Results 131 to 140 of about 43,957 (340)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Mapping of Some Further Alkylation-Initiated Pathways to Polyheterocyclic Compounds from Indigo and Indirubin

Molecules
The reaction of indigo with two equivalents of the electrophile ethyl bromoacetate with caesium carbonate as a base result in the formation of structurally complex polyheterocyclics, including a fused spiroimidazole and a spiro[1,3]oxazino derivative ...
Sarfaraz Ali, Patrick M. McCosker, Anthony C. Willis, Stephen G. Pyne, Christopher Richardson, John B. Bremner, Paul A. Keller   +6 more
doaj   +1 more source

1,2-Bis(azol-1-yl)ethanes. Deprotonation and Subsequent Reaction with Electrophiles.

, 1996
Enrique Dı́ez-Barra, Antonio Herrera, Antonio de la Hoz, Juan Tejeda   +3 more
openalex   +1 more source

Difunctionalization of C–C σ-Bonds Enabled by the Reaction of Bicyclo[1.1.0]butyl Boronate Complexes with Electrophiles: Reaction Development, Scope, and Stereochemical Origins

, 2020
Steven H. Bennett, Alexander Fawcett, Elliott H. Denton, Tobias Biberger, Valerio Fasano, Nils Winter, Varinder K. Aggarwal   +6 more
openalex   +2 more sources

Borylation Directed Borylation of Indoles Using Pyrazabole Electrophiles: A One‐Pot Route to C7‐Borylated‐Indolines [PDF]

, 2022
Jürgen Pahl, Emily Noone, Marina Uzelac, Kang Yuan, Michael J. Ingleson   +4 more
openalex   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, EarlyView.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Amines vs. N-Oxides as Organocatalysts for Acylation, Sulfonylation and Silylation of Alcohols: 1-Methylimidazole N-Oxide as an Efficient Catalyst for Silylation of Tertiary Alcohols [PDF]

, 2015
Murray, JI, Spivey, AC
core   +1 more source

New Horizons in C-F Activation by Main Group Electrophiles (Final Technical Report)

, 2014
Oleg V. Ozerov
openalex   +2 more sources

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Kinetics of the reactions of laser-flash photolytically generated carbenium ions with alkyl and silyl enol ethers. Comparison with the reactivity toward alkenes, allylsilanes and alcohols [PDF]

, 1991
Bartl, Joerg, Mayr, Herbert, Steenken, Steen   +2 more
core   +1 more source