Results 141 to 150 of about 741,060 (264)
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Proliferative and survival pathways in oesophageal cancer [PDF]
, 2011 Includes abstract.Includes bibliographical references.Oesophageal squamous cell carcinoma (OSCC) is the 8th most common cancer worldwide with high incidence in areas that include China, Iran and South Africa. The current treatment available for OSCC does
Esau, Luke Emmanuel
core
Advanced Science, EarlyView.VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho +6 more
wiley +1 more source
, 2018 Rui Zhang,1,* Bojiang Chen,1,* Xiang Tong,1 Ye Wang,1,2 Chengdi Wang,1 Jing Jin,1 Panwen Tian,1,2 Weimin Li1 1Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China;
Li W +7 more
core
Advanced Science, EarlyView.This study systematically assessed the global burden and temporal trends of EOTBL cancer in individuals aged 15–49 years. Smoking, ambient particulate matter pollution, and secondhand smoke remain dominant risk factors. Countries within the same Human Development Index (HDI) category exhibit distinct epidemiological trajectories, underscoring the need ...
Ye Tian +8 more
wiley +1 more source
Philippine Journal of Pathology, 2018 Background. Epidermal Growth Factor Receptor (EGFR) mutation status has been shown to have a significant prognostic and predictive role in the management of Non-small Cell Lung Carcinoma (NSCLC), significantly prolonging patients' survival.
Cyril Kim Nee-Estuye-Evangelista +2 more
doaj
Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma
Advanced Science, EarlyView.Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul +4 more
wiley +1 more source
Advanced Science, EarlyView.Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang +9 more
wiley +1 more source
The predominant EGFR mutation for each group reported by the cobas EGFR test.
The predominant EGFR mutation for each group reported by the cobas EGFR test.
Jason Lai (44092) +14 more
core +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source