Results 221 to 230 of about 115,118 (303)

Dynamic Changes of Neutrophil Nuclear Membrane CD63 as a Potential Biomarker for Early Adjunctive Diagnosis and Prognostic Evaluation of Sepsis in Critically Ill Patients: A Prospective Cohort Study

MedComm, Volume 7, Issue 10, October 2026.
Here, we report that nuclear membrane CD63 (nmCD63), a marker of targeted nuclear degranulation in neutrophils, represents a novel biomarker for sepsis. In a two‐center prospective cohort with independent external validation, nmCD63 outperforms CRP and PCT for early sepsis diagnosis, with the nmCD63+SOFA combined model reaching an AUC of 0.943.
Xingxin Gao, Min Zhang, Linbin Li, Haihua Lyu, Zhihao Liu, Xucheng Wei, Dehui Li, Yiming Shao   +7 more
wiley   +1 more source

Pediatric patients with cancer exhibit increased neutrophil extracellular traps and reduced active deoxyribonuclease I: diagnostic, prognostic, and therapeutic opportunities. [PDF]

Clin Exp Pediatr
Benavent N, Oto J, Verger P, Herreros-Pomares A, Herranz R, Argilés B, Balaguer J, Juan-Ribelles A, Bonanad S, Medina P, Cañete A.   +10 more
europepmc   +1 more source

A Systematic Review and Meta‐Analysis of Malnutrition and Metabolic Failure in High‐Potency Incretin Therapy

Obesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Objective High‐potency incretin therapy achieved substantial weight loss, but the extreme energy deficits it induced may obscure the underlying nutritional deterioration. This meta‐analysis synthesized data from 19 randomized trials across the SURMOUNT, STEP, SCALE, and OASIS programs to quantify the nutritional and body composition ...
Eugene Ampofo, Charles Apprey, Mary Amoako, Fiifi Derrick Turkson   +3 more
wiley   +1 more source

Plasma levels of human granulocytic elastase-alpha1-proteinase inhibitor complex (E-alpha1PI) in patients with septicemia and acute leukemia [PDF]

, 1983
Werner, M., Goldberg, D. M., Hiller, E., Jochum, Marianne, Fritz, Hans, Duswald, Karl-Heimo   +5 more
core   +1 more source

Human Neutrophil Elastase and the Protein-Storm Axis: Reversible Synthetic Inhibitors in Inflammatory Disease. [PDF]

Molecules
Viglio S, Grignano MA, Gregorini M, Rampino T, Pietrocola G, Iadarola P.   +5 more
europepmc   +1 more source

Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

European Respiratory Journal, 2015
L. Garratt, E. Sutanto, K. Ling, K. Looi, T. Iosifidis, K. Martinovich, N. Shaw, E. Kicic-Starcevich, D. Knight, S. Ranganathan, S. Stick, A. Kicic   +11 more
semanticscholar   +1 more source

Unspecific Molecular Adsorption (UMA) Sample Preparation Method for Bottom‐up and Whole Protein Analysis: The Foundation

PROTEOMICS, Volume 26, Issue 10, Page 6-15, October 2026.
ABSTRACT The protein sample preparation methods for shotgun proteomics are nowadays well‐established unlike the ones for whole protein analysis. The goal of my work has been to create a simple methodology which provides a single uncomplicated sample preparation tool for these two fields. Nowadays the bulk of proteomics work is done using detergents for
Alexandre Zougman
wiley   +1 more source

Multi-Target Restoration of Dermal Elastic Fibers Through Elastin Upregulation, Elastase Suppression, and Scaffold Reinforcement. [PDF]

Curr Issues Mol Biol
Ye S, Kang S, Jeong ET, Jun SH, Kang NG.
europepmc   +1 more source

EvoMut: A computational framework for engineering oxidative stability in proteins

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Amino acid oxidation is a major cause of protein instability and loss of function in therapeutic and industrial settings. Although methionine, cysteine, tryptophan, tyrosine, histidine, lysine, and arginine residues are widely recognized as oxidation‐prone, only a subset of such residues is dominant functional hotspots, and not all are ...
Seyed Shahriar Arab, Chenlin Hsieh, Nathan E. Lewis   +2 more
wiley   +1 more source

NETosis Markers, Such as Citrullinated Histones, Myeloperoxidase, and Elastase, should not be Recommended as Predictors of COVID-19 Severity. [PDF]

Indian J Crit Care Med
Finsterer J.
europepmc   +1 more source