Results 11 to 20 of about 795 (185)

Eldecalcitol for the treatment of osteoporosis

Clinical Interventions in Aging, 2013
Yuko Noguchi, Hisaya Kawate, Masatoshi Nomura, Ryoichi TakayanagiDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanAbstract: Eldecalcitol (1α, 25-dihydroxy-2β-[3 ...
Noguchi Y, Kawate H, Nomura M, Takayanagi R   +3 more
doaj   +11 more sources

Inhibition of vitamin D analog eldecalcitol on hepatoma in vitro and in vivo [PDF]

Open Medicine, 2020
Hepatoma is a serious liver cancer with high morbidity and mortality. Eldecalcitol (ED-71), a vitamin D analog, is extensively used as anti-cancer agent in vitro. Hepatocellular carcinoma cell, SMMC-7721 cell lines were used in this study.
Ye Limin, Zhu Liyi, Wang Jinglin, Li Fei
doaj   +4 more sources

Combined Use of Ibandronate and Eldecalcitol in Postmenopausal Japanese Women With Osteoporosis [PDF]

Journal of Orthopaedic Surgery, 2016
Purpose To evaluate the effect of combined use of ibandronate and eldecalcitol for 6 to 12 months on bone mineral density (BMD) and bone strength of the proximal femur in postmenopausal Japanese women with osteoporosis.
Kousuke Iba, Toshihiko Yamashita, Takayuki Dohke   +2 more
exaly   +4 more sources

Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid treated rats [PDF]

Journal of Bone and Mineral Metabolism, 2015
Glucocorticoid causes secondary osteoporosis and myopathy, characterized by type II muscle fiber atrophy. We examined whether a new vitamin D3 analog, eldecalcitol, could inhibit glucocorticoid-induced osteopenia or myopathy in rats and determined ...
Shiraishi, Ayako, Fujii, Masashi, Sakai, Sadaoki, Segawa, Toyohito, Ohuchi, Kentaro, Shimada, Yoichi, Miyakoshi, Naohisa, Kinoshita, Hayato, Kasukawa, Yuji, Sato, Chie   +9 more
core   +4 more sources

Protocol for a randomized study of the efficacy of ibandronic acid plus eldecalcitol in patients with gastric cancer after gastrectomy: A comparative study of different routes of administration of ibandronic acid [version 2; peer review: 2 approved] [PDF]

F1000Research, 2023
Background: Patients who undergo gastrectomy for gastric cancer are susceptible to osteoporosis. To prevent a decrease in bone mineral density, an appropriate prophylaxis is considered important to adjust the post-gastrectomy condition. In this study, we
Hideki Murakami, Sunao Ito, Shuji Takiguchi, Yuichiro Mizuno, Tomotaka Okubo, Takuya Usami, Yuta Goto, Hiroaki Kimura, Jumpei Inoue, Hiroyuki Sagawa, Hiroya Hashimoto, Hisaki Aiba, Nobuyuki Suzuki   +12 more
doaj   +2 more sources

The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis

Medicina, 2023
Background and Objectives: The incidence of diabetic osteoporosis, an important complication of diabetes mellitus, is increasing gradually. This study investigated the combined effect of the Zuogui pill (ZGP) and eldecalcitol (ED-71), a novel vitamin D ...
Tuo Shi, Ting Liu, Yuying Kou, Xing Rong, Lingxiao Meng, Yajun Cui, Ruihan Gao, Sumin Hu, Minqi Li   +8 more
doaj   +2 more sources

Eldecalcitol protected osteocytes against ferroptosis of D-gal-induced senescent MLO-Y4 cells and ovariectomized mice

Experimental Gerontology
Background: Active vitamin D analog eldecalcitol is clinically applied in treatment of postmenopausal osteoporosis. This study aims to determine the role of eldecalcitol in the protection of osteocytes from senescence and the associated ferroptosis ...
Yong-Fang Fu, Yi-Xun Guo, Shi-Hui Xia, Ting-Ting Zhou, Yun-Chao Zhao, Zhen-Hua Jia, Yan Zhang   +6 more
doaj   +2 more sources

Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia

Case Reports in Nephrology, 2019
An 82-year-old man treated with phenytoin for the prevention of symptomatic epilepsy was hospitalized to treat consciousness disturbance, seizure, and hypocalcemia (serum calcium: 4.6 mg/dL).
Seishi Aihara, Shunsuke Yamada, Mika Kondo, Hideaki Oka, Taro Kamimura, Atsumi Harada, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono   +8 more
doaj   +2 more sources

Effectiveness of monthly intravenous ibandronate injections in a real-world setting: Subgroup analysis of a postmarketing observational study

Osteoporosis and Sarcopenia, 2019
Objectives: The favorable safety and consistent effectiveness of monthly intravenous (IV) ibandronate injections was demonstrated in a prospective, postmarketing, observational study in Japanese patients with osteoporosis.
Yasuhiro Takeuchi, Junko Hashimoto, Hiroyuki Kakihata, Yousuke Nishida, Michiko Kumagai, Chiemi Yamagiwa   +5 more
doaj   +2 more sources

Novel, Practical, and Scalable Approach for the Synthesis of Eldecalcitol

Organic Process Research & Development, 2023
A novel, practical, and scalable approach for the synthesis of eldecalcitol (2), via the Horner–Wadsworth–Emmons (HWE) olefination of A-ring and C/D-ring fragments, has been described.
Ren-xiang Tan, Hai-feng Ji (16033295), Lei Li, Xiao-long Wang, Lei Li (29537), Jian Zhou (28020), Zhen-jiang Tong (16033301), Xiao-long Wang (3062151), Ai-ping Chen, Xiao-long Jiang, Jian Zhou, Xian-kai Meng (16033298), Ren-xiang Tan (16033289), Zhen-jiang Tong, Ai-ping Chen (16033286), Xiao-long Jiang (16033292), Hai-feng Ji, Yan-cheng Yu, Yan-cheng Yu (16033304), Xian-kai Meng   +19 more
core   +2 more sources