Results 31 to 40 of about 645 (131)

Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats [PDF]

, 2011
To elucidate the histological events that follow administration of eldecalcitol, a second-generation of vitamin D analog currently awaiting approval as a drug for treatment of osteoporosis, we employed the ovariectomy (OVX) rat model.
Kimimitsu Oda, Saito, H., Hasegawa, Tomoka, de Freitas, Paulo Henrique Luiz, Paulo Henrique Luiz de Freitas, Li, Minqi, Muneteru Sasaki, Norio Amizuka, Oda, Kimimitsu, Takeda, S., Sasaki, M., Li, M., Hitoshi Saito, Sasaki, Muneteru, Oda, K., Freitas, PHL., Takeda, Satoshi, Amizuka, Norio, Tabata, C., Hasegawa, T., Amizuka, N., Minqi Li, Tabata, Chihiro, Tomoka Hasegawa, Satoshi Takeda, Chihiro Tabata, Saito, Hitoshi   +26 more
core   +1 more source

Novel, Practical, and Scalable Approach for the Synthesis of Eldecalcitol

, 2023
A novel, practical, and scalable approach for the synthesis of eldecalcitol (2), via the Horner–Wadsworth–Emmons (HWE) olefination of A-ring and C/D-ring fragments, has been described.
Ren-xiang Tan, Hai-feng Ji (16033295), Lei Li, Xiao-long Wang, Lei Li (29537), Jian Zhou (28020), Zhen-jiang Tong (16033301), Xiao-long Wang (3062151), Ai-ping Chen, Xiao-long Jiang, Jian Zhou, Xian-kai Meng (16033298), Ren-xiang Tan (16033289), Zhen-jiang Tong, Ai-ping Chen (16033286), Xiao-long Jiang (16033292), Hai-feng Ji, Yan-cheng Yu, Yan-cheng Yu (16033304), Xian-kai Meng   +19 more
core   +1 more source

Table1_Eldecalcitol prevents muscle loss by suppressing PI3K/AKT/FOXOs pathway in orchiectomized mice.docx

, 2022
Elderly male patients are susceptible to develop osteoporosis and sarcopenia, especially those with fragility fractures, hypogonadism, and prostate cancer with androgen deprivation therapy.
Weijia Yu (2571583), Minmin Chen (1459078), Shuangshuang Dong (14024340), Yanping Du (795367), Haichao Zhang (221945), Qun Cheng (511514), Wenjing Tang (758876), Zheng Ke (356425)   +7 more
core   +1 more source

Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

Bone Reports, 2021
Combination therapy of active vitamin D3 with some bisphosphonates (BPs) has been reported to be clinically beneficial. However, combination therapy of eldecalcitol (ELD) with BP has to date not been validated as to whether it is beneficial in the ...
Tetsuo Yano, Teppei Ito, Yuya Kanehira, Mei Yamada, Hiromi Kimura-Suda, Hirotaka Wagatsuma, Daisuke Inoue   +6 more
doaj   +1 more source

Eldecalcitol Induces Minimodeling-Based Bone Formation and Inhibits Sclerostin Synthesis Preferentially in the Epiphyses Rather than the Metaphyses of the Long Bones in Rats. [PDF]

Int J Mol Sci
This study aimed to examine minimodeling-based bone formation between the epiphyses and metaphyses of the long bones of eldecalcitol (ELD)-administered ovariectomized rats.
Hasegawa T, Yamamoto T, Hongo H, Yamamoto T, Haraguchi-Kitakamae M, Ishizu H, Shimizu T, Saito H, Sakai S, Yogo K, Matsumoto Y, Amizuka N.   +11 more
europepmc   +2 more sources

ED-71 Prevents Glucocorticoid-Induced Osteoporosis by Regulating Osteoblast Differentiation via Notch and Wnt/β-Catenin Pathways

Drug Design, Development and Therapy, 2022
Xing Rong,1,2 Yuying Kou,1,2 Yuan Zhang,1,2 Panpan Yang,1,2 Rong Tang,1,2 Hongrui Liu,1,2 Minqi Li1,2 1Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral ...
Rong X, Kou Y, Zhang Y, Yang P, Tang R, Liu H, Li M   +6 more
doaj  

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice. [PDF]

PLoS ONE, 2018
Calcium (Ca) absorption from the intestinal tract is promoted by active vitamin D (1α,25D3). Vitamin D not only promotes Ca homeostasis, but it also inhibits bone resorption and promotes osteogenesis, thus playing a role in the maintenance of normal bone
Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano   +8 more
doaj   +1 more source

Examination of Risk Factors and Expression Patterns of Atypical Femoral Fractures Using the Japanese Adverse Drug Event Report Database: A Retrospective Pharmacovigilance Study

Pharmaceuticals, 2023
Atypical femoral fracture (AFF) is a rare complication related to the use of bisphosphonates (BPs). Herein, we analyzed the risk factors and onset patterns of AFF using the Japanese Adverse Drug Event Report database and reported the findings. First, the
Shinya Toriumi, Ryuji Mimori, Haruhiko Sakamoto, Hitoshi Sueki, Munehiro Yamamoto, Yoshihiro Uesawa   +5 more
doaj   +1 more source

Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats

Glucocorticoid causes secondary osteoporosis and myopathy, characterized by type II muscle fiber atrophy. We examined whether a new vitamin D3 analog, eldecalcitol, could inhibit glucocorticoid-induced osteopenia or myopathy in rats and determined ...
Shiraishi, Ayako, Fujii, Masashi, Sakai, Sadaoki, Segawa, Toyohito, Ohuchi, Kentaro, Shimada, Yoichi, Miyakoshi, Naohisa, Kinoshita, Hayato, Kasukawa, Yuji, Sato, Chie   +9 more
core   +2 more sources

Histomorphometric analysis of minimodeling in the vertebrae in postmenopausal patients treated with anti-osteoporotic agents

Bone Reports, 2016
Minimodeling is a type of focal bone formation that is characterized by the lack of precedent bone erosion by osteoclasts. Although this form of bone formation has been described for more than a decade, how anti-osteoporotic agents that are currently ...
Tomohiro Hikata, Tomoka Hasegawa, Keisuke Horiuchi, Nobuyuki Fujita, Akio Iwanami, Kota Watanabe, Ken Ishii, Masaya Nakamura, Norio Amizuka, Morio Matsumoto   +9 more
doaj   +1 more source