Results 51 to 60 of about 756 (179)

Eldecalcitol Induces Minimodeling-Based Bone Formation and Inhibits Sclerostin Synthesis Preferentially in the Epiphyses Rather than the Metaphyses of the Long Bones in Rats. [PDF]

Int J Mol Sci
This study aimed to examine minimodeling-based bone formation between the epiphyses and metaphyses of the long bones of eldecalcitol (ELD)-administered ovariectomized rats.
Hasegawa T, Yamamoto T, Hongo H, Yamamoto T, Haraguchi-Kitakamae M, Ishizu H, Shimizu T, Saito H, Sakai S, Yogo K, Matsumoto Y, Amizuka N.   +11 more
europepmc   +2 more sources

Safety and Efficacy of Zoledronic Acid Treatment with and without Acetaminophen and Eldecalcitol for Osteoporosis

Internal Medicine, 2021
Objectives We aimed to investigate the safety of zoledronic acid (ZOL) combined with acetaminophen (APAP) regarding both the adverse events and the efficacy of ZOL combined with an eldecalcitol (ELD) in a randomized clinical trial conducted in patients with primary osteoporosis.
Mochizuki, Takeshi, Yano, Koichiro, Ikari, Katsunori, Okazaki, Ken   +3 more
openaire   +3 more sources

Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

Bone Reports, 2016
Minimodeling is a type of focal bone formation that is characterized by the lack of precedent bone erosion by osteoclasts. Although this form of bone formation has been described for more than a decade, how anti-osteoporotic agents that are currently ...
Tomohiro Hikata, Tomoka Hasegawa, Keisuke Horiuchi, Nobuyuki Fujita, Akio Iwanami, Kota Watanabe, Ken Ishii, Masaya Nakamura, Norio Amizuka, Morio Matsumoto   +9 more
doaj   +1 more source

Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats [PDF]

Journal of Endocrinology, 2015
Postmenopausal women have high incidence of cardiovascular events as estrogen deficiency can cause endothelial dysfunction. Vitamin D is reported to be beneficial on endothelial function, but it remains controversial whether vitamin D is effective for endothelial dysfunction under the treatment for osteoporosis in postmenopausal women.
Kenichi, Serizawa, Kenji, Yogo, Yoshihito, Tashiro, Satoshi, Takeda, Ryohei, Kawasaki, Ken, Aizawa, Koichi, Endo   +6 more
openaire   +2 more sources

Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines

JOR SPINE, Volume 8, Issue 4, December 2025.
The study aims to compare the effects of denosumab and bazedoxifene on spinal instrumentation surgery. CT scans obtained before and after treatment were used to generate 3D vertebral models for in silico biomechanical analysis, and mechanical loading directions—including compression and multidirectional screw forces—were applied to assess implant ...
Tomoyuki Asada, Soji Tani, Tomoko Towatari, Mahoko Ishikawa, Philip Varnadore, Yoshifumi Kudo, Peter G. Passias, Benjamin A. Alman, Koji Ishikawa   +8 more
wiley   +1 more source

Efferocytosis in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints balance “eat‐me” signals such as phosphatidylserine against inhibitory “don't‐eat‐me” cues like CD47, while TAM receptors, scavenger receptors, and integrins ...
Chaofu Li, Yukun Yang, Fating Zhou, Qiuyan Jiang, Yingying Jiang, Xuanjie Huang, Yiqiong Zhang, Zhengmeng Ye, Gang Xu, Guoying Kao, Ke Zhou, Fan Yang, Jun Xiao, Wei Wu, Chuanwei Li   +14 more
wiley   +1 more source

Active vitamin D treatment in the prevention of sarcopenia in adults with prediabetes (DPVD ancillary study): a randomised controlled trial

The Lancet. Healthy Longevity
Summary: Background: Observational studies show inverse associations between serum 25-hydroxyvitamin D concentrations and sarcopenia incidence; however, it remains unclear whether treatment with vitamin D prevents its development.
Tetsuya Kawahara, MD, Gen Suzuki, ProfMD, Shoichi Mizuno, PhD, Naoki Tominaga, MD, Mikio Toda, MD, Nagahiro Toyama, MD, Tetsuya Inazu, ProfMD, Chie Kawahara, MD, Yosuke Okada, MD, Yoshiya Tanaka, ProfMD   +9 more
doaj   +1 more source

Increased Risk of Postoperative Complications in Elderly Hip Fracture Patients With Cognitive Impairment: Evidence From a Japanese Nationwide Database

Geriatrics &Gerontology International, Volume 25, Issue 12, Page 1930-1939, December 2025.
ABSTRACT Background Hip fractures are a major cause of morbidity and mortality in the elderly. Cognitive impairment is known to be associated with poor postoperative outcomes, but its specific impact on complications following hip fracture surgery remains under‐investigated in Japan. Methods This nationwide retrospective cohort study used the Diagnosis
Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori   +6 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, Volume 58, Issue 11, November 2025.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebo-controlled study

BMJ Open, 2016
Introduction Recent research suggests that vitamin D deficiency may cause both bone diseases and a range of non-skeletal diseases. However, most of these data come from observational studies, and clinical trial data on the effects of vitamin D ...
Yoshiya Tanaka, Yosuke Okada, Tetsuya Kawahara, Gen Suzuki, Tetsuya Inazu, Shoichi Mizuno, Fumiyoshi Kasagi   +6 more
doaj   +1 more source