Results 51 to 60 of about 795 (185)

Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Skeletal system diseases, encompassing chronic disorders of the skeletal system which commonly include osteoarthritis, rheumatoid arthritis, osteoporosis and osteosarcoma. Their incidence rates have been increasing in recent years, resulting in significant social and economic burdens.
Qian Yi, Jinye Li, Guotian Luo, Jiachen Li, Dahang Yang, Wei Sun, Weichao Sun, Wei You, Lei Yang   +8 more
wiley   +1 more source

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice. [PDF]

PLoS ONE, 2018
Calcium (Ca) absorption from the intestinal tract is promoted by active vitamin D (1α,25D3). Vitamin D not only promotes Ca homeostasis, but it also inhibits bone resorption and promotes osteogenesis, thus playing a role in the maintenance of normal bone
Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano   +8 more
doaj   +1 more source

Comparative Finite Element Analysis of Denosumab and Bazedoxifene on Pedicle Screw Stability in Osteoporotic Spines

JOR SPINE, Volume 8, Issue 4, December 2025.
The study aims to compare the effects of denosumab and bazedoxifene on spinal instrumentation surgery. CT scans obtained before and after treatment were used to generate 3D vertebral models for in silico biomechanical analysis, and mechanical loading directions—including compression and multidirectional screw forces—were applied to assess implant ...
Tomoyuki Asada, Soji Tani, Tomoko Towatari, Mahoko Ishikawa, Philip Varnadore, Yoshifumi Kudo, Peter G. Passias, Benjamin A. Alman, Koji Ishikawa   +8 more
wiley   +1 more source

Examination of Risk Factors and Expression Patterns of Atypical Femoral Fractures Using the Japanese Adverse Drug Event Report Database: A Retrospective Pharmacovigilance Study

Pharmaceuticals, 2023
Atypical femoral fracture (AFF) is a rare complication related to the use of bisphosphonates (BPs). Herein, we analyzed the risk factors and onset patterns of AFF using the Japanese Adverse Drug Event Report database and reported the findings. First, the
Shinya Toriumi, Ryuji Mimori, Haruhiko Sakamoto, Hitoshi Sueki, Munehiro Yamamoto, Yoshihiro Uesawa   +5 more
doaj   +1 more source

Eldecalcitol replaces endogenous calcitriol but does not fully compensate for its action in vivo [PDF]

, 2013
Calcitriol (1α,25-dihydroxyvitamin D3, 1α,25(OH)2D3) is an essential hormone that works in cooperation with parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) to regulate calcium and phosphorus homeostasis.
Harada, Suguru, Saito, Hitoshi, サイトウ, ヒトシ, 斎藤, 一史, ハラダ, スグル, ,   +5 more
core   +1 more source

Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats [PDF]

Journal of Endocrinology, 2015
Postmenopausal women have high incidence of cardiovascular events as estrogen deficiency can cause endothelial dysfunction. Vitamin D is reported to be beneficial on endothelial function, but it remains controversial whether vitamin D is effective for endothelial dysfunction under the treatment for osteoporosis in postmenopausal women.
Kenichi, Serizawa, Kenji, Yogo, Yoshihito, Tashiro, Satoshi, Takeda, Ryohei, Kawasaki, Ken, Aizawa, Koichi, Endo   +6 more
openaire   +2 more sources

Efferocytosis in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
Efferocytosis in health and disease. Efferocytosis integrates apoptotic cell recognition, engulfment, digestion, and reprogramming to link cell clearance with tissue repair. Molecular checkpoints balance “eat‐me” signals such as phosphatidylserine against inhibitory “don't‐eat‐me” cues like CD47, while TAM receptors, scavenger receptors, and integrins ...
Chaofu Li, Yukun Yang, Fating Zhou, Qiuyan Jiang, Yingying Jiang, Xuanjie Huang, Yiqiong Zhang, Zhengmeng Ye, Gang Xu, Guoying Kao, Ke Zhou, Fan Yang, Jun Xiao, Wei Wu, Chuanwei Li   +14 more
wiley   +1 more source

Pharmacokinetic and Bioequivalence Study of Eldecalcitol Soft Capsules in Healthy Chinese Subjects

Clinical Pharmacology in Drug Development, 2022
AbstractEldecalcitol is a novel active vitamin D3 1,25(OH)2D3 derivative used in the treatment of osteoporosis. To investigate and compare the pharmacokinetic and bioequivalent profiles of two eldecalcitol soft capsule formulations at a single dose of 0.75 µg in healthy Chinese volunteers, we conducted a randomized single‐dose, open‐label, two‐period ...
Li, Ting, Sun, Feifei, Liu, Yanping, Su, Lingping, Shi, Ping, Li, Xin, Liu, Shuqin, Wang, Chenjing, Shen, Linjing, Cao, Yu, Wang, Shumin   +10 more
openaire   +2 more sources

Active vitamin D treatment in the prevention of sarcopenia in adults with prediabetes (DPVD ancillary study): a randomised controlled trial

The Lancet. Healthy Longevity
Summary: Background: Observational studies show inverse associations between serum 25-hydroxyvitamin D concentrations and sarcopenia incidence; however, it remains unclear whether treatment with vitamin D prevents its development.
Tetsuya Kawahara, MD, Gen Suzuki, ProfMD, Shoichi Mizuno, PhD, Naoki Tominaga, MD, Mikio Toda, MD, Nagahiro Toyama, MD, Tetsuya Inazu, ProfMD, Chie Kawahara, MD, Yosuke Okada, MD, Yoshiya Tanaka, ProfMD   +9 more
doaj   +1 more source

Increased Risk of Postoperative Complications in Elderly Hip Fracture Patients With Cognitive Impairment: Evidence From a Japanese Nationwide Database

Geriatrics &Gerontology International, Volume 25, Issue 12, Page 1930-1939, December 2025.
ABSTRACT Background Hip fractures are a major cause of morbidity and mortality in the elderly. Cognitive impairment is known to be associated with poor postoperative outcomes, but its specific impact on complications following hip fracture surgery remains under‐investigated in Japan. Methods This nationwide retrospective cohort study used the Diagnosis
Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori   +6 more
wiley   +1 more source