Results 131 to 140 of about 35,642 (231)
iMetaOmics, Volume 3, Issue 1, March 2026.Schematic of the study design. In this study, we developed a comprehensive unfolded protein response (UPR) gene signature and applied it to systematically characterize the UPR landscape across multiple cancer types. By integrating bulk and single‐cell transcriptomic data, we revealed substantial inter‐ and intra‐tumoral heterogeneity in UPR activity ...
Xinyu Yang +8 more
wiley +1 more source
iNew Medicine, Volume 2, Issue 1, March 2026.ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi +14 more
wiley +1 more source
E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. [PDF]
, 2019 Objective: Since the introduction in 2004, global usage of e-cigarettes (ECs) has risen exponentially. However, the risks of ECs on oral health are uncertain.
Chen, Wei +9 more
core
Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence
Journal of Clinical Laboratory Analysis, Volume 40, Issue 5, March 2026.Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu +5 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.ABSTRACT Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocyte‐endothelial communication in glomerular disease.
Zhao Liu +10 more
wiley +1 more source
Combination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress [PDF]
, 2023 Chunhua She +13 more
openalex +1 more source
MedComm, Volume 7, Issue 3, March 2026.This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng +8 more
wiley +1 more source
Rapamycin-induced Translational Derepression of GCN4 mRNA Involves a Novel Mechanism for Activation of the eIF2α Kinase GCN2 [PDF]
, 2003 Hiroyuki Kubota +4 more
openalex +1 more source
HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2 [PDF]
, 2010 Philippos Peidis +3 more
openalex +1 more source
The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance
MedComm – Oncology, Volume 5, Issue 1, March 2026.One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang +3 more
wiley +1 more source