Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. [PDF]
Molecular and Cellular Biology, 1986 Selective translation of influenza viral mRNAs occurs after influenza virus superinfection of cells infected with the VAI RNA-negative adenovirus mutant dl331 (M. G. Katze, Y.-T. Chen, and R. M. Krug, Cell 37:483-490, 1984).
Michael G. Katze +3 more
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Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. [PDF]
Proceedings of the National Academy of Sciences, 1991 We have cloned the cDNA of the heme-regulated eIF-2 alpha kinase (HRI) of rabbit reticulocytes. In vitro translation of mRNA transcribed from the HRI cDNA yields a 90-kDa polypeptide that exhibits eIF-2 alpha kinase activity and is recognized by a ...
J J Chen +6 more
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Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2 [PDF]
Journal of Biological Chemistry, 1996 In yeast, starvation for amino acids stimulates GCN2 phosphorylation of the α subunit of eukaryotic initiation factor-2 (eIF-2). Phosphorylation of eIF-2α induces the translational expression of GCN4, a transcriptional activator of the general amino acid
Shuhao Zhu +2 more
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Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI. [PDF]
Molecular and Cellular Biology, 1989 The double-stranded RNA (dsRNA)-dependent protein kinase DAI (also termed dsI and P1) possesses two kinase activities; one is an autophosphorylation activity, and the other phosphorylates initiation factor eIF-2. We purified the enzyme, in a latent form, to near homogeneity from interferon-treated human 293 cells.
Matthew J. Kostura, Michael B. Mathews
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Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells. [PDF]
Proceedings of the National Academy of Sciences, 1992 The expression of a molecular cDNA clone (P1 KIN) of the human RNA-dependent P1/eIF-2 alpha protein kinase (PKR) was examined in transfected monkey cells and in cell-free protein-synthesizing systems.
Daniel C. Thomis, Charles E. Samuel
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Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae. [PDF]
Molecular and Cellular Biology, 1994 Previous studies have demonstrated that the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha), encoded by the SUI2 gene in the yeast Saccharomyces cerevisiae, is phosphorylated at Ser-51 by the GCN2 kinase in response to general amino acid control.
Lan Feng, Haejin Yoon, Thomas F. Donahue
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Proceedings of the National Academy of Sciences of the United States of America, 1995 The protein encoded by the gamma 134.5 gene of herpes simplex virus precludes premature shutoff of protein synthesis in human cells triggered by stress associated with onset of viral DNA synthesis.
J Chou +3 more
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Proceedings of the National Academy of Sciences of the United States of America, 1979 The phosphorylation of purified protein synthesis factors catalyzed by protein kinase preparations isolated from interferon-treated human amnion cells was examined.
Charles E. Samuel
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Proceedings of the National Academy of Sciences of the United States of America, 1979 Heme deficiency in rabbit reticulocytes and their lysates leads to the activation of a heme-regulated translational inhibitor (HRI) which causes the cessation of polypeptide initiation.
Rajinder Singh Ranu, Irving M. London
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GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells. [PDF]
EMBO Journal, 1995 Carlos R. Vázquez de Aldana +2 more
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