Results 121 to 130 of about 21,935 (239)

Regulatory roles of bioactive lipids in vascular homeostasis and remodeling

Medical Review
Bioactive lipids are low-abundance, rapidly acting signaling molecules that orchestrate vascular homeostasis and remodeling through a closed-loop cycle of synthesis, localization, receptor/effector sensing, and inactivation.
Yang Jie, Xiao Haiyan, Zhang Zhongze, Zhang Liuyang, Zhang Xu   +4 more
doaj   +1 more source

Deciphering Host Genomic Pathway Landscapes in Severe COVID‐19 by Exome Sequencing of a Large Admixed Brazilian Cohort

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The host genetic factors that resulted in the heterogeneous clinical outcomes of COVID‐19 remained poorly understood, especially in admixed populations that are underrepresented in global genomic studies. In this study, we investigated the genetic landscape associated with COVID‐19 severity using whole‐exome sequencing data from 325 Brazilian ...
Aléxia Stefani Siqueira Zetum, Danielle Ribeiro Campos da Silva, Vinícius do Prado Ventorim, Felipe Ataides Mion, Felipe dos Santos Passarela, Patrícia Brasil, Túlio de Lima Campos, Bartolomeu Acioli‐Santos, Flávio Rosendo da Silva Oliveira, Raquel Silva dos Reis Trabach, Lorena Souza Castro Altoé, Débora Dummer Meira, Iúri Drumond Louro   +12 more
wiley   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Effects of albumin on fatty acid, protein, and eicosanoid levels in rat mesenteric arterial bed perfusions

, 1988
Male rats were maintained on rat chow supplemented with 5% evening primrose oil for 2 weeks. Mesenteric perfusions were then performed, half with and half without albumin.
Janet C. Mitchell, D. Kenneth Jenkins, Mehar S. Manku, David F. Horrobin   +3 more
core   +1 more source

The effect of Greek mountain tea extract and wheat germ extract on peripheral blood flow and eicosanoid metabolism in mammals

Open Medicine
Polyphenols are a group of compounds identified as secondary metabolites of plants, with 8,000 types identified to date. Previous research findings have indicated the potential anti-inflammatory properties of polyphenols, with studies suggesting a ...
Pantano Licia, Hiroki Kento, Ono Ashiyu, Osada Yuta, Fujii Yasuyuki, Maiolino Luigi, Jacob Ursula M., Cammilleri Gaetano, Hippe Berit, Lo Dico Gianluigi M., Ferrantelli Vincenzo, Osakabe Naomi, Calabrese Vittorio   +12 more
doaj   +1 more source

Hypothetical model linking CFTR/DRM interaction with cytokine and eicosanoid release.

, 2013
TNF-α exerts two effects that seem to be dissociated: eicosanoid release and IL-8 synthesis with the participation of DRM, in which CFTR, cPLA2α, ANXA1, TNFR1 and c-Src are transiently recruited.
Grazyna Faure (41527), Diane-Lore Vieu (369683), Jesus Ayala-Sanmartin (24093), Mario Ollero (253565), Aleksander Edelman (171165), Janine Fritsch (369684), Marc Chanson (110081), Florence Borot (369682), Sandra Moriceau (369685), Julien Colas (369543), Maryvonne Baudouin-Legros (369686), Franck Brouillard (369687), Lhousseine Touqui (74585)   +12 more
core   +1 more source

Refractory ceramic fibers activate alveolar macrophage eicosanoid and cytokine release

, 1995
Refractory ceramic fiber has been developed for industrial processes requiring materials with high thermal and mechanical stability. To evaluate the biological activity of this fiber, rat alveolar macrophages were exposed for < or = 24 h to 0–1,000 ...
J. E. Lockey, G. D. Leikauf, S. P. Fink, M. L. Miller, K. E. Driscoll   +4 more
core   +1 more source

Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells

, 2014
512-519Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of ...
Das, Siddhartha, Ray, Suparna, Martinez, Leobarda Robles   +2 more
core  

Eicosanoid production by inflammatory cells recovered by flow cytometry.

, 2013
Eicosanoid production in cells recovered from tumor-bearing lungs by flow cytometry. Recovered cells were stimulated with ionophore A23187 (0.5 µM) for 12 minutes. Extracted eicosanoids were analyzed by LC/MS/MS.
Dwight Hanson (482165), Howard Li (194066), Jay Amin (194082), Robert C. Murphy (66787), Deandra Walker (482166), Xian Lu (482168), Raphael A. Nemenoff (194106), Mary Weiser-Evans (482167), Joanna M. Poczobutt (482163), Miguel Gijon (482164)   +9 more
core   +1 more source

Regulation of Immune Cells by Eicosanoid Receptors

, 2018
Eicosanoids are potent, bioactive, lipid mediators that regulate important components of the immune response, including defense against infection, ischemia, and injury, as well as instigating and perpetuating autoimmune and inflammatory conditions ...
Luster, Andrew, Kim, Nancy D.
core   +1 more source