In Vitro and In Vivo Investigations into the Potential of Quinazoline and Quinoline Derivatives as NorA Efflux Pump Inhibitors Against Resistant <i>Staphylococcus aureus</i> Strains. [PDF]
Antibiotics (Basel)Chandal N +7 more
europepmc +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.This work developed a low‐temperature sludge hydrothermal coupled with gel crosslinking strategy which could upgrade the waste liquid generated from sewage sludge hydrothermal treatment into the hydrothermal‐liquid‐gel. The inventive hydrothermal‐liquid‐gel exhibited the enhanced pollutant removal capability, high synthetic stability, and superior ...
Zifan Liu +12 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1183-1193, April 2025.Abstract Aims The prognostic significance of left ventricular (LV) diastolic dysfunction (LVDD) severity in patients with dilated cardiomyopathy (DCM) remains uncertain. This study aimed to evaluate the association of LVDD severity and elevated left atrial pressure (eLAP) with patient outcomes in stable, non‐acutely decompensated patients with DCM ...
Mateusz Winiarczyk +12 more
wiley +1 more source
Biofunctionalization of Poly(lactide-co-glycolic acid) Using Potent NorA Efflux Pump Inhibitors Immobilized on Nanometric Alpha-Zirconium Phosphate to Reduce Biofilm Formation. [PDF]
Materials (Basel), 2021 Pica M +5 more
europepmc +1 more source
Increased calcification by erythrophagocytosis in aortic valvular interstitial cells
ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin +3 more
wiley +1 more source
Enhancing Antibacterial Efficacy: Combining Novel Bacterial Topoisomerase Inhibitors with Efflux Pump Inhibitors and Other Agents Against Gram-Negative Bacteria. [PDF]
Antibiotics (Basel)Zorman M +11 more
europepmc +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Screening and Evaluation of Potential Efflux Pump Inhibitors with a Seaweed Compound Diphenylmethane-Scaffold against Drug-Resistant Escherichia coli. [PDF]
Antibiotics (Basel)Lu WJ +6 more
europepmc +1 more source
Sensitizing multi drug resistant Staphylococcus aureus isolated from surgical site infections to antimicrobials by efflux pump inhibitors. [PDF]
Afr Health Sci, 2020 Baiomy AA, Shaker GH, Abbas HA.
europepmc +1 more source
Considerations for drug trials in hypertrophic cardiomyopathy
ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant +17 more
wiley +1 more source