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Efficient <i>in vitro</i> assay for evaluating drug efficacy and synergy against emerging SARS-CoV-2 strains. [PDF]

open access: yesAntimicrob Agents Chemother
Woodall M   +13 more
europepmc   +1 more source

Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative. [PDF]

open access: yesActa Pharm Sin B
Chen Y   +10 more
europepmc   +1 more source

3-Deazaguanosine inhibits SARS-CoV-2 viral replication and reduces the risk of COVID-19 pneumonia in hamster. [PDF]

open access: yesiScience
Saito-Tarashima N   +11 more
europepmc   +1 more source

Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase. [PDF]

open access: yesNAR Mol Med
Sloan A   +11 more
europepmc   +1 more source
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A clean industrial scheme for de-ketalization of EIDD-2801 intermediate in water to give molnupiravir (MK-4482) anti-COVID-19 agent (containing its pharmaceutical analytical analysis)

Scientiae Radices, 2023
Due to the need for molnupiravir (EIDD-2801, MK-4482) anti-COVID-19 agent, in the present report, we have systematically investigated the effect of different solvents, acids (as catalyst), temperature, and other parameters which play rolls in De-ketalization process of its key intermediate. At the first glance, it might seem to be easy, but the complex
Seyyed Amir Siadati   +6 more
openaire   +1 more source

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