Results 101 to 110 of about 19,584 (228)

Polygonatum cyrtonema Polysaccharides‐Derived Metabolic Meta Alleviates ALD via a Gut–Liver Axis–Mediated, Bifidobacterium pseudolongum–Driven Suppression of the AA Metabolism–MAPK Signaling Network

Food Frontiers, Volume 7, Issue 4, July 2026.
This study demonstrates that the hepatoprotective effect of Polygonatum cyrtonema polysaccharide (PCP) is mediated by its gut microbiota‐derived metabolome, which enriches Bifidobacterium pseudolongum, suppresses the gut–liver axis of AA metabolism, and inhibits hepatic MAPK signaling. ABSTRACT Polygonatum cyrtonema, a traditional Chinese medicinal and
Xingcai Gao, Qing Zhou, Baoting Liu, Jun Li, Jianhua Xie, Yi Chen, Chenxu Gong, Xiaobo Hu, Qiang Yu   +8 more
wiley   +1 more source

Virus-Transformed Macrophage-Like Cell Line as Tool for Eicosanoid Research

, 1989
The ability of a virus-transformed murine macrophage like cell line HA 38 to produce different eicosanoid metabolites was examined. HA 38 cells release similar amounts of prostaglandins and leukotrienes as did murine peritoneal macrophages in response to
K Wessel, V Kaever, K Resch, W Ostertag, D Bitter-Suermann   +4 more
core   +1 more source

Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand[S]

Journal of Lipid Research, 2013
12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) has long been considered a by-product of thromboxane A2 (TxA2) biosynthesis with no biological activity.
Takehiko Matsunobu, Toshiaki Okuno, Chieko Yokoyama, Takehiko Yokomizo   +3 more
doaj   +1 more source

Ovulating Female of Nine‐Spined Sticklebacks (Pungitius sinensis) Are Attracted to Substances Derived From Male Kidneys

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 6, Page 545-553, July 2026.
ABSTRACT Male sticklebacks (Gasterosteidae) produce an adhesive protein called “spiggin” in the tubular epithelial cells of their kidneys, which they use to attach plants or plant debris together and build nesting sites. Spiggin is a glycoprotein excreted in urine.
Miki Nagaya, Hidenobu Yambe, Yasunori Koya   +2 more
wiley   +1 more source

Phospholipid Remodeling and Eicosanoid Signaling in Colon Cancer Cells

, 2014
512-519Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of ...
Das, Siddhartha, Ray, Suparna, Martinez, Leobarda Robles   +2 more
core  

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise‐induced cardiovascular and neuronal damage

British Journal of Pharmacology, Volume 183, Issue 13, Page 3762-3779, July 2026.
Abstract Background and Purpose Noise pollution, particularly by aircraft, is a significant risk factor for cardiovascular disease. Aircraft noise activates stress response pathways in the brain, via the amygdala, the sympathetic nervous system and the hypothalamic–pituitary–adrenal axis.
Ivana Kuntić, Marin Kuntić, Jiayin Zheng, Leonardo Nardi, Matthias Oelze, Arijan Valar, Dominika Mihaliková, Lea Strohm, Hans‐Georg Buchholz, Nicole Bausbacher, Simon Lange, Henning Ubbens, Qi Tang, Liyu Zhang, Guilherme Horta, Paul Stamm, Omar Hahad, Axel Methner, Sebastian Steven, Huige Li, Mathias Schreckenberger, Dilja Krueger‐Burg, Adrian Gericke, Michael J. Schmeisser, Thomas Münzel, Andreas Daiber   +25 more
wiley   +1 more source

EicosaCell – An Immunofluorescent-Based Assay to Localize Newly Synthesized Eicosanoid Lipid Mediators at Intracellular Sites

, 2016
Eicosanoids (prostaglandins, leukotrienes and lipoxins) are a family of signaling lipids derived from arachidonic acid that have important roles in physiological and pathological processes.
Bozza, Patricia T., Weller, Peter, Bandeira-Melo, Christianne   +2 more
core   +1 more source

Paired Hierarchical Organization of 13-Lipoxygenases in Arabidopsis

Plants, 2016
Embryophyte genomes typically encode multiple 13-lipoxygenases (13-LOXs) that initiate the synthesis of wound-inducible mediators called jasmonates. Little is known about how the activities of these different LOX genes are coordinated.
Adeline Chauvin, Aurore Lenglet, Jean-Luc Wolfender, Edward E. Farmer   +3 more
doaj   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, Volume 183, Issue 13, Page 3484-3502, July 2026.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets

Journal of Lipid Research, 2013
The dose-responsiveness of plasma oxylipins to incremental dietary intake of arachidonic acid (20:4n-6; ARA) and docosahexaenoic acid (22:6n-3; DHA) was determined in piglets. Piglets randomly received one of six formulas (n = 8 per group) from days 3 to
Maaike J. Bruins, Adrie D. Dane, Katrin Strassburg, Rob J. Vreeken, John W. Newman, Norman Salem, Jr., Cynthia Tyburczy, J.Thomas Brenna   +7 more
doaj   +1 more source