Results 101 to 110 of about 22,971 (281)
Organ-specific electrophile responsivity mapping in live C. elegans
Proximity labeling technologies are limited to indexing localized protein residents. Such data—although valuable—cannot inform on small-molecule responsivity of local residents. We here bridge this gap by demonstrating in live C. elegans how electrophile-
Aye, Yimon +7 more
core +2 more sources
, 2020 It is now clear that some cysteines on some proteins are highly tuned to react with electrophiles. Based on numerous studies, it is also established that electrophile sensing underpins rewiring of several critical signaling processes.
Aye, Yimon +8 more
core +1 more source
Angewandte Chemie, EarlyView.Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani +7 more
wiley +2 more sources
Sulphuryl chloride as an electrophile [PDF]
, 1981 The reaction of sulphuryl chloride with a number of anilides in nitromethane at 25 C has been studied kinetically. It was concluded that although molecular sulphuryl chloride, is the major electrophile molecular chlorine also contributes as the attacking
Parand, Simin
core
Synthesis of Arecatannin A1 from Dimeric Epicatechin Electrophile
Natural Product Communications, 2015 Synthesis of arrecatannin A1 (1) was accomplished from dimeric epicatechin electrophile, which was prepared by Zn(OTf) 2 mediated self-condensation, and monomeric catechin nucleophile.
Manato Suda +7 more
doaj +1 more source
, 2020 Cross-electrophile coupling reactions of two Csp3–X bonds remain challenging. Herein we report an intramolecular nickel-catalyzed cross-electrophile coupling reaction of 1,3-diol derivatives. Notably, this transformation is utilized to synthesize a range
Amberly B. Sanford +11 more
core +1 more source
Precise through-space control of an abiotic electrophilic aromatic substitution reaction
Nature Communications, 2017 Regioselectivity during electrophilic aromatic substitution is typically controlled by substituents on the aryl group. Here the authors report an electrophilic aromatic substitution reaction, wherein remote chiral ester groups direct the electrophile to ...
Kyle E. Murphy +6 more
doaj +1 more source
Specific nucleophile-electrophile interactions in nucleophilic aromatic substitutions [PDF]
, 2013 We herein report results obtained from an integrated experimental and theoretical study on aromatic nucleophilic substitution (SNAr) reactions of a series of amines towards 1-fluoro-2,4-dinitrobenzene in water.
Tapia Apati, Ricardo +11 more
core +1 more source
Asymmetric cyanation of imines via dipeptide-derived organophosphine dual-reagent catalysis
Nature Communications, 2016 The Strecker reaction is a power method for the synthesis of cyano-substituted compounds. Here the authors report a dual-reagent system for asymmetric Strecker reactions, where an in situformed organocatalyst/methyl acrylate zwitterionic adduct activates
Hong-Yu Wang +4 more
doaj +1 more source
ELECTROPHILE SIGNALING IN MAMMALIAN AND ZEBRAFISH IMMUNITY AND STRESS RESPONSE
, 2020 299 pagesSupplemental file(s) description: Table A2.3, Table A1.4, Table A1.2.Reactive electrophilic species (RES) have emerged in recent years as bona fide cellular signaling mediators, controlling myriad cellular processes.
Poganik, Jesse Richard
core +1 more source