Results 81 to 90 of about 21,935 (239)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng +3 more
wiley +1 more source
, 2017 Absolute and 24-week changes in urinary eicosanoid levels by study arm (median with interquartile range).
Catherine N. Le (3694636) +4 more
core +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract The rhizosphere microbiome is critical for forest ecological functions, yet the mechanisms through which tree species identity and neighbour tree interactions are associated with its assembly remain poorly understood.
Yuemei Zhang +12 more
wiley +1 more source
Effect on eicosanoid concentrations.
, 2013 Effect of pre/co incubation with 5 mM erythritol (ERT) on HUVECS cultured in normal glucose (NG, 7 mM) or high glucose (HG, 30 mM) for 24 hours on eicosanoid concentrations in cell pellets (A) and culture medium (B).
Alvin Berger (418455) +6 more
core +1 more source
Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss
Integrative Zoology, EarlyView.The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng +7 more
wiley +1 more source
Identifying Intracellular Sites of Eicosanoid Lipid Mediator Synthesis with EicosaCell Assays
, 2016 Eicosanoids, arachidonic acid-derived signaling lipid mediators, are newly formed and nonstorable molecules that have important roles in physiological and pathological processes.
Bozza, Patricia T. +2 more
core +1 more source
Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
Frontiers in Cell and Developmental Biology, 2016 Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF and anti-EGFR targeting drugs, but these are limited by ...
Lorraine Burke +7 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan +5 more
wiley +1 more source
Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper
Allergy, EarlyView.ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres +19 more
wiley +1 more source
The fight of innate immunity and abnormal cannabinoids against Candida infection
British Journal of Pharmacology, EarlyView.Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori +2 more
wiley +1 more source