Results 241 to 250 of about 147,157 (321)

Adherens junction protein expression is associated with poor response to neoadjuvant FLOT chemotherapy and pro‐inflammatory tumor microenvironment in esophageal adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor survival and variable response to perioperative chemotherapy. Although histopathological features correlate with outcomes, the relationship specifically between adherens junction (AJ) protein expression and treatment response in EAC remains uncertain.
Bastian Grothey, Heike Löser, Tillmann Bedau, Wolfgang Schröder, Christiane J. Bruns, Thomas Zander, Max Krämer, Reinhard Büttner, Alexander Quaas   +8 more
wiley   +1 more source

Atrial cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 727-729, April 2025.
Wojciech Kosmala, Monika Przewłocka‐Kosmala   +1 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Magnetocardiography combined with machine learning for pulmonary hypertension detection and improved short‐term risk assessment

Interdisciplinary Medicine, EarlyView.
Magnetocardiography (MCG) enables non‐invasive mapping of cardiac magnetic fields. In this study, an MCG‐based machine learning model detects pulmonary hypertension with robust performance. Furthermore, MCG features may improve the accuracy of short‐term risk assessment.
Yuankun Qi, Jiaqi Liang, Kai Ma, Xiaoyu Hu, Yu Zhang, Xiaole Han, Dong Xu, Xu Zhang, Xiaopei Cui, Min Xiang, Hongyu Zhang, Jiancheng Fang   +11 more
wiley   +1 more source

Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy [PDF]

, 2017
Glupczynski, Y., Pechère, J. C., Plésiat, P., Tulkens, P. M., Van Bambeke, F.   +4 more
core  

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Efflux pumps in Mycobacterium tuberculosis : what is their role in multi-drug resistance? [PDF]

, 2014
Roca Pascual, Núria, Universitat Autònoma de Barcelona. Facultat de Biociències   +1 more
core  

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Phytochemical content, antioxidant and antibacterial properties of Typhonium flagelliforme cultivated via soil and hydroponic methods

JSFA reports, EarlyView.
Abstract Background Typhonium flagelliforme is a medicinal herb in the Araceae family, widely distributed in Southeast Asia. This study aimed to evaluate the effects of hydroponic and soil‐based cultivation systems on the phytochemical content and bioactivity of T. flagelliforme. Results Using liquid chromatography‐mass spectrometry (LC‐MS) analysis, 9
Yen Ning Lee, Norsharina Md Saad, Siti Rokhiyah Ahmad Usuldin, Seetha Jaganathan King, Wee Sim Choo   +4 more
wiley   +1 more source

Prevalence of Esophageal Dysmotility and Reflux in Muscle Tension Dysphonia Patients

The Laryngoscope, EarlyView.
ABSTRACT Objectives Laryngopharyngeal reflux (LPR) contributes to muscle tension dysphonia (MTD); however, symptoms overlap with esophageal dysmotility. Study aims were to determine the prevalence of esophageal disorders among MTD patients and correlate pathologies to patient‐reported outcome measures (PROMs).
Megan Brianne Saltsgaver, Madison Cheung, Theo Covello, Weihai Zhan, Inna A. Husain   +4 more
wiley   +1 more source