Results 211 to 220 of about 62,911 (266)
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Elastase activity: The role of elastase in aortic aneurysm formation
Journal of Surgical Research, 1982Abstract Elastase activity was studied in aortic tissue obtained from patients with aortic aneurysm and arteriosclerotic occlusive disease. Aneurysmal tissue demonstrates significantly greater activity than the arteriosclerotic aorta and the activity is localized to the intima and inner media.
R W, Busuttil +3 more
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The role of tyrosines in elastase
Archives of Biochemistry and Biophysics, 1972Abstract The conformational behavior of elastase between pH 7 and 11 has been investigated, with particular emphasis on tyrosine residues. Of these, ten titrate normally and one is totally inaccessible to ionization. On the basis of chemical modification, the eleven tyrosines can be subdivided into three reactive classes and one totally unreactive ...
M J, Gorbunoff, S N, Timasheff
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On the specificity of porcine elastase
Biochimica et Biophysica Acta (BBA) - Enzymology, 1975The specificity of porcine elastase (EC 3.4.4.7) has been studied. Ethyl esters derived from benzoyl amino acids with straight side chains are better substrates than those with branched side chains; the best substrate is norvaline ester. In the series of benzoylalanine alkyl esters the alcohol moiety markedly affects the susceptibility.
R, Gold, Y, Shaltin
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Neutrophil elastase and cancer
Surgical Oncology, 2006This mini-review summarizes our recent experimental and clinical studies on neutrophil elastase (NE) and cancer based on our original view point. Neoplasms metastasize as a result of a complex series of events. This process requires various degradative enzymes including proteases.
Takashi, Sato +7 more
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The Journal of Immunology, 1959
Summary Although crystalline elastase has a molecular weight of only 25,000, an antibody was obtained in rabbits injected with an elastase-adjuvant mixture. The antibody produced a precipitin reaction in vitro as well as passive anaphylaxis in guinea pigs.
B C, McIVOR, H D, MOON
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Summary Although crystalline elastase has a molecular weight of only 25,000, an antibody was obtained in rabbits injected with an elastase-adjuvant mixture. The antibody produced a precipitin reaction in vitro as well as passive anaphylaxis in guinea pigs.
B C, McIVOR, H D, MOON
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Synthetic Inhibitors of Elastase
Medicinal Research Reviews, 1994For more than two decades investigators around the world, in both academic and industrial institutions, have been developing inhibitors of human neutrophil elastase. A number of very elegant and insightful strategies have been reported. In the case of reversible peptidic inhibitors, this has resulted in the identification of some extremely potent ...
P D, Edwards, P R, Bernstein
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Nihon rinsho. Japanese journal of clinical medicine, 1995
Elastases are unique among the proteases in that they are capable of hydrolyzing the scleroprotein elastin. The enzymes include pancreatic elastases 1 (Protease E) and 2, and neutrophil elastase. These three elastases also have esterase and amidase activity toward synthetic substrates such as succinyl-trialanine-p-nitroanilide.
T, Hayakawa +3 more
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Elastases are unique among the proteases in that they are capable of hydrolyzing the scleroprotein elastin. The enzymes include pancreatic elastases 1 (Protease E) and 2, and neutrophil elastase. These three elastases also have esterase and amidase activity toward synthetic substrates such as succinyl-trialanine-p-nitroanilide.
T, Hayakawa +3 more
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Nature, 1960
SINCE Balo and Banga1 described the pancreatic enzyme elastase, its dissolving effect on elastin, and its possible implications in atherosclerosis, a considerable amount of interest has been focused on the quantitative measurement of its enzymatic activity.
A J, SBARRA +2 more
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SINCE Balo and Banga1 described the pancreatic enzyme elastase, its dissolving effect on elastin, and its possible implications in atherosclerosis, a considerable amount of interest has been focused on the quantitative measurement of its enzymatic activity.
A J, SBARRA +2 more
openaire +2 more sources