Results 141 to 150 of about 43,957 (340)
Structure−Activity Analysis of Diffusible Lipid Electrophiles Associated with Phospholipid Peroxidation: 4-Hydroxynonenal and 4-Oxononenal Analogues [PDF]
, 2011 Colleen E. McGrath +3 more
openalex +1 more source
Chemistry – A European Journal, EarlyView.A readily accessible, air‐ and moisture‐stable palladium precatalyst, [Pd(1‐MeNAP)(tBuBrettPhos)]OTf, enables the direct N‐arylation of NH‐sulfoximines with (hetero)aryl chlorides under exceptionally mild conditions ideal for late‐stage diversification of drug‐like scaffolds.
Sourav Manna +5 more
wiley +1 more source
Ligand Relay for Nickel‐Catalyzed Decarbonylative Alkylation of Aroyl Chlorides
Advanced ScienceTransition metal‐catalyzed direct decarboxylative transformations of aromatic carboxylic acids usually require high temperatures, which limit the substrate's scope, especially for late‐stage applications.
Tian‐Zhang Wang +3 more
doaj +1 more source
Expedient Discovery of a Metallaphotoredox Cyanomethylation for Synthesizing α‐Aryl Nitriles
Chemistry – A European Journal, EarlyView.A metallaphotoredox cyanomethylation reaction has been developed for the synthesis of valuable α‐aryl nitrile intermediates. The methodology was successfully applied to diverse medicinally‐relevant substrates, providing an expedient route to anti‐cancer Senexin compounds, while also removing the need for toxic cyanide reagents. The mechanism was probed
Gemma C. Cook +6 more
wiley +1 more source
Nickel‐Catalyzed Cross‐Coupling of Organolithium Reagents with (Hetero)Aryl Electrophiles
, 2015 Dorus Heijnen +3 more
openalex +2 more sources
Chemistry – A European Journal, EarlyView.Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis +2 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.This work introduces the concept of pseudoglucosinolates (psGSLs) and reports the synthesis and evaluation of nitroreductase‐responsive psGSLs. These compounds represent a complementary prodrug strategy to natural glucosinolates (GSLs) for the controlled release of isothiocyanates (ITCs), enabling bio‐responsive protein labeling, as demonstrated in ...
Claire C. Jimidar +13 more
wiley +1 more source