Results 51 to 60 of about 170,445 (249)

Fluorescence-Based Flow Sorting in Parallel with Transposon Insertion Site Sequencing Identifies Multidrug Efflux Systems in Acinetobacter baumannii

mBio, 2016
Multidrug efflux pumps provide clinically significant levels of drug resistance in a number of Gram-negative hospital-acquired pathogens. These pathogens frequently carry dozens of genes encoding putative multidrug efflux pumps.
Karl A. Hassan, Amy K. Cain, TaoTao Huang, Qi Liu, Liam D. H. Elbourne, Christine J. Boinett, Anthony J. Brzoska, Liping Li, Martin Ostrowski, Nguyen Thi Khanh Nhu, Tran Do Hoang Nhu, Stephen Baker, Julian Parkhill, Ian T. Paulsen   +13 more
doaj   +1 more source

Efflux pump proteins in antifungal resistance [PDF]

Frontiers in Pharmacology, 2014
It is now well-known that the enhanced expression of ATP binding cassette (ABC) and major facilitator superfamily (MFS) proteins contribute to the development of tolerance to antifungals in yeasts. For example, the azole resistant clinical isolates of the opportunistic human fungal pathogen Candida albicans show an overexpression of Cdr1p and/or ...
Prasad, Rajendra, Rawal, Manpreet K.
openaire   +3 more sources

Coincidence analysis of efflux pumps in the Escherichia coli pangenome

, 2023
Global rates of multi-drug resistance continue to rise, posing a significant challenge in the fight against antimicrobial resistance worldwide. Multi-drug efflux pumps are a significant contributor to this burden.
Shahabuddin, Ammar A., Clover, Rosie; id_orcid, Gifford, Danna R; id_orcid   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the Gram-negative pathogens: Vibrio cholerae and Neisseria gonorrhoeae [PDF]

, 2006
In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in ...
Du, Dijun
core  

Genomic Tools to Investigate Bacterial Drug Efflux Pumps [PDF]

New therapeutics are urgently needed to combat Gram-negative pathogens such as Escherichia coli, yet antibiotic development has been significantly hindered due to intrinsic antimicrobial resistance elements such as efflux pumps. E. coli harbours 35 known
Thompson, Laura
core   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Fighting back against bacterial resistance: Harnessing nanocarrier strategies to counter antibiotic efflux pumps

Next Materials
The global rise of multidrug-resistant (MDR) bacterial infections poses a significant threat to public health, mainly driven by antibiotic efflux pumps that actively expel drugs from bacterial cells and lower intracellular antibiotic concentrations below
Kingsley Chimaeze Mbara, Yvonne Ngcobo, Betty Chivasa, Lethabo Masemola, Refilwe Mashamaite, Kopang Clemendi Mokhetho, Motsi Phuthi, Mandisa Mangisa, Poloko Stephen Kheoane, Shoeshoe Lydia Mokhele, Lorato Mmaoratwe Marakalala, Claudine Mbeb, Rosalinda Pepita Emeyene, Carmen Myrna Leonard, Vuyelwa Jacqueline Tembu, Clemence Tarirai   +15 more
doaj   +1 more source

Efflux Pump-mediated Drug Resistance in Burkholderia

Frontiers in Microbiology, 2015
Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance.
Nicole L Podnecky, Katherine A Rhodes, Katherine A Rhodes, Herbert P Schweizer, Herbert P Schweizer   +4 more
doaj   +1 more source

Determination of efflux activity in Enterococci by Hoechst accumulation assay and the role of zinc oxide nanoparticles in inhibition of this activity

BMC Microbiology, 2022
Background Contribution of efflux pumps in development of antimicrobial resistance has been largely addressed in Gram negative and to a much lesser extent in Gram positive bacteria.
Mohammad Hossein Sobhanipoor, Roya Ahmadrajabi, Hossein Hosseini Nave, Fereshteh Saffari   +3 more
doaj   +1 more source