Results 221 to 230 of about 43,957 (340)

Covalent aptamers: agents with promising therapeutic and diagnostic potential. [PDF]

RSC Chem Biol
Albright S, Boette J, Cacace M, Deiters A.   +3 more
europepmc   +1 more source

Neuartige Methoden zur benzylischen Funktionalisierung von Phthalan-Cr(CO)3-Komplexen und deren Anwendung in der stereoselektiven Synthese von cis- und trans-1,3-disubstituierten Dihydroisobenzofuranen [PDF]

, 2003
Zemolka, Saskia
core  

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

DNA-Protein Cross-Link Formation and Cellular Toxicity by Chimeric Bis-Electrophiles. [PDF]

J Org Chem
Yu H, Jiang X, Greenberg MM.
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Electrochemically cooperative halogen-cation delivery enables modular electrophilic haloesterification of both activated and unactivated alkenes. [PDF]

Chem Sci
Xu HH, Qian DD, Fan Y, Zhang JJ, Guo CL, Xu HC.   +5 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Heterobenzyl Chlorides as Linchpins for C-H Arylation via Sequential C-H Chlorination/Cross-Electrophile Coupling. [PDF]

ACS Catal
Floreancig JT, Lopez MA, Dick AR, Cardinale L, Goodwin NC, Poole DL, Stahl SS.   +6 more
europepmc   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Unveiling the reaction mechanism and the regioselectivity of Diels-Alder cycloadditions between 2-methoxy-3-thiophenylbutadiene and methyl vinyl ketone using topological tools. [PDF]

RSC Adv
Chellegui M, Mohammed Salih SA, Benhamed L, Mohammad-Salimd HA, Ben Ahmed A.   +4 more
europepmc   +1 more source