Results 211 to 220 of about 26,521 (248)

Determination of the Efflux Pump-Mediated Resistance Prevalence in Pseudomonas aeruginosa, Using an Efflux Pump Inhibitor

Current Microbiology, 2009
In gram negative bacteria, fluoroquinolone resistance is acquired by target mutations in topoisomerase genes or by reducing the permeation of drugs due to the increase in expression of endogenous multidrug efflux pumps that expel structurally unrelated antimicrobial agents.
Abolghasem, Tohidpour, Shahin, Najar Peerayeh, Jalil F, Mehrabadi, Hadi, Rezaei Yazdi   +3 more
openaire   +2 more sources

Microbial Efflux of Antibiotics and Inhibitors of Efflux Pumps

2014
Detergent-like bile salts kill bacterial cells by destroying bacterial multidrug resistance (MDR) efflux systems. These not only play an important role in antibacterial resistance but also contribute to bacterial pathogenesis. Reserpine and H+/K+ ATPase inhibitors can significantly reduce MICs, increase killing activity, and prolong the postantibiotic ...
openaire   +1 more source

Antimicrobial Drug Efflux Pump Inhibitors

2016
Bacterial multidrug resistance is on the rise, and bacterial efflux pumps make a major contributor to this development. Efflux pump inhibitors (EPIs) may be a solution to this problem, since they can reverse resistance to clinically administered antimicrobial agents. Multiple EPIs with activity against Gram-positive and Gram-negative bacteria have been
Jürgen A. Bohnert, Winfried V. Kern
openaire   +1 more source

The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance

Proceedings of the National Academy of Sciences of the United States of America, 2023
David R Spring, Paul Edelstein, Lalita Ramakrishnan   +2 more
exaly  

Bacterial efflux pump inhibitors

2021
LAVOIE EDMOND J, PARHI AJIT, YUAN YI, ZHANG YONGZHENG, SUN YANGSHENG   +4 more
openaire   +3 more sources

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from Escherichia coli

Biology, 2022
Rawaf Alenazy
exaly  

An Update on Staphylococcus aureus NorA Efflux Pump Inhibitors

Current Topics in Medicinal Chemistry, 2020
Kadja Luana Chagas Monteiro, Thiago Aquino   +1 more
exaly  

Synthesis of potential efflux pump inhibitors

2018
Microorganisms are playing an important role at a global scale, directly affecting the environment. Antimicrobial resistance is a worldwide problem in human and veterinary medicine. It occurs when micro-organisms evolve resistance to antimicrobial substances and seems to be inevitable.
Rudokaitė, Aida, Sutkuvienė, Simona
openaire   +2 more sources

EFFLUX PUMP INHIBITORS

2000
CHAMBERLAND SUZANNE, ISHIDA YOHEI, LEE VING J, LEGER ROGER, NAKAYAMA KIYOSHI, OHTA TOSHIHARU, OHTSUKA MASAMI, RENAU THOMAS E, WATKINS WILLIAM J, ZHANG ZHIJIA J   +9 more
openaire   +5 more sources

Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update

2022
Pallavi Ahirrao, Ritu Kalia, Sanjay M. Jachak   +2 more
openaire   +1 more source