Precise through-space control of an abiotic electrophilic aromatic substitution reaction
Nature Communications, 2017 Regioselectivity during electrophilic aromatic substitution is typically controlled by substituents on the aryl group. Here the authors report an electrophilic aromatic substitution reaction, wherein remote chiral ester groups direct the electrophile to ...
Kyle E. Murphy +6 more
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Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]
, 2013 The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E. +42 more
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Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group [PDF]
, 2021 Yizhou Zhan, Nan Xiao, Wei Shu
openalex +1 more source
N2H4 as traceless mediator for homo- and cross- aryl coupling
Nature Communications, 2018 Synthesis of biaryls by coupling strategies is unavoidably accompanied by stoichiometric metal waste. Here, the authors report the homo- and cross-electrophile coupling by using hydrazine as metal surrogate, only liberating N2 and H2 as side products.
Leiyang Lv +4 more
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Quantitative determination of the nucleophilicity of allylsilanes [PDF]
, 1989 Kinetic investigations on the reactivity of allylsilanes (1a–o) towards the p-methoxy substituted diphenylcarbenium ion (2) are ...
Hagen, Gisela, Mayr, Herbert
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An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide
CHIMIA, 2014 An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole.
Chantal Belie +15 more
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Electrophilicity Equalization Principle
, 2010 A new electronic structure principle, viz., the principle of electrophilicity equalization is proposed. An analytical justification as well as a numerical support for the same is provided.Comment: 9 pages, 2 ...
Chattaraj, Pratim Kumar +2 more
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Redox Biology, 2019 The intermediate filament protein vimentin constitutes a critical sensor for electrophilic and oxidative stress, which induce extensive reorganization of the vimentin cytoskeletal network.
Andreia Mónico +3 more
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Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]
, 2016 Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A. +4 more
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Crystal Structure of the Chloroplastic Oxoene Reductase ceQORH from Arabidopsis thaliana
Frontiers in Plant Science, 2017 Enzymatic and non-enzymatic peroxidation of polyunsaturated fatty acids give rise to accumulation of aldehydes, ketones, and α,β-unsaturated carbonyls of various lengths, known as oxylipins.
Sarah Mas y mas +5 more
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