Results 81 to 90 of about 809 (101)

Safety of RNA-Dependent RNA Polymerase Inhibitors, Molnupiravir and VV116, for Oral Treatment of COVID-19: A Meta-Analysis. [PDF]

Iran J Med Sci
Zheng Z, Zhou J, Song Y.
europepmc   +1 more source

Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative. [PDF]

Acta Pharm Sin B
Chen Y, Liu Y, Li G, Peng C, Liang D, Yang S, Zheng P, Li S, Guo D, Zhou Q, Zhang X.   +10 more
europepmc   +1 more source

From Challenge to Cure: A Look at Feline Infectious Peritonitis and Emerging Treatment Strategies and Breakthroughs. [PDF]

Vet Sci
Mir S, Peters M, Penny G, Agsaoa A, Mir M.   +4 more
europepmc   +1 more source

3-Deazaguanosine inhibits SARS-CoV-2 viral replication and reduces the risk of COVID-19 pneumonia in hamster. [PDF]

iScience
Saito-Tarashima N, Koma T, Hinotani N, Yoshida K, Ogasa M, Murai A, Inoue S, Kondo T, Doi N, Tsuneyama K, Nomaguchi M, Minakawa N.   +11 more
europepmc   +1 more source

Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase. [PDF]

NAR Mol Med
Sloan A, Gordon CJ, Prévost J, Audet J, Fulton K, Woolner E, Chang MH, Walker SM, Tchesnokov EP, Das K, Safronetz D, Götte M.   +11 more
europepmc   +1 more source

A concise route to MK-4482 (EIDD-2801) from cytidine

Chemical Communications, 2020
A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine.
Till Opatz, Grace Ahlqvist, Timothy F Jamison   +2 more
exaly   +6 more sources

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A clean industrial scheme for de-ketalization of EIDD-2801 intermediate in water to give molnupiravir (MK-4482) anti-COVID-19 agent (containing its pharmaceutical analytical analysis)

Scientiae Radices, 2023
Due to the need for molnupiravir (EIDD-2801, MK-4482) anti-COVID-19 agent, in the present report, we have systematically investigated the effect of different solvents, acids (as catalyst), temperature, and other parameters which play rolls in De-ketalization process of its key intermediate. At the first glance, it might seem to be easy, but the complex
Seyyed Amir Siadati, Marjan Samadi, Mehdi Soheilizad, Loghman Firoozpour, Meghdad Payab, Saeid Bagherpour, Bahareh Dindari   +6 more
openaire   +1 more source

Exploring molnupiravir (EIDD-2801) by molecular docking, temperature-dependent dynamics simulations, and DFT calculations on the RNA-dependent RNA polymerase (RdRp) from SARS-CoV-2

Proceedings of 7th International Electronic Conference on Medicinal Chemistry, 2021
Edeildo Silva-Júnior, Leandro Silva
exaly   +3 more sources

DFT study of Anti Sars-Cov-2 EIDD-1931 and EIDD-2801 molecular structures

Anais do VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular, 2020
Scientists around the world are joining efforts in the study of the current SARS-CoV-2 virus and the Covid-19 disease. As a result, several compounds have been studied for the treatment of SARS-CoV-2, among them there are N4-hydroxycytidine prodrug (NHC; EIDD-1931), and EIDD-2801, that have shown antiviral activity against SARS-CoV-2.
Antonio L. de Almeida, João B. L. Martins   +1 more
exaly   +2 more sources