Results 161 to 170 of about 21,239,713 (204)

EHV-1 glycoprotein D (EHV-1 gD) is required for virus entry and cell-cell fusion, and an EHV-1 gD deletion mutant induces a protective immune response in mice

Archives of Virology, 2000
Insertional mutagenesis was used to construct an equine herpesvirus 1 (EHV-1) mutant in which the open reading frame for glycoprotein D was replaced by a lacZ cassette. This gD deletion mutant (delta gD EHV-1) was unable to infect normally permissive RK cells in culture, but could be propagated in an EHV-1 gD-expressing cell line (RK/gD ...
H, Csellner, C, Walker, J E, Wellington, L E, McLure, D N, Love, J M, Whalley   +5 more
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Protective effects of equine herpesvirus-1 (EHV-1) glycoprotein B in a murine model of EHV-1-induced abortion

Veterinary Microbiology, 1998
In an attempt to determine if pregnant mice could be protected from abortion subsequent to challenge with equine herpesvirus-1 (EHV-1) in the mouse model of EHV-1 disease, female BALB/c mice were inoculated with baculovirus-expressed EHV-1 glycoprotein B (bac-gB), wild-type baculovirus (bac-wt), rabbit kidney (RK-13) or baby hamster kidney (BHK-21 ...
A, Kukreja, C, Walker, T, Fitzmaurice, A, Awan, D N, Love, J M, Whalley, H J, Field   +6 more
openaire   +2 more sources

Equine alphaherpesviruses (EHV-1 and EHV-4) differ in their efficiency to infect mononuclear cells during early steps of infection in nasal mucosal explants

Veterinary Microbiology, 2011
International audienceEquine herpesvirus type 1 (EHV-1) replicates extensively in the epithelium of the upper respiratory tract, after which it can spread throughout the body via a cell-associated viremia in mononuclear leukocytes reaching the pregnant ...
Annelies P Vandekerckhove, Nikolaus Osterrieder, Gerlinde R Van De Walle   +2 more
exaly   +2 more sources

A murine model for studying EHV-1-induced abortion

Research in Veterinary Science, 1991
Balb/c mice were infected with two abortigenic strains of equine herpesvirus-1 (EHV-1) by intranasal inoculation. The inoculation of one strain produced subclinical disease while the other produced a disease characterised by weight loss, constitutional signs, and death in the most severely affected animals.
A R, Awan, J S, Gibson, H J, Field
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Fatal Nonneurological EHV-1 Infection in a Yearling Filly

Veterinary Pathology, 2000
A case of fatal nonneurological equine herpesvirus 1 (EHV-1) infection in a yearling filly is described. Gross lesions included extensive pulmonary edema, prominent laryngeal lymphoid follicles, and congestion and edema of the dorsal third ventricle choroid plexus.
F, Del Piero, P A, Wilkins, P J, Timoney, J, Kadushin, H, Vogelbacker, J W, Lee, S J, Berkowitz, K M, La Perle   +7 more
openaire   +2 more sources

DNA-mediated immunization with glycoprotein D of equine herpesvirus 1 (EHV-1) in a murine model of EHV-1 respiratory infection

Vaccine, 1999
DNA-mediated immunization was assessed in a murine model of equine herpesvirus 1 (EHV-1) respiratory infection. A single intramuscular injection with plasmid DNA encoding EHV-1 glycoprotein D (EHV-1 gD), including its predicted C-terminal membrane anchor sequence, induced a specific antibody response detectable by 2 weeks and maintained through 23 ...
K M, Ruitenberg, C, Walker, J E, Wellington, D N, Love, J M, Whalley   +4 more
openaire   +2 more sources

Protective immunity against equine herpesvirus type-1 (EHV-1) infection in mice induced by recombinant EHV-1 gD

Virus Research, 1998
The ability of recombinant preparations of equine herpesvirus type 1 (EHV-1) glycoprotein D (gD) to elicit specific antibody and T lymphocyte responses in the BALB/c mouse model of respiratory infection was investigated. Recombinant gD (rgD) expressed as a glutathione-S-transferase (GST) fusion protein in Escherichia coli elicited both high titer ...
Y, Zhang, P M, Smith, E B, Tarbet, N, Osterrieder, S R, Jennings, D J, O'Callaghan   +5 more
openaire   +2 more sources

Control of EHV-1 viremia and nasal shedding by commercial vaccines

Vaccine, 2010
Equine herpesvirus-1 is a cause of outbreaks of abortion and neurological disease. The pathogenesis of both these diseases depends on establishment of viremia. An experiment was performed to determine the protective efficacy of two commercially available vaccines used with an optimized 3-dose vaccination regime: a modified-live viral (MLV) and a high ...
L S, Goehring, B, Wagner, R, Bigbie, S B, Hussey, S, Rao, P S, Morley, D P, Lunn   +6 more
openaire   +2 more sources

Inoculation of mares and very young foals with EHV-1 glycoproteins D and B reduces virus shedding following respiratory challenge with EHV-1

Veterinary Immunology and Immunopathology, 2006
We have previously demonstrated that intramuscular inoculation of EHV-1 glycoprotein D (gD) and glycoprotein B (gB) produced by a recombinant baculovirus and formulated with the adjuvant Iscomatrix elicited virus-neutralizing antibody and gD- and gB-specific ELISA antibody in adult horses.
Foote, C.E., Raidal, S.L., Pecenpetelovska, G., Wellington, J.E., Whalley, J.M.   +4 more
openaire   +2 more sources

Control and disease clearance after neurological EHV‐1 in the UK

Veterinary Record, 2017
Camilla Strang and Richard Newton of the AHT’s Epidemiology and Disease Surveillance Group describe the management of a recent outbreak of equine herpesvirus type 1 neurological disease On 31 May 2017 the Animal Health Trust (AHT) was informed of a case of equine herpesvirus type 1 (EHV-1) neurological disease on a thoroughbred racing yard in northern
Camilla, Strang, Richard, Newton
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