Results 41 to 50 of about 87,970 (343)

Faecal elastase 1   Reply [PDF]

Gut, 1997
Editor,—I read with interest a recent study by Loser et al ( Gut 1996; 39: 580–6). This detailed and well designed study compares a new tubeless test of pancreatic function, faecal pancreatic elastase 1 (FPE1) assay, against the secretin test which is the accepted gold standard pancreatic function test.
S. T AMANN, P. P TOSKES, C. LOSER, A MOLLGAARD, U R FOLSCH   +4 more
openaire   +2 more sources

Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation.
Chongyang Zhang, Amy Mohan, Hangchuan Shi, Chen Yan   +3 more
doaj   +1 more source

Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2017
Determination of fecal pancreatic elastase content by ELISA is a reliable, noninvasive clinical test for assessing exocrine pancreatic function. Despite the widespread use of commercial tests, their exact molecular targets remain poorly characterized.
Tóth Anna Zsófia, Szabó András, Hegyi Eszter, Hegyi Péter, Sahin-Tóth Miklós   +4 more
openaire   +4 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Differential Inhibition of Human Neutrophil Elastase and Bacterial Elastase by endogenous Protease Inhibitors

Journal of Clinical and Biomedical Sciences, 2018
Human Neutrophil Elastase (HNE) is released from neutrophils when foreign substances are encoun-tered. Elastase is also released by invasive pathogenic microorganisms and is an important virulence factor.
Deena Mendez, Prasad SR, Kutty AVM
doaj   +1 more source

Evaluation of proteolytic activity and serine proteases distribution in plasma from patients with bladder cancer

Frontiers in Medicine, 2023
BackgroundBladder cancer (BC) is an aggressive disease with a poor prognosis. A bladder tumor, like other malignant neoplasms, is characterized by the presence of both cancer cells and stromal cells which secrete cytokines, chemokines, growth factors ...
Tatyana Synelnyk, Tetiana Vovk, Tetiana Halenova, Valentyn Tytarenko, Nataliia Raksha, Olexii Savchuk, Tetyana Falalyeyeva, Liudmyla Ostapchenko, Pavel Yakovlev, Marko Kozyk, Dominic Thorley, Kateryna Strubchevska   +11 more
doaj   +1 more source

Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice

Journal of Neuroinflammation, 2017
BackgroundA subset of osteoarthritis (OA) patients experience joint pain with neuropathic characteristics. Mediators such as neutrophil elastase, a serine proteinase, may be released during acute OA inflammatory flares.
Milind M. Muley, E. Krustev, A. Reid, J. McDougall   +3 more
semanticscholar   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

The Cosmeceutical Potential of the Yellow-Green Alga Trachydiscus minutus Aqueous Extract: Preparation of a Natural-Based Dermal Formula as a Proof of Concept

Cosmetics, 2023
In the present study, selected cosmeceutical properties of aqueous extracts from the microalgae strain Trachydiscus minutus were assessed and compared with those obtained using three widely used Chlorella strains (C. vulgaris, C.
Nikolaos D. Georgakis, Elisavet Ioannou, Marianna Chatzikonstantinou, Marián Merino, Evangelia G. Chronopoulou, José Luis Mullor, Panagiotis Madesis, Nikolaos E. Labrou   +7 more
doaj   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source