Results 121 to 130 of about 3,202,647 (392)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study

open access: yesBMC Geriatrics, 2019
Background Delirium is a frequent complication of hospital admission among older people. Multicomponent interventions which can reduce incident delirium by ≈one-third are recommended by the National Institute of Health and Care Excellence.
Mary Godfrey   +6 more
doaj   +1 more source

A multifactorial intervention to reduce the risk of falling among elderly people living in the community.

open access: yesNew England Journal of Medicine, 1994
BACKGROUND Since falling is associated with serious morbidity among elderly people, we investigated whether the risk of falling could be reduced by modifying known risk factors.
M. Tinetti   +8 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

open access: yesMolecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi   +6 more
wiley   +1 more source

Development and validation of a nomogram to predict the unfavorable outcomes in elderly patients undergoing lumbar fusion surgery for degenerative disease

open access: yesBMC Surgery
Objective Failure to understand long-term quality of life and functional outcomes hinders effective decision making and prognostication. Therefore, the study aims to predict and analyse the unfavorable outcomes (FOs) in elderly patients undergoing lumbar
Peng Cui   +6 more
doaj   +1 more source

[Review of the book \u3ci\u3eRetirement Income Opportunities in an Aging America: Income Levels and Adequacy\u3c/i\u3e] [PDF]

open access: yes, 1983
[Excerpt] The slant of this volume will not appeal to everyone. Consider the following: During the last twenty years, the elderly\u27s financial status has improved substantially. Today those who are over age 65 receive income from more sources and have
Fields, Gary S
core   +1 more source

Anaemia in the elderly. [PDF]

open access: yesBMJ, 1973
Anaemia is always pathological and the clinical impression of its presence or absence often erroneous; it is not a con comitant of ageing. The reported incidence has varied greatly. Pincherle and Shanks1 found it in only 0*42% of 2,000 busi ness executives, 300 of whom were over 60 years.
openaire   +3 more sources

TORC1 inhibition enhances immune function and reduces infections in the elderly

open access: yesScience Translational Medicine, 2018
Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates. Dialing down TORC1 dials up immunity Aging may be regulated by a discrete set of intracellular proteins including the ...
J. Mannick   +11 more
semanticscholar   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

open access: yesMolecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke   +12 more
wiley   +1 more source

Population Aging, Elderly Migration and Education Spending: Intergenerational Conflict Revisited [PDF]

open access: yes
Elderly have been increasingly targeted as a group to enhance economic development and the tax base in communities. While recent literature on elderly migration tends to focus on how elderly migration patterns are influenced by state fiscal variables ...
Tosun, Mehmet S.   +2 more
core   +3 more sources

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