Results 11 to 20 of about 645 (131)

Protocol for a randomized study of the efficacy of ibandronic acid plus eldecalcitol in patients with gastric cancer after gastrectomy: A comparative study of different routes of administration of ibandronic acid [version 2; peer review: 2 approved] [PDF]

F1000Research, 2023
Background: Patients who undergo gastrectomy for gastric cancer are susceptible to osteoporosis. To prevent a decrease in bone mineral density, an appropriate prophylaxis is considered important to adjust the post-gastrectomy condition. In this study, we
Hideki Murakami, Sunao Ito, Shuji Takiguchi, Yuichiro Mizuno, Tomotaka Okubo, Takuya Usami, Yuta Goto, Hiroaki Kimura, Jumpei Inoue, Hiroyuki Sagawa, Hiroya Hashimoto, Hisaki Aiba, Nobuyuki Suzuki   +12 more
doaj   +2 more sources

The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis

Medicina, 2023
Background and Objectives: The incidence of diabetic osteoporosis, an important complication of diabetes mellitus, is increasing gradually. This study investigated the combined effect of the Zuogui pill (ZGP) and eldecalcitol (ED-71), a novel vitamin D ...
Tuo Shi, Ting Liu, Yuying Kou, Xing Rong, Lingxiao Meng, Yajun Cui, Ruihan Gao, Sumin Hu, Minqi Li   +8 more
doaj   +2 more sources

Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice

Experimental Gerontology
Background: Active vitamin D analog eldecalcitol is clinically applied in treatment of postmenopausal osteoporosis. This study aims to determine the role of eldecalcitol in the protection of osteocytes from senescence and the associated ferroptosis ...
Yong-Fang Fu, Yi-Xun Guo, Shi-Hui Xia, Ting-Ting Zhou, Yun-Chao Zhao, Zhen-Hua Jia, Yan Zhang   +6 more
doaj   +2 more sources

Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia

Case Reports in Nephrology, 2019
An 82-year-old man treated with phenytoin for the prevention of symptomatic epilepsy was hospitalized to treat consciousness disturbance, seizure, and hypocalcemia (serum calcium: 4.6 mg/dL).
Seishi Aihara, Shunsuke Yamada, Mika Kondo, Hideaki Oka, Taro Kamimura, Atsumi Harada, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono   +8 more
doaj   +2 more sources

Inhibition of vitamin D analog eldecalcitol on hepatoma in vitro and in vivo

Open Medicine, 2020
Hepatoma is a serious liver cancer with high morbidity and mortality. Eldecalcitol (ED-71), a vitamin D analog, is extensively used as anti-cancer agent in vitro. Hepatocellular carcinoma cell, SMMC-7721 cell lines were used in this study.
Ye Limin, Zhu Liyi, Wang Jinglin, Li Fei
doaj   +2 more sources

Eldecalcitol for the treatment of osteoporosis

Clinical Interventions in Aging, 2013
Yuko Noguchi, Hisaya Kawate, Masatoshi Nomura, Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanAbstract: Eldecalcitol (1α, 25-dihydroxy-2β-[3 ...
Noguchi Y, Kawate H, Nomura M, Takayanagi R   +3 more
doaj   +1 more source

Two-year effectiveness of zoledronic acid with or without eldecalcitol in Japanese patients with osteoporosis: A randomized prospective study

Osteoporosis and Sarcopenia, 2022
Objectives: This study aims to examine the 2-year outcomes of zoledronic acid (ZOL) with or without eldecalcitol (ELD) on bone mineral density (BMD) and fracture in Japanese patients with osteoporosis.
Takeshi Mochizuki, Koichiro Yano, Katsunori Ikari, Ken Okazaki   +3 more
doaj   +2 more sources

Effectiveness of monthly intravenous ibandronate injections in a real-world setting: Subgroup analysis of a postmarketing observational study

Osteoporosis and Sarcopenia, 2019
Objectives: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis.
Yasuhiro Takeuchi, Junko Hashimoto, Hiroyuki Kakihata, Yousuke Nishida, Michiko Kumagai, Chiemi Yamagiwa   +5 more
doaj   +2 more sources

ED-71 Improves Bone Mass in Ovariectomized Rats by Inhibiting Osteoclastogenesis Through EphrinB2-EphB4-RANKL/OPG Axis [PDF]

Drug Design, Development and Therapy
Ke Wang,1,2,3 Yuying Kou,4 Xing Rong,1,2 Lingling Wei,5 Jingyuan Li,6 Hongrui Liu,1,2 Minqi Li,1,2 Hui Song31Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University &
Wang K, Kou Y, Rong X, Wei L, Li J, Liu H, Li M, Song H   +7 more
doaj   +2 more sources

A pharmacovigilance study on clinical factors of active vitamin D3 analog-related acute kidney injury using the Japanese Adverse Drug Event Report Database [PDF]

Scientific Reports
Acute kidney injury (AKI) due to vitamin D therapy for osteoporosis is encountered in clinical practice, but epidemiological studies are scarce. We aimed to determine the association between AKI and vitamin D therapy and to identify risk factors for AKI ...
Yuki Kawai, Kazushi Uneda, Satoshi Miyata, Ayana Kunii, Shohei Nagayama, Kenji Baba, Tamio Iwamoto   +6 more
doaj   +2 more sources