Results 171 to 180 of about 85,671 (296)

Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant bacteria. [PDF]

J Enzyme Inhib Med Chem
Tambascia C, Silva JC, Dos Reis BC, Camilo CFS, Tairum Junior CA, Hancio T, Correia VG, Pilli RA, de Godoy AS, Laleu B, Sforça ML, Rocco SA, Benedetti CE, Mercaldi GF.   +13 more
europepmc   +1 more source

Multidrug efflux pumps and innate azole resistance of Mucor lusitanicus. [PDF]

J Antimicrob Chemother
Toepfer S, Lamping E, James JE, Zenz LM, Loacker-Schoech J, Rosam K, Majer O, Lackner M.   +7 more
europepmc   +1 more source

A Novel Gain‐of‐Function ITPR1 Variant Associated With a Movement Disorder Characterized by Tremor and Dystonia

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The 1,4,5‐trisphosphate receptor type 1 (ITPR1) gene encodes an endoplasmic reticulum calcium release channel, in which loss‐of‐function mutations have been associated with spinocerebellar ataxias and related neurological phenotypes. Only one gain‐of‐function mutation in the highly conserved suppressor domain of ITPR1 has been previously ...
Emilie T. Théberge, Bo Sun, Ruiwu Wang, Arezoo Mohajeri, Clara D. M. Van Karnebeek, Cornelius F. Boerkoel, Stephanie Huynh, Gabriella Horvath, S. R. Wayne Chen, Anna Lehman   +9 more
wiley   +1 more source

Beyond antibiotic resistance: evidence for resistance-nodulation-division (RND) efflux pumps as virulence determinants. [PDF]

Microbiol Mol Biol Rev
Detweiler CS, Alav I.
europepmc   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Isovolumic relaxation strain imaging is an accurate and sensitive approach for detection of active diastolic dysfunction: A preclinical study

Animal Models and Experimental Medicine, EarlyView.
A modified approach was developed to accurately identify the isovolumetric relaxation time (IVRT) using an apical three‐chamber view. Compared with conventional echocardiography, isovolumic relaxation strain imaging (IVSI) helps to detect the earlier alternations of diastolic function in transverse aortic constriction (TAC) mice.
Jingjing Liang, Juncheng Wang, Jun Cheng, Yanggan Wang   +3 more
wiley   +1 more source

Imipenem-Induced Transcriptional Responses of Porin, Efflux Pumps, and Carbapenemase Genes in Clinical Carbapenem-Resistant <i>Acinetobacter baumannii</i>. [PDF]

Antibiotics (Basel)
Rizvanoglu SS, Karaca B, Eryilmaz M.
europepmc   +1 more source

Optimization and verification of high‐fat diet formulation for establishing a rat model of obesity‐related precocious puberty

Animal Models and Experimental Medicine, EarlyView.
We identified 45% HFD as the optimal formulation to establish a juvenile rat model of obesity‐related precocious puberty. It elicits robust phenotypic (early vaginal opening, obesity), histological (advanced ovarian development), and endocrine (elevated HPG axis hormones) alterations, with leptin‐mediated GnRH secretion as a core mechanistic driver ...
Jiayi Gong, Wei Qian, Deji Song, Kang Li, Li Zhang, Li Shi   +5 more
wiley   +1 more source

Dual-targeting sulfamethoxazole derivatives overcome multidrug resistance in ESKAPE pathogens by inhibiting quorum sensing and efflux pumps. [PDF]

RSC Adv
Adzah BY, Biniyam PD, Ohene-Adu V, Osei M, Adu-Adjei K, Elmes V, Goodall I, Faustina V, Agboyibor YD, Gyan P, Quansah P, Amengor CM, Boateng J, Zhang E, Ampomah-Wireko M, Oyeh E, Kodjo Amengor CD.   +16 more
europepmc   +1 more source

Time‐course characterization of intraocular pressure in murine steroid‐induced ocular hypertension: Effects of route, schedule, and concentration

Animal Models and Experimental Medicine, EarlyView.
Steroid‐induced ocular hypertension is a useful mouse model for glaucoma, but published work rarely quantifies how route, dose, and schedule shape the intraocular pressure (IOP) time‐course—hindering reproducibility and forcing labs to pilot protocols.
Nicholas Y. Q. Tan, Sai Bo Bo Tun, Hla Myint Htoon, Veluchamy Amutha Barathi, Tina T. Wong   +4 more
wiley   +1 more source