Results 151 to 160 of about 68,592 (324)

Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids

Cell, 2020
Nikos Koundouros, Evdoxia Karali, Aurelien Tripp, A. Valle, P. Inglese, N. Perry, David J. Magee, Sara Anjomani Virmouni, George A. Elder, A. Tyson, M. L. Doria, Antoinette van Weverwijk, Renata F. Soares, C. Isacke, J. Nicholson, R. Glen, Z. Takáts, G. Poulogiannis   +17 more
semanticscholar   +1 more source

Incidence Rate of Otitis Externa Episodes in Atopic Dogs Is Reduced by a Therapeutic Diet in a 6‐Month Randomised, Blinded, Controlled, Clinical Trial

Veterinary Dermatology, Volume 37, Issue 1, Page 89-102, February 2026.
ABSTRACT Background Recurrent otitis externa (OE) episodes commonly affect dogs with canine atopic dermatitis (cAD) despite ongoing cAD treatment. Objective To determine if a therapeutic diet with active ingredients targeting the skin barrier and allergy pathways reduces the incidence rate of OE.
Adrian Watson, Jeremy Laxalde, Franco Martini, Nina Fischer, Elisa Maina, Claude Favrot   +5 more
wiley   +1 more source

Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements [PDF]

, 2001
Olaf Dransfeld, Irini Rakatzi, Shlomo Sasson, Arie Gruzman, Marcus Schmitt, Dieter Häussinger, Jürgen Eckel   +6 more
openalex   +1 more source

Effects of non‐steroidal anti‐inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses: EAACI task force on eicosanoids consensus report in times of COVID‐19 [PDF]

, 2022
Milena Sokołowska, G. Enrico Rovati, Zuzana Diamant, Eva Untersmayr, Jürgen Schwarze, Zuzanna Łukasik, Florentina Sava, Alba Angelina, Óscar Palomares, Cezmi A. Akdiş, Liam O’Mahony, Miloš Jeseňák, Oliver Pfaar, Marı́a José Torres, Marek Sanak, Sven‐Erik Dahlén, Grzegorz Woszczek   +16 more
openalex   +1 more source

Metabolome Atlas of Brain Reveals Regional Shared and Unique Metabolic Drifts in Response to Type 2 Diabetes in Male Mice

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
A detailed metabolome atlas of the male mouse brain was established, incorporating metabolomic and lipidomic profiling of seven anatomical regions. T2D induced marked metabolic alterations, which were mainly associated with lipotoxicity, defective energy metabolism, proinflammatory processes, and neurotoxicity.
Yang Zhou, Yitong Lu, Zhaobao Wang, Xiaoqian Du, Bei Jiang, Qiuhui Xuan   +5 more
wiley   +1 more source

The calcineurin–NFATc pathway modulates the lipid mediators in BAL fluid extracellular vesicles, thereby regulating microvascular endothelial cell barrier function

Frontiers in Physiology
Extracellular vesicles mediate intercellular communication by transporting biologically active macromolecules. Our prior studies have demonstrated that the nuclear factor of activated T cell cytoplasmic member 3 (NFATc3) is activated in mouse pulmonary ...
Manjula Karpurapu, Yunjuan Nie, Sangwoon Chung, Jiasheng Yan, Patrick Dougherty, Sonal Pannu, Jon Wisler, Ryan Harkless, Narasimham Parinandi, Evgeny Berdyshev, Dehua Pei, John W. Christman   +11 more
doaj   +1 more source

Phospholipase A₂regulates eicosanoid class switching during inflammasome activation [PDF]

, 2014
Paul C. Norris, David Gosselin, Donna Reichart, Christopher K. Glass, Edward A. Dennis   +4 more
openalex   +1 more source

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP‐43 Mouse Model of Frontotemporal Dementia

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Hayatte‐Dounia Mir, Giada Giorgini, Irene Santos‐García, Elizabeth Dumais, Carmen Rodríguez‐Cueto, Eva de Lago, Cristoforo Silvestri, Nicolas Flamand, Javier Fernández‐Ruiz, Vincenzo Di Marzo   +9 more
wiley   +1 more source

Effects on plasma endotoxin and eicosanoid concentrations and serum cytokine activities in horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions [PDF]

, 2003
Michelle Henry Barton, Lisa H. Williamson, Stephanie Jacks, Natalie Norton   +3 more
openalex   +1 more source

12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source