Results 61 to 70 of about 170,445 (249)
Frontiers in Microbiology, 2023 Efflux pumps function as an advanced defense system against antimicrobials by reducing the concentration of drugs inside the bacteria and extruding the substances outside. Various extraneous substances, including antimicrobials, toxic heavy metals, dyes,
Shiela Chetri
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Structure and mechanism of bacterial tripartite efflux pumps. [PDF]
, 2018 Efflux pumps are membrane proteins which contribute to multi-drug resistance. In Gram-negative bacteria, some of these pumps form complex tripartite assemblies in association with an outer membrane channel and a periplasmic membrane fusion protein. These
core +2 more sources
Advanced Functional Materials, EarlyView.A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee +15 more
wiley +1 more source
Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates
Frontiers in MicrobiologyAntibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza +12 more
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Advanced Healthcare Materials, EarlyView.Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko +7 more
wiley +1 more source
mBio, 2016 For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment ...
Michelle M. C. Buckner +6 more
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Antibiotics, 2022 Bacterial efflux pumps are among the key mechanisms of resistance against antibiotics and biocides. We investigated whether differential expression levels of the RND-type efflux pumps AdeABC and AdeIJK impacted the susceptibility to commonly used ...
Christina Meyer +6 more
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The MRP family of drug efflux pumps [PDF]
Oncogene, 2003 The MRP family is comprised of nine related ABC transporters that are able to transport structurally diverse lipophilic anions and function as drug efflux pumps. Investigations of this family have provided insights not only into cellular resistance mechanisms associated with natural product chemotherapeutic agents, antifolates and nucleotide analogs ...
Gary D, Kruh, Martin G, Belinsky
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Genes encoding multidrug efflux pumps in strain SWMUKG01.
, 2019 Genes encoding multidrug efflux pumps in strain SWMUKG01.
Yan Gao (93649) +10 more
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Advanced Materials, EarlyView.Development of a novel method for synthesizing Ni single atom catalysts for highly selective electrochemical CO2 reduction in situ. This catalyst achieves 100% selectivity for CO and is formed in an industrially relevant cell architecture. Using post‐mortem XRD, STEM, and EDS and operando XAS, the identity of the active site and the mechanism behind ...
Ian Street +5 more
wiley +1 more source