Results 111 to 120 of about 85,671 (296)

Restoration of Antibiotic Effectiveness with P. hartigii Extract Against Multidrug-Resistant E. coli 

Medical Sciences Forum
Antibiotic resistance poses a critical threat to global health, largely driven by bacterial efflux pumps that expel antibiotics and reduce their efficacy.
Eda Altınöz, Ilgaz Akata, Ergin Murat Altuner   +2 more
doaj   +1 more source

Exploring the cellular accumulation of metal complexes [PDF]

, 2010
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell.
Barton, Jacqueline K., Ernst, Russell J., Puckett, Cindy A.   +2 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Molecular similarity of MDR inhibitors [PDF]

, 2004
Everyone is free to re-use the published material if proper accreditation/citation of the original publication is given. http://creativecommons.org/licences/by/3.0/The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the ...
Gibbons, S., Zloh, Mire
core   +2 more sources

Efflux Pumps and These Inhibitors

VNU Journal of Science: Medical and Pharmaceutical Sciences, 2019
 In this era of multi-drug resistance, efflux pump is one of the major problems which is increasingly concerned by scientists. The structure and mechanism activity of the efflux pumps on both bacteria and eurakyotes that are gradually being clarified. Since then, efflux pump inhibitors have also been studied and initially applied in clinic, that makes ...
Le Minh Tri, Nguyen Hoang Minh, Hoang Tung, Do Tran Giang Son, Phan Thien Vy, Tran Thanh Dao, Thai Khac Minh   +6 more
openaire   +2 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Management of imatinib-resistant CML patients [PDF]

, 2007
Imatinib has had marked impact on outcomes in chronic myelogenous leukemia (CML) patients for all stages of the disease and is endorsed by international treatment guidelines as the first line option.
Branford S, Burger H, Burgess MR, Cortes J, Crossman LC, Donato NJ, Druker BJ, Gambacorti-Passerini C, Giles F, Hochhaus A, Hughes TP, Iacobucci I, Kantarjian H, Lahaye T, Mahon FX, Melo JV, O'Hare T, Quintas-Cardama A, Rousselot P, Sleijfer S, Soverini S, Weisberg E   +21 more
core   +1 more source

Controllable Dynamic Mechanical Cell Stimulation using Magnetically Actuated Artificial Cilia

Advanced Healthcare Materials, EarlyView.
This paper introduces a platform based on magnetic artificial cilia for providing controllable dynamic mechanical stimulation to single cells, suitable for investigating large cell populations and enabling live cell imaging. Proof‐of‐principle experiments show that cell morphology is strongly influenced by the artificial cilia, that cellular forces can
Roel Kooi, Tanveer Ul Islam, Oscar M.J.A. Stassen, Naomie Amsing, Jan de Boer, Jaap M.J. den Toonder   +5 more
wiley   +1 more source

ARCADE: Absolute Radiometer for Cosmology, Astrophysics, and Diffuse Emission [PDF]

, 2006
The Absolute Radiometer for Cosmology, Astrophysics, and Diffuse Emission (ARCADE) is a balloon-borne instrument designed to measure the temperature of the cosmic microwave background at centimeter wavelengths.
A. Kogut, Bartlett, Burigana, Burigana, D. Fixsen, E. Wollack, Fixsen, Fixsen, Fixsen, Fixsen, Fornengo, Gnedin, Gush, Haiman, J. Singal, Jungman, Kogut, Kogut, L. Lowe, M. Limon, M. Seiffert, Mather, Oh, P. Lubin, P. Mirel, S. Fixsen, S. Levin, Singal, Sunyaev, Valle, Zeld´ovich   +30 more
core   +2 more sources

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

Anticancer research, 2012
Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well ...
Amaral, Leonard, Spengler, Gabriella, Martins, Ana, Armada, Ana, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna, Molnar, Joseph   +6 more
openaire   +2 more sources