Results 91 to 100 of about 14,114 (244)

Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers

Chemistry – A European Journal, EarlyView.
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley   +1 more source

Synthesis of Telechelic‐Type Polypeptides Functionalized with Aromatic Units and the Characterization of Their Structures and Thermal Properties

Macromolecular Rapid Communications, EarlyView.
Polypeptide chains were extended from both ends of aromatic diamines by chemoenzymatic polymerization, resulting in the synthesis of telechelic polyglycines (TPG) and polyalanines (TPA). These telechelic polymers assembled into branched nanofibrils through π‐π stacking of aromatic rings, with the polymer backbones bent at the aromatic unit.
Yusuke Ueno, Kousuke Tsuchiya, Hiroyasu Masunaga, Keiji Numata   +3 more
wiley   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Tailoring Multiphasic Protein Condensates via Liquid‐Liquid Phase Separation

Aggregate, Volume 7, Issue 4, April 2026.
Multiphasic protein condensates transform structural organizations and deliver nucleic acids. ABSTRACT Many of the membraneless organelles inside cells are multiphasic condensates with complex structural organizations driven by the demixing of phase‐separating proteins.
Yongxu Han, Kai Cheng, Kongqi Chen, Zhiyi Xu, Hao Jiang, Bin Zeng, Manjia Li, Fei Sun, Xiangze Zeng, Sijie Chen, Jiang Xia   +10 more
wiley   +1 more source

Computer-aided design of elastin-like polypeptides with controlled viscoelastic and structural properties [PDF]

, 2022
Diego López Barreiro, Abel Folch‐Fortuny, Iain Muntz, Jens Thies, Cees M. J. Sagt, Gijsje H. Koenderink   +5 more
openalex   +1 more source

Targeting prostate cancer cells with hybrid elastin-like polypeptide/liposome nanoparticles

International Journal of Nanomedicine, 2018
Wei Zhang,1 Yunmei Song,1 Preethi Eldi,1 Xiuli Guo,2 John D Hayball,1,3 Sanjay Garg,1 Hugo Albrecht1 1Centre for Pharmaceutical Innovation and Development, Centre for Drug Discovery and Development, Experimental Therapeutics Laboratory, Sansom Institute
Zhang W, Song Y, Eldi P, Guo X, Hayball JD, Garg S, Albrecht H   +6 more
doaj  

Thermally targeted delivery of a c-Myc inhibitory polypeptide inhibits tumor progression and extends survival in a rat glioma model. [PDF]

PLoS ONE, 2013
Treatment of glioblastoma is complicated by the tumors' high resistance to chemotherapy, poor penetration of drugs across the blood brain barrier, and damaging effects of chemotherapy and radiation to normal neural tissue.
Gene L Bidwell, Eddie Perkins, Joshua Hughes, Majid Khan, Judy R James, Drazen Raucher   +5 more
doaj   +1 more source

Novel silk fibroin/elastin wound dressings [PDF]

, 2012
Silk fibroin (SF) and elastin (EL) scaffolds were successfully produced for the first time for the treatment of burn wounds. The self-assembly properties of SF, together with the excellent chemical and mechanical stability and biocompatibility, were ...
Gomes, Andreia, Paulo, Artur Cavaco, Vasconcelos, Andreia   +2 more
core   +1 more source

Predicting Transition Temperatures of Elastin-Like Polypeptide Fusion Proteins [PDF]

Biomacromolecules, 2013
Elastin-like polypeptides (ELPs) are thermally sensitive peptide polymers that undergo thermally triggered phase separation and this behavior is imparted to soluble proteins when they are fused to an ELP. The transition temperature of the ELP fusion protein is observed to be different than that of a free ELP, indicating that the surface properties of ...
Trine, Christensen, Wafa, Hassouneh, Kimberley, Trabbic-Carlson, Ashutosh, Chilkoti   +3 more
openaire   +2 more sources

Extending the Three-Dimensional Culture of Adipocytes Through Surface Coatings

Bioengineering
To mimic the important features of progressing adiposity, in vitro adipose cell culture models must allow gradual intracellular fat accumulation in the three-dimensional (3D) arrangement of adipose-derived stem cells (ASCs) over a long-term culture ...
Sheetal Chowdhury, Komal Beeton, Zacchaeus Wallace, Maggie Moore, Gene L. Bidwell, Amol V. Janorkar   +5 more
doaj   +1 more source