Results 121 to 130 of about 3,263,574 (391)
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Understanding consumption within a residential care home : an interpretation of George’s everyday experiences of life and death [PDF]
, 2007 We are witnessing perhaps the most important shift in the history of mankind – the rapid ageing of the earths population. This trend raises such issues as elderly care giving and living arrangements in old age.
Stone, Tim
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Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
TORC1 inhibition enhances immune function and reduces infections in the elderly
Science Translational Medicine, 2018 Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates. Dialing down TORC1 dials up immunity Aging may be regulated by a discrete set of intracellular proteins including the ...
J. Mannick +11 more
semanticscholar +1 more source
Applicability of trials in rheumatoid arthritis and osteoarthritis: A systematic review and meta-analysis of trial populations showing adequate proportion of women, but underrepresentation of elderly people [PDF]
, 2018 Objectives: To evaluate whether elderly people and women are adequately represented in randomized controlled trials (RCT) in rheumatoid arthritis (RA) and osteoarthritis (OA).
Boers, Maarten +6 more
core +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
BMC SurgeryObjective Failure to understand long-term quality of life and functional outcomes hinders effective decision making and prognostication. Therefore, the study aims to predict and analyse the unfavorable outcomes (FOs) in elderly patients undergoing lumbar
Peng Cui +6 more
doaj +1 more source
BMC Geriatrics, 2019 Background Delirium is a frequent complication of hospital admission among older people. Multicomponent interventions which can reduce incident delirium by ≈one-third are recommended by the National Institute of Health and Care Excellence.
Mary Godfrey +6 more
doaj +1 more source
New England Journal of Medicine, 1994 BACKGROUND Since falling is associated with serious morbidity among elderly people, we investigated whether the risk of falling could be reduced by modifying known risk factors.
M. Tinetti +8 more
semanticscholar +1 more source
Geographic Breakdown of Georgia's Interstate Migration Patterns - Brief [PDF]
, 2006 This brief looks at the geographic breakdown of Georgia's interstate migration patterns for both the elderly and non-elderly.
Jon Rork
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