Results 131 to 140 of about 48,800 (245)

Role of phospholipase A2 in the stimulation of sponge cell proliferation by homologous lectin. [PDF]

, 1989
Friese, K., Fritsche, U., Gramzow, M., Kreuter, M., Kurelec, B., Müller, W., Robitzki, A., Schröder, H., Zimmermann, H.   +8 more
core   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou, Alex Vo, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Steven Good, Arantxa Horga, Nancy Agrawal, Janet Hammond   +10 more
wiley   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, Volume 183, Issue 9, Page 2049-2060, May 2026.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, Volume 58, Issue 3, Page 845-856, May 2026.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Pharmacokinetics and Anti‐Inflammatory Effects of Intramuscular Betamethasone in Exercised Thoroughbred Horses

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 295-305, May 2026.
ABSTRACT The pharmacokinetics and pharmacodynamics of betamethasone following intra‐articular administration to horses have been described; however, studies characterizing intramuscular administration are lacking. Twenty‐four horses received an intramuscular dose of 12 mg betamethasone sodium phosphate/betamethasone acetate.
Juliana Sullivan, Jeff Blea, Daniel S. McKemie, Philip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

Liver‐Specific Suppression of PLA2G6/iPLA2β Improves Glucose and Lipid Metabolism in High‐Fat Diet‐Fed Mice

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Liver‐specific suppression of PLA2G6/iPLA2β by utilizing the short‐hairpin RNA knockdown technique using an adenovirus vector (Ad‐shPLA2G6) altered phospholipid and fatty acid metabolites and suppressed hepatic lipid accumulation, serum triglyceride, and fasting glucose levels.
Kahori Shimizu, Mana Nishibata, Katsuyuki Nagata, Sho Hori, Shotaro Michinaga, Miyuki Kanehara, Miho Hashimoto‐Iwasaki, Fuminori Sakurai, Hideo Shindou, Koji Tomita, Toru Nishinaka, Hiroyuki Mizuguchi   +11 more
wiley   +1 more source

Design, Synthesis, and Evaluation of New Polyhydroxylated Bis‐Chalcones as Potential COX‐2 Selective Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Novel polyhydroxylated bis‐chalcones were successfully synthesized and demonstrated COX‐2 selective inhibition. The most potent and selective inhibitor exhibited a mixed‐type inhibition mechanism with COX‐2. Its additional bulk preferentially blocked the access to the active pocket of COX‐1 rather than COX‐2. Selective inhibition of COX‐2 is considered
Rui Pereira, Alberto N. Araújo, Daniela Ribeiro, Ismael Rufino, Nuno Martinho, Rita C. Guedes, Vera L. M. Silva, Eduarda Fernandes   +7 more
wiley   +1 more source

Tumor Lipidomic Changes after Treatment with Polymeric Hydroxychloroquine in a Syngeneic Murine Model of Pancreatic Cancer. [PDF]

ACS Omega
Kollala SS, Ding L, Panja S, Singh AB, Oupicky D, Murry DJ.   +5 more
europepmc   +1 more source

Assessment of lipid mediators in the urine of patients with Lyme disease, tick-borne encephalitis and human granulocytic anaplasmosis. [PDF]

Sci Rep
Biernacki M, Skrzydlewska E, Dobrzyńska M, Czupryna P, Adamczuk J, Moniuszko-Malinowska A.   +5 more
europepmc   +1 more source