Results 141 to 150 of about 1,011 (214)

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Systematic Review and Meta‐Analysis: Plant‐Based Therapy for Irritable Bowel Syndrome

Phytotherapy Research, EarlyView.
ABSTRACT Irritable bowel syndrome (IBS) is a common disorder of brain‐gut interaction that presents with abdominal pain, bloating associated with variable stool consistency. Many IBS patients prefer plant‐based preparations to pharmacological therapy; however, the utility of this approach is not well established.
Anselm Meyer, Jonas Auer, Lorena Cascant‐Ortolano, Niclas Schreiber, Amy Zimmermann‐Klemd, Carsten Gründemann, Philipp Busche, Jörg Schirra, Mark R. Fox   +8 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Mechanochemically Programmed, Oligomer‐Selective Amyloid Assembly via Axial Rotation

Small, EarlyView.
Tunable axial rotation mechanically redirects amyloid assembly without chemical additives. Low rotational speeds favor fibril maturation, whereas high‐speed rotation suppresses productive fibril amplification and biases the pathway toward oligomer‐enriched assemblies.
Seokbeom Roh, Eunji Song, Minwoo Bae, Da Yeon Cheong, Sechan Han, Taeha Lee, Dain Kang, Jae Eon Lee, Seung Pil Pack, Hyungbeen Lee, Insu Park, Gyudo Lee   +11 more
wiley   +1 more source

Programmable Chirality Transfer: Seeding‐Directed Co‐Assembly of Functional Molecules With Amyloid Frameworks

Small, EarlyView.
Seeding‐directed co‐assembly enables efficient chirality transfer from chiral amyloid scaffold to achiral functional molecules. Controlled assembly pathways result in hierarchical hybrid supramolecular structures showing enhanced induced electronic circular dichroism (IECD) and/or vibrational circular dichroism (IVCD).
Aleksandra Kołodziejczyk, Joanna Mazurkiewicz, Andrzej J. Kałka, Agnieszka Kaczor   +3 more
wiley   +1 more source

Revisiting small‐molecule fluorescent probes in food freshness detection

Smart Molecules, EarlyView.
Fluorescent probes serve as versatile tools for food freshness monitoring. This review summarizes recent advances in probes targeting biogenic amines, hydrogen sulfide, pH values, and other key spoilage markers, highlighting their design principles, sensing mechanisms, and practical applications in food quality monitoring. Abstract Food spoilage driven
Xinrui Wang, Zhao Wang, Jingwen Zou, Xuyuan Jiang, Changyu Bian, Zhiqiang Mao   +5 more
wiley   +1 more source

Environmental Contaminant Accumulation in Freshwater Turtles Inhabiting Three Rivers of the Permian Basin, New Mexico, USA

Environmental Toxicology, EarlyView.
ABSTRACT Freshwater turtles are valuable sentinels of aquatic systems due to their long lifespans and resilience in environments impacted by contaminants. The Permian Basin, dominated by the oil and gas sector, spans western Texas and southeastern New Mexico, USA, including the Pecos River and its tributaries, the Delaware and Black Rivers.
Ana G. G. Sapp, W. Gregory Cope, Christopher E. Moorman, Frank X. Weber, Ivana Mali   +4 more
wiley   +1 more source

Environmentally Realistic Metal Mixture Concentration Impacts Early Development in Zebrafish Larvae

Environmental Toxicology, EarlyView.
ABSTRACT The dispersion of metals in the environment leads to the presence of metal mixtures in impacted ecosystems, but few studies have addressed their impact on early developmental processes in fish. Here, we investigated the effect of metal mixtures reported in the Doce River basin in Brazil, including Fe, Mn, and Cd, either singly or as a mixture ...
Anderson K. S. Macêdo, Willian A. Thompson, Hélio B. Santos, Ralph G. Thomé, Mathilakath M. Vijayan   +4 more
wiley   +1 more source

Influence of Age and Exposure Pathway on Copper and Cadmium Mixture Toxicity: A Study on Daphnia magna

Environmental Toxicology, EarlyView.
ABSTRACT Metal contamination in aquatic ecosystems poses substantial risks to freshwater organisms, with mixture effects often deviating from predictions based on single‐metal toxicity. Understanding how age‐specific sensitivities and multiple exposure pathways influence mixture effects is critical for accurate risk assessment.
Sanah Majid, Karen Smeets, Mubiana K. Valentine, Ronny Blust   +3 more
wiley   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly, Andrew Barrick, Tham C. Hoang, Ramon Lavado   +3 more
wiley   +1 more source