Results 81 to 90 of about 1,899,131 (352)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Electron-Electron Interactions in Artificial Graphene

Physical Review Letters, 2012
Recent advances in the creation and modulation of graphene-like systems are introducing a science of "designer Dirac materials". In its original definition, artificial graphene is a man-made nanostructure that consists of identical potential wells (quantum dots) arranged in a adjustable honeycomb lattice in the two-dimensional electron gas.
Stefano Pittalis, Stefano Pittalis, Esa Räsänen, Esa Räsänen, Carlo Andrea Rozzi, Giovanni Vignale   +5 more
openaire   +5 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Gyrokinetic electron acceleration in the force-free corona with anomalous resistivity

, 2006
We numerically explore electron acceleration and coronal heating by dissipative electric fields. Electrons are traced in linear force-free magnetic fields extrapolated from SOHO/MDI magnetograms, endowed with anomalous resistivity ($\eta$) in localized ...
Alissandrakis, Amari, Arzner, Arzner, Arzner, Aschwanden, Aschwanden, Aschwanden, Aschwanden, Aulanier, Aulanier, Benz, Benz, Brizard, Chiu, Dmitruk, Dmitruk, Dreicer, Dumont, Fleishman, Fleishman, Fleishman, Fludra, Gallagher, Gary, Georgoulis, Giménez de Castro, Gudiksen, Güdel, K. Arzner, Karimabadi, Koch, Kotov, Kuijpers, L. Vlahos, Lee, Lin, Littlejohn, Littlejohn, Littlejohn, MacLeod, Matthaeus, Nita, Nobile, Parker, Parker, Parker, Petrie, Press, Saint-Hilaire, Schlickeiser, Schumacher, Spicer, Vlahos, Wheatland   +54 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Superconductor coupled to two Luttinger liquids as an entangler for electron spins

, 2001
We consider an s-wave superconductor (SC) which is tunnel-coupled to two spatially separated Luttinger liquid (LL) leads. We demonstrate that such a setup acts as an entangler, i.e. it creates spin-singlets of two electrons which are spatially separated,
A. Aspect, A. Bachthold, A. Einstein, A.F. Volkov, C. Kane, C.H. Bennett, D. Boschi, D. Bouwmeester, D. Loss, D. Rugar, D.D. Awschalom, D.P. DiVincenzo, Daniel Loss, F.D.M. Haldane, F.W.J. Hekking, G. Burkard, G. Burkard, G. Falci, G.B. Lesovik, H.-A. Engel, H.J. Schulz, H.J. Schulz, J. Sólyom, J. Voit, J.M. Kikkawa, J.M. Kikkawa, J.S. Bell, K. Mattle, L. Balents, M. Bockrath, M. Kociak, M.-S. Choi, M.R. Geller, M.R. Geller, P. Recher, P. Recher, Patrik Recher, R. Egger, R. Egger, R. Fazio, R. Heidenreich, Y. Suzumura   +41 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Acceleration, magnetic fluctuations and cross-field transport of energetic electrons in a solar flare loop

, 2011
Plasma turbulence is thought to be associated with various physical processes involved in solar flares, including magnetic reconnection, particle acceleration and transport.
Bickerton, Bykov, Emslie, Galloway, Hannah, Jakimiec, Joshi, Kontar, Liu, Masuda, Petrosian, Prato, Somov, Sui, Temmer, Veronig, Xu   +16 more
core   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source