Results 141 to 150 of about 222,058 (260)

Design and Evaluation of Sticky End‐Type Bivalent DNA Aptamers Containing M08s‐1 as Anticoagulant Agents

ChemMedChem, EarlyView.
Sticky end‐type antithrombin aptamer, composed of two short hybridizable segments, is developed as a potential alternative to conventional anticoagulant drugs. The obtained bivalent aptamer surpasses existing long bivalent aptamers in anticoagulant activity and serum stability, offering advantages in synthesis efficiency and cost‐effectiveness. Aptamer
Maasa Yokomori, Mizuki Murasawa, Muneyuki Matsuo, Masanobu Nagano, Keitaro Yoshimoto   +4 more
wiley   +1 more source

Harnessing Synergies between Combinatorial Microfluidics and Machine Learning for Chemistry, Biology, and Fluidic Design

Chemistry–Methods, EarlyView.
This review explores the synergy of combinatorial microfluidics and machine learning, highlighting their transformative impact on high‐throughput experimentation, closed‐loop reaction optimization, and autonomous platform development. Key applications in chemical synthesis, biological research, and microfluidic design are discussed, addressing ...
Suyash S. Damir, Julie Probst, Andrew deMello, Stavros Stavrakis   +3 more
wiley   +1 more source

Alpha-Thalassemia Unmasked in a Patient With Sickle Cell Trait: A Case Report. [PDF]

Cureus
Chuquimarca B, Carrión C, Matosas V, Riva E.   +3 more
europepmc   +1 more source

Pigment‐Macromolecule Complexes Isolation from Sea Urchin Biomineral Waste for Coloring Materials

Chemistry–Methods, EarlyView.
A methodology has been developed to extract the colored organic fraction occluded within seashell biomineral waste. Applied to sea urchin skeletons, free polyhydroxylated naphthoquinone (PHNQ) pigments and PHNQ‐macromolecule complexes are isolated. These complexes show superior pH stability in purple hues compared to free PHNQ, which shifts from red to
Claudio Ferreira, Vaskar Sardhalia, Alshaba Kakar, Romain Descamps, Lucrèce Matheron, François Ribot, Alexandre Disser, Tony Jouanneau, Elena Vasileva, Natalia Mishchenko, Nadine Nassif, Frédéric Marin, Marie Albéric   +12 more
wiley   +1 more source

Dynamic monitoring of M-protein quantification by immunotyping using capillary zone electrophoresis during the chemotherapy of patients with multiple myeloma. [PDF]

Sci Rep
Jia Z, Lu Q.
europepmc   +1 more source

Following Changes at the Solid/Liquid Interface for Large Microplastic Particles by Streaming Potential

Chemistry–Methods, EarlyView.
The surface chemistry of commercial, fragmented, and artificially weathered microplastic particles is characterized by the streaming potential technique. The streaming potential technique allows to study the zeta‐potential of particles too big for electrophoretic mobility.
Matthias B. Engelhardt, Daniel Wagner, Mohsen Zarebanadkouki, Nora Meides, Christian Schulbert, Martin G. J. Löder, Nicolas Helfricht, Seema Agarwal, Andrea Carminati, Peter Strohriegl, Jürgen Senker, Christian Laforsch, Georg Papastavrou   +12 more
wiley   +1 more source

Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers

Drug Testing and Analysis, EarlyView.
Exogenous T was detected with IRMS regardless of T/E elevation—high serum T indicative for IRMS. rhEPO was detected in urine for 72 h in ITP and CP, and Tasso showed less sensitivity than previous DBS devices tested. ABSTRACT Doping with testosterone (T) and erythropoietin (EPO) in low doses (micro‐doping) is a challenge to detect.
Carmel Heiland, Oscar Hopcraft, Mats Johanson, Anton Pohanka, Mikael Lehtihet, Lena Ekström   +5 more
wiley   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, EarlyView.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

Ion-exchange chromatography, capillary isoelectric focusing, and capillary zone electrophoresis coupled to mass spectrometry for charge variant analysis of monoclonal antibodies. [PDF]

MAbs
Schairer J, Höchsmann A, Bauer B, Höfer V, Römer J, Neusüß C.   +5 more
europepmc   +1 more source

CERA Detection and Stability in Blood Versus Urine

Drug Testing and Analysis, EarlyView.
This study presents comparative data on CERA detection in serum and urine samples, highlighting adverse analytical findings (AAFs) in serum that were undetected in corresponding urine samples. This shift would significantly improve the efficiency and sensitivity of CERA detection in doping control, ensuring more effective doping control programs ...
Olivier Salamin, Joséphine Chappuis, Lasse V. Bækken, Tiia Kuuranne, Nicolas Leuenberger   +4 more
wiley   +1 more source