Results 1 to 10 of about 6,434 (146)

Ehrlichia chaffeensis Co-Opts Phagocytic Hemocytes for Systemic Dissemination in the Lone Star Tick, Amblyomma americanum [PDF]

Journal of Innate Immunity, 2023
Introduction: Hematophagous arthropods can acquire and transmit several pathogens of medical importance. In ticks, the innate immune system is crucial in the outcome between vector-pathogen interaction and overall vector competence. However, the specific
Abdulsalam Adegoke, Julia Hanson, Ryan C. Smith, Shahid Karim   +3 more
doaj   +2 more sources

Antibody reactive immunomes of Ehrlichia chaffeensis and E. canis are diverse and defined by conformational antigenic determinants [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
For decades, the defined antibody reactive proteins of Ehrlichia chaffeensis and E. canis were limited to a small group with linear antibody epitopes.
Tian Luo, Jignesh G. Patel, Xiaofeng Zhang, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride, Jere W. McBride   +7 more
doaj   +2 more sources

Efficacy and Immune Correlates of OMP-1B and VirB2-4 Vaccines for Protection of Dogs from Tick Transmission of Ehrlichia chaffeensis [PDF]

mBio, 2022
Ehrlichia chaffeensis, an obligatory intracellular bacterium, causes human monocytic ehrlichiosis, an emerging disease transmitted by the Lone Star tick, Amblyomma americanum. Here, we investigated the vaccine potential of OMP-1B and VirB2-4.
Khemraj Budachetri, Mingqun Lin, Rory C. Chien, Wenqing Zhang, Guy Nathaniel Brock, Yasuko Rikihisa   +5 more
doaj   +2 more sources

Glutathione Synthesis Regulated by CtrA Protects Ehrlichia chaffeensis From Host Cell Oxidative Stress [PDF]

Frontiers in Microbiology, 2022
Ehrlichia chaffeensis, a small Gram-negative obligatory intracellular bacterium, infects human monocytes or macrophages, and causes human monocytic ehrlichiosis, one of the most prevalent, life-threatening emerging zoonoses.
Jiaqi Yan, Qi’an Liang, Zhouyi Chai, Nan Duan, Xiaoxiao Li, Yajing Liu, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng   +11 more
doaj   +2 more sources

The “Biological Weapons” of Ehrlichia chaffeensis: Novel Molecules and Mechanisms to Subjugate Host Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging, potentially fatal tick-borne infectious disease.
Yasuko Rikihisa
doaj   +2 more sources

Vaccination with an Attenuated Mutant of Ehrlichia chaffeensis Induces Pathogen-Specific CD4+ T Cell Immunity and Protection from Tick-Transmitted Wild-Type Challenge in the Canine Host. [PDF]

PLoS ONE, 2016
Ehrlichia chaffeensis is a tick-borne rickettsial pathogen and the causative agent of human monocytic ehrlichiosis. Transmitted by the Amblyomma americanum tick, E.
Jodi L McGill, Arathy D S Nair, Chuanmin Cheng, Rachel A Rusk, Deborah C Jaworski, Roman R Ganta   +5 more
doaj   +11 more sources

Transmission of Ehrlichia chaffeensis From an Organ Donor to a Kidney-Pancreas Transplant Recipient. [PDF]

Transpl Infect Dis
Transplant Infectious Disease, Volume 27, Issue 5, September/October 2025.
Gundelly P, Ransom E, Stewart Z, Ruch B, Jittirat A, Denny L, Kasten J, Taylor ML, Salzer JS, Basavaraju SV, Annambhotla P, McCormick DW, Gleaton AN, Karpathy SE, Singleton J, Ramos C, Paddock CD, Rothfeldt LK, Baker M, Villalba JA.   +19 more
europepmc   +2 more sources

Mutations in Ehrlichia chaffeensis Causing Polar Effects in Gene Expression and Differential Host Specificities. [PDF]

PLoS ONE, 2015
Ehrlichia chaffeensis, a tick-borne rickettsial, is responsible for human monocytic ehrlichiosis. In this study, we assessed E. chaffeensis insertion mutations impacting the transcription of genes near the insertion sites.
Chuanmin Cheng, Arathy D S Nair, Deborah C Jaworski, Roman R Ganta   +3 more
doaj   +5 more sources

CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance to Ehrlichia chaffeensis [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis (HME), is a Gram-negative obligatory intracellular bacterium, which infects and multiplies in human monocytes and macrophages.
Qi’an Liang, Jiaqi Yan, Shuwen Zhang, Nan Yang, Meifang Li, Yongxin Jin, Fang Bai, Weihui Wu, Zhihui Cheng   +8 more
doaj   +2 more sources

Ehrlichia chaffeensis Uses an Invasin To Suppress Reactive Oxygen Species Generation by Macrophages via CD147-Dependent Inhibition of Vav1 To Block Rac1 Activation [PDF]

mBio, 2020
The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most factors that could respond to oxidative stress (a host cell defense mechanism).
Omid Teymournejad, Yasuko Rikihisa
doaj   +2 more sources