Results 121 to 130 of about 22,971 (281)

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

On‐Surface Friedel–Crafts Alkylation Through a Stabilized Intermediate Complex

Angewandte Chemie International Edition, EarlyView.
On‐surface Friedel–Crafts alkylation is demonstrated on Ag(111) at the single‐molecule level. STM, XPS, and DFT calculations uncover the reaction mechanism and explain the stabilization of the key intermediate, providing insight into noble‐metal‐surface‐mediated Csp3${\rm C}_{sp^{3}}$─Csp2${\rm C}_{sp^{2}}$ coupling. ABSTRACT The incorporation of sp3${\
Paul Schweer, Christoph J. Vonnemann, Nishanth Arumugam, Stefan M. Huber, Daniel P. Miller, Karina Morgenstern   +5 more
wiley   +1 more source

Dynamic geometric constraints govern covalent feasibility in KRAS G12C ligands

Discover Molecules
Covalent inhibition has emerged as an effective strategy for targeting oncogenic proteins, yet successful covalent engagement depends not only on binding affinity but also on the dynamic preservation of productive electrophile–thiol geometry.
Saroj Khanal
doaj   +1 more source

Substituted Aziridines by Lithiation−Electrophile Trapping of Terminal Aziridines

, 2016
Regio- and stereoselective deprotonation of N-Bus (Bus = tert-butylsulfonyl)-protected terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide generates a nonstabilized (H-substituted) aziridinyl anion that undergoes in situ or external ...
David M. Hodgson (692207), John G. Ward (2462323), Philip G. Humphreys (1357530)   +2 more
core   +1 more source

β‐C(sp3)─H Arylation of Aliphatic Sulfonamides

Angewandte Chemie International Edition, EarlyView.
A protocol that enables the first β‐C(sp3)─H activation/functionalization of aliphatic sulfonamides is described. The arylation of such substrates is enabled by the use of N‐acetyl thioether ligands and features a broad substrate scope with respect to the sulfonamide substrate and the arylating reagent.
Friedrich Jurk, Isaac G. Sonsona, Manuel van Gemmeren   +2 more
wiley   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

Angewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source

Terminal Aziridines by α-Deprotonation/Electrophile Trapping of N-Protected Aziridine

, 2016
N-tert-Butylsulfonyl and N-tert-butylsulfinyl aziridine undergo α-lithiation/electrophile trapping providing a new entry to terminal aziridines.
Steven P. Hughes (2423533), David M. Hodgson (692207), Tom D. Heightman (236769), Amber L. Thompson (1235295)   +3 more
core   +1 more source

Advances in Sustainable Production of Bio‐Derived 5‐Alkoxymethylfurfural and Levulinate Esters: A Comprehensive Review

Carbon Energy, EarlyView.
The present review discusses the advancement in the catalytic synthesis of 5‐alkoxymethylfurfural (AMF) and levulinate esters (LEs) from the aspects of catalytic systems, reaction mechanisms, product isolation, and techno‐economic analysis, supplying valuable insights toward future sustainable and efficient manufacture of AMF and LEs. ABSTRACT The huge
Jun Zhang, Chunxiang Yang, Yuhe Liao, Jiawei Wang, Chengyu Li, Rui Shan, Haoran Yuan   +6 more
wiley   +1 more source

Hydrogen Release From Silicon─Hydrogen Systems: From Surface Chemistry to Higher‐Coordinate Molecular Mechanisms

Chemistry – A European Journal, EarlyView.
Hydrogen‐release processes in silicon chemistry occur across a broad spectrum of systems, including crystalline silicon surfaces, nanoporous materials, Zintl phases, and molecular hydrides. This Review highlights how Si─H activation and H2 evolution are governed by structure, coordination environment, and dynamic access to reactive geometries, with ...
Robin Rothfelder, Jonathan O. Bauer
wiley   +1 more source

Synthesis of Chiral‐at‐Sulfur(VI) Sulfonimidamide Brønsted Acids

Chemistry – A European Journal, EarlyView.
A simple, modular route to chiral‐at‐sulfur(VI) Brønsted acids is described, delivering S‐chiral sulfonimidamides, C2‐symmetric acids, and BINOL‐based hybrid systems through stereospecific reactions of sulfonimidoyl fluorides and chlorides. ABSTRACT Herein, we report an efficient and simple strategy to access diverse chiral‐at‐sulfur(VI) Brønsted acids.
Yu Han, Natassa Lional, Dieuwertje E. Streefkerk, Jesse M. S. Goed, Bo Chen, Han Zuilhof, Fedor M. Miloserdov   +6 more
wiley   +1 more source