Results 191 to 200 of about 820,083 (349)

Real‐Time Eco–AI, Electrophoresis‐Correlative Data‐Dependent Acquisition with AI‐Based Data Processing Broadens Access to Single‐Cell Mass Spectrometry Proteomics

Angewandte Chemie, EarlyView.
An affordable single‐cell proteomics workflow combines capillary electrophoresis, real‐time ion sorting, and AI‐aided spectral deconvolution to profile early Xenopus embryonic cells. Despite using a legacy Orbitrap, this strategy matches or exceeds the sensitivity of modern instruments, uncovering proteome dynamics at sub‐nanogram scale.
Bowen Shen, Fei Zhou, Peter Nemes
wiley   +2 more sources

Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method. [PDF]

PLoS One
Chen W.
europepmc   +1 more source

Capillary Electrophoresis in Nanotechnologies versus Nanotechnologies in Capillary Electrophoresis

, 2018
Vojtech Adam, Marketa Vaculovicova
openaire   +3 more sources

Genotype–Phenotype Correlations, Mortality, and Clinical Insights in Keratitis–Ichthyosis–Deafness Syndrome: A Comprehensive Review and Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Keratosis–ichthyosis–deafness (KID) syndrome is a rare autosomal dominant ectodermal disease caused by mutations in the GJB2 gene, which encodes the gap junction protein Connexin 26 (Cx26) located on Chr. 13q12.11. This study presents the first mortality analysis associated with KID syndrome, focusing on a case report of a Latin American ...
Leslie Patrón‐Romero, Marco Antonio Hernández Lepe, José de Jesús Manríquez Torres, Diego Daniel Aguirre‐Gómez, Natsuo Hayashi‐Mercado, Genaro Rodríguez Uribe, Tadeo Cerón, María Ruiz‐Gamboa, Jesús Alonso Gándara‐Mireles, Ismael Lares‐Asseff, Verónica Loera‐Castañeda, Jorge Alvelais‐Palacios, Lucrecia Arzamendi‐Cepeda, Lidia Magdalena Castañeda‐González, Adolfo García‐Barrón, Francisco Yamal Quiroz Herrera, Francisco González‐Salazar, Horacio Almanza‐Reyes   +17 more
wiley   +1 more source

Accelerating Characterization of Therapeutic Antibodies: A Comparative Assessment of icIEF-UV/MS and the Traditional Fractionation Workflow. [PDF]

J Am Soc Mass Spectrom
Shah A, Shah P, Johnson A, Bender J, Gumerov D, Ding J, Mack S, Stone MD, Ostrowski MA.   +8 more
europepmc   +1 more source

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang, Yufei Li, Lin Zhang, Zhaoqing Li, Keqin Lin, Kai Huang, Zhaoqing Yang, Shaohui Ma, Hao Sun, Xiaochao Zhang   +9 more
wiley   +1 more source

Frontier Technologies in Single-Cell Analysis: Synergistic Fusion of Droplet Printing and High-Performance Detection System. [PDF]

Anal Sci Adv
Zhang Q, Li J, Zhang Y, Zhang H, Wang C, Ma Q.   +5 more
europepmc   +1 more source

Development, validation, and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

Animal Models and Experimental Medicine, EarlyView.
Deleting Col6a3 exon 3 by CRISPR in mice results in centralized nuclei consistent with a myopathy phenotype mimicking collagen VI‐associated human disease Abstract Background Most mutations in the COL6A3 gene lead to collagen VI‐related myopathies. This is due to a reduced expression or mislocalization of the COL6A3 protein.
Michel ElChoueiry, Harsimran Sidhu, Maude Lévesque, Dominique Lévesque, Jean‐François Jacques, Otman Sarrhini, Jean‐François Beaudoin, Molly Caron, Brenda Gaudette, Roger Lecomte, Xavier Roucou, François‐Michel Boisvert, Jean‐Philippe Brosseau   +12 more
wiley   +1 more source

Unveiling Rare Hemoglobinopathies: Hematologic Characterization of Double Heterozygous Hb D and Hb E With Beta-Thalassemia-A Case Report. [PDF]

Case Rep Hematol
Minhas AM, Eiman H, Iqbal J, Imran A, Chughtai AS.   +4 more
europepmc   +1 more source

Recent applications of on-line sample preconcentration techniques in capillary electrophoresis.

Journal of Chromatography A, 2014
F. Kitagawa, K. Otsuka
semanticscholar   +1 more source