Results 31 to 40 of about 2,007 (161)

Identification and genetic characterization of equine infectious anemia virus in Western Balkans

BMC Veterinary Research, 2021
Background Equine infectious anemia (EIA) is a viral disease, caused by the Equine Infectious Anemia virus (EIAV) belonging to the Retroviridae family, genus Lentivirus.
Diana Lupulovic, Sara Savić, Delphine Gaudaire, Nicolas Berthet, Živoslav Grgić, Kazimir Matović, Alexandre Deshiere, Aymeric Hans   +7 more
doaj   +1 more source

Progress and Perspectives in the Development of Lentiviral Vector Producer Cells

Biotechnology Journal, Volume 16, Issue 1, January 2021., 2021
Lentiviral vectors (LV) are widely used in gene therapy and genome editing. Their manufacturing is progressing towards the use of stable producer cell lines, inducible or constitutive. Both stable cell lines are genetically engineered to suppress LV cytotoxicity, either temporarily or permanently.
Mariana V. Ferreira, Elisa T. Cabral, Ana Sofia Coroadinha   +2 more
wiley   +1 more source

Serological Method Using Recombinant S2 Protein To Differentiate Equine Infectious Anemia Virus (EIAV)-Infected and EIAV-Vaccinated Horses [PDF]

Clinical and Vaccine Immunology, 2004
ABSTRACT We recently reported a highly protective attenuated live virus vaccine for equine infectious anemia virus (EIAV) based on a proviral construct (EIAV UK ΔS2) with a genetically engineered mutation in the viral S2 gene that eliminates expression of this accessory protein.
Sha, Jin, Charles J, Issel, Ronald C, Montelaro   +2 more
openaire   +2 more sources

An EIAV field isolate reveals much higher levels of subtype variability than currently reported for the equine lentivirus family

Retrovirology, 2009
Background Equine infectious anemia virus (EIAV), a lentivirus that infects horses, has been utilized as an animal model for the study of HIV. Furthermore, the disease associated with the equine lentivirus poses a significant challenge to veterinary ...
Zhang Baoshan, Barnes Shannon, Craigo Jodi K, Cook Sheila J, Howe Laryssa, Issel Charles J, Montelaro Ronald C   +6 more
doaj   +1 more source

Surveillance of the equine infectious anemia virus in Eastern and Central Saudi Arabia during 2014-2016 [PDF]

Veterinary World, 2019
Background: Equine infectious anemia virus (EIAV) is one of the most important threats to the equine industry globally. This is due to the poor performance of the affected horses, which requires euthanization of the infected animals upon the infection ...
Abdulmohsen Abdullah Alnaeem, Maged Gomaa Hemida   +1 more
doaj   +1 more source

EIAV-based retinal gene therapy in the shaker1 mouse model for usher syndrome type 1B: development of UshStat.

PLoS ONE, 2014
Usher syndrome type 1B is a combined deaf-blindness condition caused by mutations in the MYO7A gene. Loss of functional myosin VIIa in the retinal pigment epithelia (RPE) and/or photoreceptors leads to blindness.
Marisa Zallocchi, Katie Binley, Yatish Lad, Scott Ellis, Peter Widdowson, Sharifah Iqball, Vicky Scripps, Michelle Kelleher, Julie Loader, James Miskin, You-Wei Peng, Wei-Min Wang, Linda Cheung, Duane Delimont, Kyriacos A Mitrophanous, Dominic Cosgrove   +15 more
doaj   +1 more source

Antigenic analysis of equine infectious anemia virus (EIAV) variants by using monoclonal antibodies: epitopes of glycoprotein gp90 of EIAV stimulate neutralizing antibodies [PDF]

Journal of Virology, 1987
Monoclonal antibodies produced against the prototype cell-adapted Wyoming strain of equine infectious anemia virus (EIAV), a lentivirus, were studied for reactivity with the homologous prototype and 16 heterologous isolates. Eighteen hybridomas producing monoclonal antibodies (MAbs) were isolated.
K A, Hussain, C J, Issel, K L, Schnorr, P M, Rwambo, R C, Montelaro   +4 more
openaire   +2 more sources

A Pilot Study Comparing the Development of EIAV Env-Specific Antibodies Induced by DNA/Recombinant Vaccinia-Vectored Vaccines and an Attenuated Chinese EIAV Vaccine [PDF]

Viral Immunology, 2012
Data from successful attenuated lentiviral vaccine studies indicate that fully mature Env-specific antibodies characterized by high titer, high avidity, and the predominant recognition of conformational epitopes are associated with protective efficacy.
Qinglai, Meng, Yuezhi, Lin, Jian, Ma, Yan, Ma, Liping, Zhao, Shenwei, Li, Kai, Yang, Jianhua, Zhou, Rongxian, Shen, Xiaoyan, Zhang, Yiming, Shao   +10 more
openaire   +2 more sources

Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly. [PDF]

PLoS Pathogens, 2020
Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization, leading to an immature virus particle that is formed by a protein lattice based on dimeric ...
Robert A Dick, Chaoyi Xu, Dustin R Morado, Vladyslav Kravchuk, Clifton L Ricana, Terri D Lyddon, Arianna M Broad, J Ryan Feathers, Marc C Johnson, Volker M Vogt, Juan R Perilla, John A G Briggs, Florian K M Schur   +12 more
doaj   +1 more source

The efficacy of ELISA commercial kits for the screening of equine infectious anemia virus infection

Revista Argentina de Microbiología, 2015
The most used and reliable indicator of equine infectious anemia virus (EIAV) infection is the detection of its specific antibodies in horse serum. In the present study, the performance of two commercial ELISA tests for the detection of EIAV antibodies ...
Irene Alvarez, Fabiana Cipolini, Andrés Wigdorovitz, Karina Trono, Maria E Barrandeguy   +4 more
doaj   +1 more source