Results 21 to 30 of about 756 (179)

Effects of eldecalcitol on cortical bone response to mechanical loading in rats [PDF]

BMC Musculoskeletal Disorders, 2015
Mechanical loading of bones activates modeling and suppresses remodeling by promoting bone formation. Eldecalcitol is approved for the treatment of osteoporosis in Japan and is often used in patients undergoing exercise therapy. However, the effects of eldecalcitol on bone formation during mechanical loading are unknown.
Yamasaki, Yusuke, Nagira, Keita, Osaki, Mari, Nagashima, Hideki, Hagino, Hiroshi   +4 more
core   +5 more sources

Effectiveness of monthly intravenous ibandronate injections in a real-world setting: Subgroup analysis of a postmarketing observational study

Osteoporosis and Sarcopenia, 2019
Objectives: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis.
Yasuhiro Takeuchi, Junko Hashimoto, Hiroyuki Kakihata, Yousuke Nishida, Michiko Kumagai, Chiemi Yamagiwa   +5 more
doaj   +2 more sources

Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis [PDF]

Frontiers in Endocrinology
BackgroundElderly people are at high risk of falls due to decreased muscle strength. So far, there is currently no officially approved medication for treating muscle strength loss.
An Xiong, Haibo Li, Miaoying Lin, Feng Xu, Xuedi Xia, Dexing Dai, Ruoman Sun, Yali Ling, Lei Qiu, Rui Wang, Ya Ding, Zhongjian Xie   +11 more
doaj   +2 more sources

Combined Use of Ibandronate and Eldecalcitol in Postmenopausal Japanese Women with Osteoporosis [PDF]

Journal of Orthopaedic Surgery, 2016
Purpose To evaluate the effect of combined use of ibandronate and eldecalcitol for 6 to 12 months on bone mineral density (BMD) and bone strength of the proximal femur in postmenopausal Japanese women with osteoporosis.
Junichi Takada, Hiroshi Wada, Kousuke Iba, Kouichi Sasaki, Takayuki Dohke, Kumiko Kanaya, Takashi Yoshizaki, Toshihiko Yamashita   +7 more
doaj   +3 more sources

A pharmacovigilance study on clinical factors of active vitamin D3 analog-related acute kidney injury using the Japanese Adverse Drug Event Report Database [PDF]

Scientific Reports
Acute kidney injury (AKI) due to vitamin D therapy for osteoporosis is encountered in clinical practice, but epidemiological studies are scarce. We aimed to determine the association between AKI and vitamin D therapy and to identify risk factors for AKI ...
Yuki Kawai, Kazushi Uneda, Satoshi Miyata, Ayana Kunii, Shohei Nagayama, Kenji Baba, Tamio Iwamoto   +6 more
doaj   +2 more sources

Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials

Drug Design, Development and Therapy, 2016
Zhixing Xu,1 Changchun Fan,2 Xuechun Zhao,3 Hairong Tao1 1Department of Orthopedic Surgery, The Third People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; 2Department of ...
Xu Z, Fan C, Zhao X, Tao H
doaj   +1 more source

ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis [PDF]

Drug Design, Development and Therapy
Ke Wang,1,2,3 Yuying Kou,4 Xing Rong,1,2 Lingling Wei,5 Jingyuan Li,6 Hongrui Liu,1,2 Minqi Li,1,2 Hui Song31Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &
Wang K, Kou Y, Rong X, Wei L, Li J, Liu H, Li M, Song H   +7 more
doaj   +2 more sources

Eldecalcitol improves chair-rising time in postmenopausal osteoporotic women treated with bisphosphonates

Therapeutics and Clinical Risk Management, 2014
Jun Iwamoto,1 Yoshihiro Sato21Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Neurology, Mitate Hospital, Fukuoka, JapanAbstract: An open-label randomized controlled trial was conducted to ...
Iwamoto J, Sato Y
doaj   +1 more source

Comparison of effectiveness and safety of ibandronate and minodronate combined with eldecalcitol in primary osteoporosis of women: A 1-year follow-up study

Osteoporosis and Sarcopenia, 2017
Objectives: This is an open labeled and retrospective cohort study which compared the effectiveness and safety of ibandronate (IBN) and minodronate (MIN) combined with eldecalcitol (ELD) in primary osteoporosis of women.
Mizue Tanaka, Yukio Nakamura, Soichiro Itoh, Yoshiharu Kato   +3 more
doaj   +2 more sources

Effects of eldecalcitol and ibandronate on secondary osteoporosis and muscle wasting in rats with adjuvant-induced arthritis

Osteoporosis and Sarcopenia, 2018
Objectives: Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovium, progressive erosion of the articular cartilage, and joint destruction. RA also causes secondary osteoporosis and muscle wasting.
Yuichi Ono, Naohisa Miyakoshi, Yuji Kasukawa, Hiroyuki Nagasawa, Hiroyuki Tsuchie, Manabu Akagawa, Itsuki Nagahata, Yusuke Yuasa, Chiaki Sato, Yoichi Shimada   +9 more
doaj   +2 more sources