Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
Frontiers in Microbiology, 2021 Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance (MDR). Postgenomic analysis has demonstrated that numerous multidrug
Martijn Zwama +2 more
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How resistance-nodulation-division (RND) efflux pumps contribute to virulence. [PDF]
PLoS PathogensIn Gram-negative bacteria, multi-subunit efflux pumps transport molecules across the inner membrane, periplasm, and outer membrane to the extracellular environment.
Corrella S Detweiler, Ilyas Alav
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Biofilm Formation and the Role of Efflux Pumps in ESKAPE Pathogens [PDF]
MicroorganismsNosocomial infections caused by ESKAPE pathogens represent a significant burden to global health. These pathogens may exhibit multidrug resistance (MDR) mechanisms, of which mechanisms such as efflux pumps and biofilm formation are gaining significant ...
Trent R. Sorenson +2 more
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Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants
Microorganisms, 2016 Bacterial multidrug efflux pumps are antibiotic resistance determinants present in all microorganisms. With few exceptions, they are chromosomally encoded and present a conserved organization both at the genetic and at the protein levels.
Alejandra Bernardini +2 more
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Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Antibiotics, 2022 Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial ...
Xu Wang, Menghong Dai, Haihong Hao
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Dynamics associated with the efflux pumps in biofilms and persister cells of Cryptococcus neoformans and Cryptococcus gattii [PDF]
Microbiology SpectrumCryptococcosis is a systemic mycosis affecting immunocompromised individuals (mainly C. neoformans) and immunocompetent hosts (mainly C. gattii). Effective treatment remains challenging due to antifungal resistance, driven by efflux pumps, target enzyme ...
Gabriel Rezende Pimenta +6 more
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Flavonoids as Inhibitors of Bacterial Efflux Pumps [PDF]
Molecules, 2021 Flavonoids are widely occurring secondary plant constituents, and are abundant in vegetable and fruit diets as well as herbal medicines. Therapeutic treatment options for bacterial infections are limited due to the spread of antimicrobial resistances.
Franz Bucar
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Functional interplay between RND efflux pumps and GacS in Pseudomonas aeruginosa [PDF]
Applied and Environmental MicrobiologyPseudomonas aeruginosa is an opportunistic human pathogen that is ubiquitous in the environment. The environmental versatility of P. aeruginosa is often attributed to a large arsenal of active efflux pumps, low permeability of the outer membrane, and ...
Justyna W. Adamiak +6 more
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Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates [PDF]
Frontiers in MicrobiologyAntibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates
Léna Mazza +12 more
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Efflux pumps and microbial biofilm formation
Infection, Genetics and Evolution, 2023 Biofilm-related infections are resistant forms of pathogens that are regarded as a medical problem, particularly due to the spread of multiple drug resistance. One of the factors associated with biofilm drug resistance is the presence of various types of efflux pumps in bacteria.
Kafil Hs
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