Results 71 to 80 of about 21,935 (239)

Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression [PDF]

, 2020
Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced apoptosis may trigger escape from dormancy of microtumors by interfering with inflammation ...
Hammock, Bruce D, Fishbein, Anna, Wang, Weicang, Yang, Jun, Panigrahy, Dipak, Hwang, Sung Hee, Deng, Jianjun, Huang, Sui, Gartung, Allison, Yang, Haixia, Verheul, Sanne ML, Verheul, Sanne M L, Hallisey, Victoria M, Bielenberg, Diane R, Wang, Yuxin, Kieran, Mark W   +15 more
core   +1 more source

Paired Hierarchical Organization of 13-Lipoxygenases in Arabidopsis

Plants, 2016
Embryophyte genomes typically encode multiple 13-lipoxygenases (13-LOXs) that initiate the synthesis of wound-inducible mediators called jasmonates. Little is known about how the activities of these different LOX genes are coordinated.
Adeline Chauvin, Aurore Lenglet, Jean-Luc Wolfender, Edward E. Farmer   +3 more
doaj   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets

Journal of Lipid Research, 2013
The dose-responsiveness of plasma oxylipins to incremental dietary intake of arachidonic acid (20:4n-6; ARA) and docosahexaenoic acid (22:6n-3; DHA) was determined in piglets. Piglets randomly received one of six formulas (n = 8 per group) from days 3 to
Maaike J. Bruins, Adrie D. Dane, Katrin Strassburg, Rob J. Vreeken, John W. Newman, Norman Salem, Jr., Cynthia Tyburczy, J.Thomas Brenna   +7 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source

Kinetic equations and their parameters of the arachidonic acid/eicosanoid metabolism model.

, 2014
Kinetic equations and their parameters of the arachidonic acid/eicosanoid metabolism model.
Vikash Pandey (188392), Julia Starmann (303348), Michael Trauner (124235), Holger Sültmann (214717), Helmut Denk (649546), Kurt Zatloukal (234954), Vyacheslav Amstislavskiy (649544), Christoph Wierling (188401), Meryem Ralser (649543), Hendrik Hache (419872), Karl Kashofer (429432), Ingrid Osprian (649545), Marc Sultan (33002), Hans Lehrach (4881), Marie-Laure Yaspo (19028), Christina Grimm (280266)   +15 more
core   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Eicosanoid profiles of cPLA₂α WT and KO FTOC supernatants and adult mouse thymuses.

, 2015
A. Expression distribution of the eicosanoids present in cPLA2α WT FTOCs. The supernatants of FTOCs were collected at the indicated time of culture and the eicosanoid profiles were determined by combined liquid chromatography/tandem mass spectrometry ...
Gajendra S. Naika (738149), Michael H. Gelb (257901), Jean Perron (683631), Frederic Jacques (683630), Matthieu Rousseau (683626), Eric Boilard (683632)   +5 more
core   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Polyunsaturated fatty acids alter the formation of lipid droplets and eicosanoid production in Leishmania promastigotes

, 2023
BACKGROUND The knowledge about eicosanoid metabolism and lipid droplet (LD) formation in the Leishmania is very limited and new approaches are needed to identify which bioactive molecules are produced of them.
Monara Viera de Castro (14728748), Lúcia Helena Faccioli (7475723), Carlos Arterio Sorgi (5652064), Victor de Souza Tavares (12682369), Théo Araújo-Santos (360105), Jonilson Berlink Lima (6892640), Valéria M Borges (4680088), Yasmin Monara Ferreira de Sousa Andrade (14728745), Rayane da Silva Oliveira Souza (14487811)   +8 more
core   +1 more source