Results 1 to 10 of about 23,988 (146)

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease [PDF]

Frontiers in Molecular Neuroscience, 2014
Cell signaling in response to an array of diverse stress stimuli converges on the phosphorylation of eukaryotic initiation factor-2α (eIF2α). Evidence is accumulating that persistent eIF2α phosphorylation at Ser51 through prolonged overactivation of ...
Masuo eOhno, Masuo eOhno
doaj   +3 more sources

Endoplasmic Reticulum Stress Mediated MDRV p10.8 Protein-Induced Cell Cycle Arrest and Apoptosis Through the PERK/eIF2α Pathway [PDF]

Frontiers in Microbiology, 2018
In this study, the mechanism of Muscovy duck reovirus (MDRV) p10.8 protein-induced pathogenesis was investigated, with a focus on endoplasmic reticulum (ER) stress.
Quanxi Wang, Quanxi Wang, Xiaoqin Yuan, Xiaoqin Yuan, Yuan Chen, Yuan Chen, Qingli Zheng, Qingli Zheng, Lihui Xu, Yijian Wu   +9 more
doaj   +2 more sources

Hypothalamic eIF2α Signaling Regulates Food Intake [PDF]

Cell Reports, 2014
The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation.
Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, Valérie Carraro, Christophe Guissard, Julien Averous, Céline Jousse, Alain Bruhat, Cédric Chaveroux, Wafa B’chir, Yuki Muranishi, David Ron, Luc Pénicaud, Pierre Fafournoux   +15 more
doaj   +2 more sources

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells [PDF]

OncoImmunology, 2018
The immunogenic cell death (ICD) process represents a novel therapeutic approach to treat tumours, in which cytotoxic compounds promote both cancer cell death and the emission of damage-associated molecular patterns (DAMPs) from dying cells, to activate ...
Paola Giglio, Mara Gagliardi, Nicola Tumino, Fernanda Antunes, Soraya Smaili, Diego Cotella, Claudio Santoro, Roberta Bernardini, Maurizio Mattei, Mauro Piacentini, Marco Corazzari   +10 more
doaj   +2 more sources

Regulation of G1 Arrest and Apoptosis in Hypoxia by PERK and GCN2-Mediated eIF2α Phosphorylation

Neoplasia: An International Journal for Oncology Research, 2010
Hypoxia is a common microenvironment in solid tumors and is correlated with tumor progression by regulating cancer cell survival. Recent studies suggest that activation of double-stranded RNA-dependent protein kinase-like endoplasmic reticulum-related ...
Yan Liu, Csaba László, Yi Liu, Wei Liu, Xiaozhuo Chen, Susan C. Evans, Shiyong Wu   +6 more
doaj   +2 more sources

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2014
β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) initiates the production of β-amyloid (Aβ), the major constituent of amyloid plaques in Alzheimer's disease (AD).
Katherine R Sadleir, William A Eimer, Randal J Kaufman, Pavel Osten, Robert Vassar   +4 more
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تأثیر شش هفته تمرین هوازی بر بیان ژن‌های استرس اکسیداتیو شبکه آندوپلاسمی (X-box Binding Protein-1 و Eukaryotic Initiation Factor-2α) در بافت قلب موش‌های صحرایی نر دیابتی شده با استرپتوزوتوسین [PDF]

مجله دانشکده پزشکی اصفهان, 2022
مقدمه: هدف از انجام پژوهش حاضر، بررسی تأثیر شش هفته تمرین هوازی بر بیان ژن‌های استرس اکسیداتیو شبکه‌ی آندوپلاسمی (Endoplasmic reticulum یا ER) شامل عامل شروع‌کننده‌ی ترجمه‌ی یوکاریوتی 2 (Eukaryotic Initiation Factor-2α یا eIF2α) و پروتئین ...
معصومه حسین‌زاده, اسماء طاهری   +1 more
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Modulation of GCN2 activity under excess light stress by osmoprotectants and amino acids

Plant Signaling & Behavior, 2022
The protein kinase GCN2 (General Control Nonderepressible2) and its phosphorylation target, the eukaryotic translation initiation factor (eIF)2α represent the core module of the plant’s integrated stress response, a signaling pathway widely conserved in ...
Ansul Lokdarshi, Albrecht G von Arnim, Teressa K Akuoko   +2 more
doaj   +1 more source

GCN2 upregulates autophagy in response to short-term deprivation of a single essential amino acid

Autophagy Reports, 2022
The ability to adapt the proteolysis rates based on fluctuations in essential amino acid (EAA) availability is essential for life. The GCN2-eIF2α-ATF4 signaling pathway is involved in the adaptive response to EAA deprivations.
Anne-Catherine Maurin, Laurent Parry, Wafa B’chir, Valérie Carraro, Cécile Coudy-Gandilhon, Ghita Chaouki, Cédric Chaveroux, Sylvie Mordier, Brigitte Martinie, Vanessa Reinhardt, Céline Jousse, Alain Bruhat, Patrice Codogno, Julien Averous, Pierre Fafournoux   +14 more
doaj   +1 more source

Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α [PDF]

Journal of Biological Chemistry, 2004
In pancreatic beta-cells, glucose causes a rapid increase in the rate of protein synthesis. However, the mechanism by which this occurs is poorly understood. In this report, we demonstrate, in the pancreatic beta-cell line MIN6, that glucose stimulates the recruitment of ribosomes onto the mRNA, indicative of an increase in the rate of the initiation ...
E. Gomez, M.L. Powell, I.C. Greenman, Terence Herbert   +3 more
openaire   +3 more sources