF]

Iran J Microbiol
Ullah F, Ali M, Niaz F, Khan IA, Khan SW, Khan M, Ishaq R, Manan A, Yu Y, Ilyas M.   +9 more
europepmc   +1 more source

The Interplay of Dispersion and Thermal Shock in Pseudomonas Aeruginosa Biofilms

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Pathological bacterial biofilms formed on medical implants pose a significant challenge in clinical settings due to their resistance to antibiotics and the host immune response. Eradication of these biofilms by thermal shock has gained increasing attention as a means of eliminating these infections.
Hossein Zare, Josiah Power, Eric Nuxoll
wiley   +1 more source

An undergraduate experimental research program, involving the screening of efflux pump inhibitors, to improve student research skills in biomedical science. [PDF]

BMC Med Educ
Zong G, Zhang P, Wang Y, Han J, Wang L, Pan J, Pang J, Cao G, Fu J.   +8 more
europepmc   +1 more source