Results 71 to 80 of about 1,899,131 (352)
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Relativistic electrons generated at Earth's quasi-parallel bow shock. [PDF]
, 2019 Plasma shocks are the primary means of accelerating electrons in planetary and astrophysical settings throughout the universe. Which category of shocks, quasi-perpendicular or quasi-parallel, accelerates electrons more efficiently is debated.
Angelopoulos, Vassilis +2 more
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
, 2014 Angle-resolved photoemission spectroscopy of Ca10(Ir4As8)(Fe2_xIrxAs2)5 shows that the Fe 3d electrons in the FeAs layer form the hole-like Fermi pocket at the zone center and the electron-like Fermi pockets at the zone corners as commonly seen in ...
Horiba, K. +11 more
core +1 more source
Nanomaterials, 2022 The new phenomena observed in nanodevices and the related technological challenges of fabrication and manipulation at the nanoscale have spurred intense theoretical, simulation and experimental research activity [...]
openaire +4 more sources
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Influence of 2 MeV electrons irradiation on gallium phosphide light-emitting diodes reverse currents
Ядерна фізика та енергетика, 2015 Results of reverse electrophysical characteristics study of red and green LEDs, initial and irradiated with 2 MeV electrons were given. It was found that reverse current was predominantly caused by carriers tunneling at Urev ≤ 9 V, and by the avalanche ...
V. G. Vorobiov +5 more
doaj
Resistive anode image converter [PDF]
, 1976 The invention of an apparatus for imaging soft X-ray and ultraviolet electromagnetic radiation and charged particles was described. The apparatus includes a pair of microchannel electron multiplier plates connected in a cascaded chevron configuration ...
Lampton, M. L., Paresce, F.
core +1 more source
Escape of cosmic-ray electrons from supernova remnants
, 2012 We investigate escape of cosmic ray (CR) electrons from a supernova remnant (SNR) to interstellar space. We show that CR electrons escape in order from high energies to low energies like CR nuclei, while the escape starts later than the beginning of the ...
Abdo +86 more
core +1 more source