Results 141 to 150 of about 212,609 (265)

A spatially confined "double-key lock" smart DNA hydrogel for dynamic detection of MicroRNA in cells. [PDF]

Chem Sci
Shi L, Liang D, Kuang J, He Y, Wang D, Shan J, Wang Z, Shen W, Lee HK, Tang S.   +9 more
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Isolation protocol for two-dimensional-polyacrylamide gel electrophoresis analysis of Haloferax volcanii proteome

BioTechniques, 2003
Edward C. Evans, Troy Horn, Mary Ann Wagner, Michel Eschenbrenner, Cesar V. Mujer, Vito G. DelVecchio   +5 more
doaj   +1 more source

Identification of highly cross-reactive immunogens in Eimeria tenella sporozoites. [PDF]

Parasite
Chen W, Han T, Song F, Zhang H, Wang X, Gong H, Liu L.   +6 more
europepmc   +1 more source

Laboratory Course on High Resolution Two Dimensional Gel Electrophoresis Of Proteins

semanticscholar   +1 more source

Internal amino acid sequence analysis of proteins separated by one- or two-dimensional gel electrophoresis after in situ protease digestion on nitrocellulose.

Proceedings of the National Academy of Sciences of the United States of America, 1987
R. Aebersold, J. Leavitt, R. Saavedra, L. Hood, S. Kent   +4 more
semanticscholar   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Cooperativity, entropy, and effective concentration in DNA origami self-replication. [PDF]

Sci Adv
Ni H, Zhou F, Zhu G, Bershadsky L, Ai S, Wang K, Sha R, Seeman NC, Chaikin PM.   +8 more
europepmc   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Proteomic analysis of proteins responsive to drought stress in barley. [PDF]

BMC Plant Biol
Ramadan WA, Mahmoud FE, Abou-Deif MH, Ali M.   +3 more
europepmc   +1 more source