Results 121 to 130 of about 3,308,023 (394)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
BMC Family Practice, 2018 Background Adherence to osteoporosis treatment is crucial for good treatment effects. However, adherence has been shown to be poor and a substantial part of the patients don’t even initiate treatment.
Karin M. A. Swart +7 more
doaj +1 more source
The case of public transport infrastructure in Malta, and its impact on the elderly [PDF]
, 2016 The concept of equity is essential in transport because inequities lead to the formation of transport-disadvantaged groups, such as the elderly, disabled and low-income people. This paper focuses on the elderly.
Bajada, Therese +2 more
core +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Motivation of the Elderly and Elderly Visits to the Elderly Integrated Service Post (Posyandu Lansia) in Klampisan Hamlet, Kedunggede Village, Dlanggu Sub-district, Mojokerto District [PDF]
, 2018 Background. Having a healthy and prosperous life in old age is the hope of every elderly person. In achieving a healthy and prosperous old age, various efforts have been made by the government, one of which is an Elderly Integrated Service Post (Posyandu
Hartono, A. (Aris) +4 more
core
Physical activity programs for balance and fall prevention in elderly
Medicine, 2019 Background: Due to demographic changes the world's population is progressively ageing. The physiological decay of the elderly adult may lead to a reduction in the ability to balance and an increased risk of falls becoming an important issue among the ...
E. Thomas +6 more
semanticscholar +1 more source
International Journal of Gerontology, 2012 SummaryElderly people are the largest and continuously fastest growing population among patients with epilepsy. Elderly patients with epilepsy are very different from other age groups in many respects and clinicians shouldn’t treat them in the same way as younger adults.
Lu-An Chen +2 more
openaire +2 more sources
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source
Psychiatric Morbidity among Elderly People Living in Old Age Homes and in the Community: A Comparative Study [PDF]
, 2012 Background: Disorders such as depression, anxiety, cognitive and psychotic disorders have a high prevalence among elderly. There is some preliminary evidence that life in old age homes is perceived by inmates as more supportive, though the issue is not ...
Majgi, SM +4 more
core
TORC1 inhibition enhances immune function and reduces infections in the elderly
Science Translational Medicine, 2018 Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates. Dialing down TORC1 dials up immunity Aging may be regulated by a discrete set of intracellular proteins including the ...
J. Mannick +11 more
semanticscholar +1 more source