Zhongguo shipin weisheng zazhi, 2023 ObjectiveTo study the cardioprotective effect of sesame ethanol extract （SEE） on exercise-induced fatigue （EIF） rats and its effects on myocardial physiological and biochemical parameters.MethodsRats were randomly divided into control group （Control ...
LI Qiang, MAO Yufeng
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Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. [PDF]
Molecular and Cellular Biology, 1988 The phosphorylation of the alpha-subunit of initiation factor eIF-2 leads to an inhibition of protein synthesis in mammalian cells. We have performed site-directed mutagenesis on a cDNA encoding the alpha-subunit of human eIF-2 and have replaced the candidate sites of phosphorylation, Ser-48 and Ser-51, with alanines.
V K, Pathak, D, Schindler, J W, Hershey
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The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition [PDF]
Diabetes & Metabolism Journal, 2011 Backgroundβ-cell death due to endoplasmic reticulum (ER) stress has been regarded as an important pathogenic component of type 2 diabetes. The possibility has been suggested that sulfonylurea, currently being used as one of the main oral hypoglycemic ...
Min Jeong Kwon +10 more
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Curcumin: a bioactive compound with molecular targets for human malignancies
Food and Agricultural Immunology, 2023 Cancer is the second leading cause of death in the world and one of the major public health problems. Curcumin has anticancer activity including inducing apoptosis and inhibiting proliferation and invasion of tumours by suppressing a variety of cellular ...
Muhammad Shahbaz +12 more
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Sensory Denervation Modulates eIF-2 Alpha Kinase Expression in the Rabbit Lacrimal Gland [PDF]
Current Eye Research, 2006 To investigate the hypothesis that sensory denervation of the rabbit lacrimal gland results in dysregulation of protein synthesis. We used differential display of mRNA to identify genes associated with protein synthesis and secretion that may be altered in this situation.New Zealand white rabbits underwent unilateral sensory denervation by the ablation
Doan H, Nguyen +3 more
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Purification and Activation of the Double-Stranded RNA-Dependent eIF-2 Kinase DAI [PDF]
Molecular and Cellular Biology, 1989 The double-stranded RNA (dsRNA)-dependent protein kinase DAI (also termed dsI and P1) possesses two kinase activities; one is an autophosphorylation activity, and the other phosphorylates initiation factor eIF-2. We purified the enzyme, in a latent form, to near homogeneity from interferon-treated human 293 cells.
M, Kostura, M B, Mathews
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Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells. [PDF]
PLoS ONE, 2015 Gefitinib and erlotinib are anticancer agents, which inhibit epidermal growth factor receptor (EGFR) tyrosine kinase. Interstitial lung disease (ILD) occurs in patients with non-small cell lung cancer receiving EGFR inhibitors.
Satoshi Koyama +7 more
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Regulation of the interactions between human eIF5 and eIF1A by the CK2 kinase
Current Research in Structural Biology, 2022 Translation initiation in eukaryotes relies on a complex network of interactions that are continuously reorganized throughout the process. As more information becomes available about the structure of the ribosomal preinitiation complex (PIC) at various ...
Nathan Gamble +3 more
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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. [PDF]
PLoS ONE, 2007 TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two functionally and structurally distinct multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2).
Kathrin Thedieck +7 more
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Characterization and QTL Mapping of a Major Field Resistance Locus for Bacterial Blight in Rice
Plants, 2022 Bacterial blight (BB) disease, caused by Xanthomonas oryzae pv. oryzae (Xoo), is among the major factors that can cause rice yields to decrease. To address BB disease, researchers have been looking for ways to change pesticides and cultivation methods ...
Jae-Ryoung Park +6 more
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