Results 111 to 120 of about 21,372 (200)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking [PDF]

, 2010
Hematopoietic stem cell (HSC) transplantation is a potentially curative treatment for numerous hematologic malignancies. The transplant procedure as performed today takes advantage of HSC trafficking; either egress of HSC from the bone marrow to the ...
J Hoggatt, L M Pelus, Pelus, Louis M., Hoggatt, Jonathan   +3 more
core   +1 more source

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Developmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia‐related ...
Rachel K. Morgan, Evelyn K. Matei, Junru Pan, Tomoko Ishikawa, Katelyn M. Polemi, Ingrid Bergin, Sean P. Ferris, Hao Wang, Dana C. Dolinoy, Kelly M. Bakulski, Justin A. Colacino   +10 more
wiley   +1 more source

In Vitro Anti‐Inflammatory Activity of Sour Cherry (Prunus cerasus L.) Seed Oil and Computational Safety Profiling

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
In vitro anti‐inflammatory activity of sour cherry (Prunus cerasus L.) seed oil and computational safety profiling. ABSTRACT This study aimed to evaluate the in vitro anti‐inflammatory activity of sour cherry seed oils, including samples obtained by Soxhlet extraction and maceration, as well as ten commercial samples.
Tuğba Aydin, Tuğba Günbatan, Aysel Berkkan, Onur Kenan Ulutaş, Melike Sucu   +4 more
wiley   +1 more source

Fatty Acid Composition of Fixed Oil of Linum strictum and Its Antibiofilm, Anticoagulant, and α‐Amylase Inhibitory Effects–In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Chemical composition, in vitro biological activity and in silico molecular docking of fixed oil of Linum strictum. ABSTRACT The present study investigated the fatty acid composition of Linum strictum seed oil and evaluated its antibacterial, antibiofilm, anticoagulant, and α‐amylase inhibitory activities.
Hayet Edziri, Pooja Bargali, Marwa Melliti, Hasan Aljohi, Mohammad NasserAlkhrayef, Rim Gtari, Marcello Iriti, Ravendra Kumar, Ibrahim O. Alanazi   +8 more
wiley   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

The Roles of EETs in Neurological Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang, Mengya Li, Banglian Hu, Guoqiang Fei, Honghua Zheng, Xin Wang, Jing Ding   +6 more
wiley   +1 more source

Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapy

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan   +4 more
wiley   +1 more source

Regulatory roles of bioactive lipids in vascular homeostasis and remodeling

Medical Review
Bioactive lipids are low-abundance, rapidly acting signaling molecules that orchestrate vascular homeostasis and remodeling through a closed-loop cycle of synthesis, localization, receptor/effector sensing, and inactivation.
Yang Jie, Xiao Haiyan, Zhang Zhongze, Zhang Liuyang, Zhang Xu   +4 more
doaj   +1 more source

Eicosanoid Diversity of Stony Corals

, 2018
Oxylipins are well-established lipid mediators in plants and animals. In mammals, arachidonic acid (AA)-derived eicosanoids control inflammation, fever, blood coagulation, pain perception and labor, and, accordingly, are used as drugs, while ...
Helike Lõhelaid, Nigulas Samel
core   +1 more source