Results 41 to 50 of about 126,008 (360)

Assessing the Impact of the Leader Peptide in Protease Inhibition by the Microviridin Family of RiPPs

Biomedicines
Background: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing class of natural products biosynthesized from a genetically encoded precursor peptide.
Jillian L. Stafford, Veronica K. Montoya, Jeffrey J. Bierman, Mark C. Walker   +3 more
doaj   +1 more source

Antioxidant and Antiaging Potential of Salak Fruit Extract (Salacca zalacca (Gaert.)Voss)

Majalah Obat Tradisional, 2023
Natural skin aging is indicated by a loss of skin structure and integrity caused by external factors including UV exposure. This exposure causes oxidative stress on skin cells, initiates aging, and degradation of extracellular matrix (ECM) structure ...
Wahyu Widowati, Dani Dani, Vera Vera, Viranda Andria Yuninda   +3 more
doaj   +1 more source

Elastases and Elastin Degradation.

Journal of Investigative Dermatology, 1982
The metabolic turnover of mature elastin fibers in adult animals is relatively slow. Although only small amounts of elastin are degraded normally, increased degradation and fragmentation of elastic fibers may play a significant role in disease processes. Elastinolytic enzymes are found in microorganisms, snake venoms, and in a number of mammalian cells
Werb, Zena, Banda, Michael J., Mckerrow, James H., Sandhaus, Robert A.   +3 more
openaire   +2 more sources

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology

Frontiers in Cardiovascular Medicine, 2022
BackgroundAbdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies of aneurysm ...
Stephanie Morgan, Lang Ho Lee, Arda Halu, Arda Halu, Jessica S. Nicolau, Hideyuki Higashi, Anna H. Ha, Jennifer R. Wen, Alan Daugherty, Peter Libby, Scott J. Cameron, Doran Mix, Elena Aikawa, Elena Aikawa, A. Phillip Owens, Sasha A. Singh, Masanori Aikawa, Masanori Aikawa, Masanori Aikawa   +18 more
doaj   +1 more source

Dual‐Layer Living Hydrogel Enables On‐Demand Delivery of Phages and Probiotics for Synergistic Wound Infection Therapy

Advanced Functional Materials, EarlyView.
A dual‐layer living hydrogel, ProΦGel, integrates bacteriophages and probiotics for synergistic wound infection therapy. The outer gelatin‐based matrix releases phages on demand in response to P. aeruginosa infections, while inner alginate beads sustain probiotic delivery.
Siyuan Tao, Darine D'Adam, Anna Hu, Sixuan Zhang, Josua Roduner, Katharina Maniura‐Weber, Qun Ren   +6 more
wiley   +1 more source

Screening and Evaluation of Dermo-Cosmetic Activities of the Invasive Plant Species Polygonum cuspidatum

Plants, 2022
Polygonum cuspidatum (P. cuspidatum) is among the world’s most problematic invasive plant species with negative ecological, socio-economic and security consequences. Management operations in areas invaded systematically generate a large quantity of plant
Vanille Quinty, Cyril Colas, Rouba Nasreddine, Reine Nehmé, Christine Piot, Micheline Draye, Emilie Destandau, David Da Silva, Gregory Chatel   +8 more
doaj   +1 more source

Zinc‐Containing Bioactive Glass Programs Macrophage Polarization through Extracellular Traps Regulation for Enhanced Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun, XueBo Wei, ZhuoYang Song, JunJun Luo, JingYi Ye, YinNan Zhang, LiFei Zhu, Jie Gao, Hongyu Zhang, Hong Zhu, Xin Wang, Ke Xu   +11 more
wiley   +1 more source

The elastase and melanogenesis inhibitory and anti-inflammatory activities of phosvitin phosphopeptides produced using high-temperature and mild-pressure (HTMP) pretreatment and enzyme hydrolysis combinations

Poultry Science, 2023
: This study aimed to determine the skin protective effect of egg yolk phosvitin phosphopeptides (PPPs). Phosvitin was separated from the egg yolk, and PPPs were produced using high-temperature and mild-pressure (HTMP) pretreatment and enzyme ...
Ji-Eun Lee, Bong Jeun An, Cheorun Jo, Byungrok Min, Hyun-Dong Paik, Dong Uk Ahn   +5 more
doaj   +1 more source

Biofilm‐Antagonist Ginger‐Based 3D‐Printable Photoresins for Complex Implant Designs Exhibiting Advanced Multifunctional Biomedical Applications

Advanced Materials, EarlyView.
This work offers unique Ginger‐based 3D‐printable resins that can print customizable high‐resolution complex designs. The customizable printing backbone of Zingerol prints also mimics various human bones' strength. Acquisition of in‐vivo biocompatibility in rat model with no severe inflammatory response, along with in‐vitro antioxidant and ex‐vivo anti‐
Simran Jindal, Majd Bisharat, Bassma Khamaisi, Krishanu Ghosal, Eid Nassar‐Marjiya, Qi Wu, Shadi Daoud, Idan Redenski, Samer Srouji, Shady Farah   +9 more
wiley   +1 more source

Differential Inhibition of Human Neutrophil Elastase and Bacterial Elastase by endogenous Protease Inhibitors

Journal of Clinical and Biomedical Sciences, 2018
Human Neutrophil Elastase (HNE) is released from neutrophils when foreign substances are encoun-tered. Elastase is also released by invasive pathogenic microorganisms and is an important virulence factor.
Deena Mendez, Prasad SR, Kutty AVM
doaj   +1 more source