Results 211 to 220 of about 48,176 (297)

Baculoviruses exploit the mitotic kinase CDK1 to disrupt the nuclear lamina. [PDF]

PLoS Pathog
Mo M, Yu S, Yang Y, Liu J, Yang K, Yuan M.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model. [PDF]

EMBO Mol Med
Long RKM, Korbmacher F, Ronchi P, Fleckenstein H, Schorb M, Mirza W, Mallorquí M, Aguilar R, Moncunill G, Schwab Y, Bernabeu M.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus. [PDF]

Sci Adv
Braet SM, Venkatakrishnan V, Ramesh R, Clawson MA, Laremore TN, Wong SM, Anand GS.   +6 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Microfluidic platform for automatic quantification of malaria parasite invasion under physiological flow conditions.

Lab Chip
Kals E, Kals M, Introini V, Vodenicharski B, Kotar J, Rayner JC, Cicuta P.   +6 more
europepmc   +1 more source

A novel 2-piperazino-pyrimidine compound exhibits asexual antimalarial activity by targeting Plasmodium falciparum plasmepsin X. [PDF]

Int J Parasitol Drugs Drug Resist
Hong J, Sakura T, Asada N, Fuchino K, Kuwana D, Kaki R, Ishii R, Kato T, Kita K, Matsumura K, Inaoka DK.   +10 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source