Results 101 to 110 of about 447,577 (315)

Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser Endomicroscopy in Squamous Cell Carcinoma of the Head and Neck

Nanomaterials, 2019
Intraoperative definition of tumor free resection margins in head and neck cancer is challenging. In the current proof-of-principle study we evaluated a novel silica nanoparticle-based agent for its potential use as contrast enhancer.
Anna Watermann, Rita Gieringer, Anna-Maria Bauer, Sven Kurch, Ralf Kiesslich, Wolfgang Tremel, Jan Gosepath, Juergen Brieger   +7 more
doaj   +1 more source

Combination of EGFR-TKIs with chemotherapy versus chemotherapy or EGFR-TKIs alone in advanced NSCLC patients with EGFR mutation

, 2018
Miaomiao Wen,1 Jinghua Xia,1 Ying Sun,1 Xuejiao Wang,1 Xianghui Fu,2 Yanning Zhang,1 Zhipei Zhang,1 Yongan Zhou,1 Xiaofei Li1 1Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi, China ...
Li X, Xia J, Wen M, Zhang Z, Fu X, Zhang Y, Wang X, Zhou Y, Sun Y   +8 more
core  

EGF receptor-targeted synthetic double-stranded RNA eliminates glioblastoma, breast cancer, and adenocarcinoma tumors in mice [PDF]

, 2005
Background: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer. With the available treatments, survival does not exceed 12–14 mo from the time of diagnosis.
Levitzki, Alexander, Alexander Levitzki (32255), Shir Alexei, Levitzki Alexander, Manfred Ogris, Ernst Wagner (60760), Wagner, Ernst, Ernst Wagner, Ogris Manfred, Alexander Levitzki, Ogris, Manfred, Manfred Ogris (60759), Alexei Shir (60758), Shir, Alexei, Wagner Ernst, Alexei Shir   +15 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Egfr Intron 1 Dinucleotide Repeat Polymorphism Is Associated with the Occurrence of Skin Rash with Gefitinib Treatment

, 2011
Skin rash is the most common toxicity of epidermal growth factor receptor (EGFR)-targeted therapy. This study investigated the clinical and genetic factors associated with this skin rash. Methods: Fifty-two non-small cell lung cancer patients enrolled in
黃敬倫;楊志新;葉坤輝;胡賦强;陳冠宇;施金元;林宗哲;余忠仁;鄭安理;楊泮池, HUANG, CHING-LUN;YANG, CHIH-HSIN;YEH, KUN-HUEI;HU, FU-CHANG;CHEN, KUAN-YU;SHIH, JIN-YUAN;LIN, ZONG-ZHE;YU, CHONG-JEN;CHENG, ANN-LII;YANG, PAN-CHYR   +1 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Gallic Acid Impedes Non-Small Cell Lung Cancer Progression via Suppression of EGFR-Dependent CARM1-PELP1 Complex

Drug Design, Development and Therapy, 2020
Dong Wang,1 Burenbatu Bao2 1Department of Oncology of Mongolian-Western Medicine, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028007, People’s Republic of China; 2Department of Mongolian Medicine Hematology & ...
Wang D, Bao B
doaj  

EGFR and EGFR ligands in serum in healthy women; reference intervals and age dependency

Clinical Chemistry and Laboratory Medicine (CCLM), 2019
Abstract Background The epidermal growth factor receptor (EGFR) system is involved in cancer pathogenesis and serves as an important target for multiple cancer treatments. EGFR and its ligands epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF), betacellulin (BTC ...
Ina Mathilde Kjær, Dorte Aalund Olsen, Anne Alnor, Ivan Brandslund, Troels Bechmann, Jonna Skov Madsen   +5 more
openaire   +3 more sources