Results 31 to 40 of about 795 (185)

Eldecalcitol improves chair-rising time in postmenopausal osteoporotic women treated with bisphosphonates

Therapeutics and Clinical Risk Management, 2014
Jun Iwamoto,1 Yoshihiro Sato21Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, JapanAbstract: An open-label randomized controlled trial was conducted to ...
Iwamoto J, Sato Y
doaj   +1 more source

Effects of eldecalcitol and ibandronate on secondary osteoporosis and muscle wasting in rats with adjuvant-induced arthritis

Osteoporosis and Sarcopenia, 2018
Objectives: Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovium, progressive erosion of the articular cartilage, and joint destruction. RA also causes secondary osteoporosis and muscle wasting.
Yuichi Ono, Naohisa Miyakoshi, Yuji Kasukawa, Hiroyuki Nagasawa, Hiroyuki Tsuchie, Manabu Akagawa, Itsuki Nagahata, Yusuke Yuasa, Chiaki Sato, Yoichi Shimada   +9 more
doaj   +2 more sources

Long-Term Sequential Therapy for Pregnancy- and Lactation-Associated Osteoporosis With Multiple Vertebral Fractures: A Case Report of Over 5 Years. [PDF]

Case Rep Obstet Gynecol
Background Pregnancy‐ and lactation‐associated osteoporosis (PLO) is a rare condition that may cause multiple vertebral fractures during late pregnancy or the postpartum period. Evidence regarding treatment strategies remains limited, particularly regarding long‐term outcomes of sequential regimens combining anabolic and antiresorptive therapies.
Tsuchimochi K, Tsuchimochi H.
europepmc   +2 more sources

Clinical Pharmacist's Role in Preventing and Managing Drug-Induced Oral Ulceration: A Bisphosphonate Case in an Older Adult Care Setting. [PDF]

Case Rep Dent
Bisphosphonate‐induced oral mucosal ulcers are rare adverse events distinct from medication‐related osteonecrosis of the jaw. This case demonstrates successful conservative management through the modification of drug administration in an older adult care facility.
Sano M, Iijima Y, Yamada M, Hino S, Shinogi M, Horie N, Kaneko T.   +6 more
europepmc   +2 more sources

Comparison of Efficacy and Safety of Denosumab with Eldecalcitol or Native Vitamin D in Postmenopausal Chinese Women with Osteoporosis (ESCORT): A Randomized Controlled Trial. [PDF]

J Clin Med
Background: Eldecalcitol (ELD) and denosumab are some of the most common therapeutic options for osteoporosis management. ELD effectively increases bone mineral density (BMD) in osteoporotic patients, independent of baseline vitamin D status or calcium ...
Zeng Y, Tang Q, Yang J, Li Q, Yang L, Zhang B, Yang M, Che M, Peng Y.   +8 more
europepmc   +2 more sources

Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal

Frontiers in Pharmacology, 2023
Background: Aging and oxidative stress are considered to be the proximal culprits of postmenopausal osteoporosis. Eldecalcitol (ED-71), a new active vitamin D derivative, has shown a good therapeutic effect on different types of osteoporosis, but the ...
Yuying Kou, Yuying Kou, Xing Rong, Xing Rong, Rong Tang, Rong Tang, Yuan Zhang, Yuan Zhang, Panpan Yang, Panpan Yang, Hongrui Liu, Hongrui Liu, Wanli Ma, Wanli Ma, Minqi Li, Minqi Li   +15 more
doaj   +1 more source

A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures : A randomized, active comparator, double-blind study [PDF]

, 2011
Background: Eldecalcitol is an analog of 1,25-dihydroxyvitamin D3 that improves bone mineral density; however, the effect of eldecalcitol on the risk of fractures is unclear.
Shiraki, Masataka, マツモト, トシオ, Fukunaga, Masao, 松本, 俊夫, Ito, Masako, 1591, Tanigawara, Yusuke, Hirota, Takako, Hayashi, Yasufumi, Nakamura, Toshitaka, Matsumoto, Toshio, 20157374, 60162/profile-ja.html, Sone, Teruki   +13 more
core   +2 more sources

Exploring the factors associated with difficulties in extracting tablets or capsules from press-through-package sheets. [PDF]

Br J Clin Pharmacol
Abstract Exploring factors related to difficulties in extracting tablets or capsules from press‐through‐packages is essential for optimizing the dosage form. To achieve this, the involvement of patient insight is important. In the present study, the preferences of patients regarding drugs that are difficult to extract from their packaging were ...
Tsuchiya M, Imai S, Asano M, Shimizu Y, Kizaki H, Ito Y, Tsuchiya M, Kuriyama R, Yoshida N, Shimada M, Sando T, Ishijima T, Hori S.   +12 more
europepmc   +2 more sources

Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats [PDF]

, 2011
To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model.
Kimimitsu Oda, Saito, H., Paulo Henrique Luiz de Freitas, Muneteru Sasaki, Norio Amizuka, Takeda, S., Sasaki, M., Li, M., Hitoshi Saito, Oda, K., Freitas, PHL., Tabata, C., Hasegawa, T., Amizuka, N., Minqi Li, Tomoka Hasegawa, Satoshi Takeda, Chihiro Tabata   +17 more
core   +1 more source

Table1_Eldecalcitol prevents muscle loss by suppressing PI3K/AKT/FOXOs pathway in orchiectomized mice.docx

, 2022
Elderly male patients are susceptible to develop osteoporosis and sarcopenia, especially those with fragility fractures, hypogonadism, and prostate cancer with androgen deprivation therapy.
Weijia Yu (2571583), Minmin Chen (1459078), Shuangshuang Dong (14024340), Yanping Du (795367), Haichao Zhang (221945), Qun Cheng (511514), Wenjing Tang (758876), Zheng Ke (356425)   +7 more
core   +1 more source