Results 51 to 60 of about 1,414,906 (307)

Stochastic modeling for the COMET-assay [PDF]

, 2003
We present a stochastic model for single cell gel electrophoresis (COMET-assay) data. Essential is the use of point process structures, renewal theory and reduction to intensity histograms for further data ...
Boulesteix, Anne-Laure, Hösel, V., Liebscher, V.   +2 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Rapid Microchip Electrophoretic Separation of Novel Transcriptomic Body Fluid Markers for Forensic Fluid Profiling

Micromachines, 2022
Initial screening of criminal evidence often involves serological testing of stains of unknown composition and/or origin discovered at a crime scene to determine the tissue of origin. This testing is presumptive but critical for contextualizing the scene.
Tiffany R. Layne, Renna L. Nouwairi, Rachel Fleming, Haley Blair, James P. Landers   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Capillary electrophoresis characterisation of a rapid prototyped PMMA chip for particle analysis [PDF]

, 2010
Màster en Nanociència i NanotecnologiaA rapid and cheap method has been developed for the fabrication of a capillary electrophoresis chip for the preliminary characterization of particles.
Colom, Adai
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Computer Aided Simulation of DNA Fingerprint Amplified Fragment Length Polymophism (AFLP) Using Suffix Tree Indexing and Data Mining [PDF]

, 2011
AFLP is one of the DNA Fingerprinting techniques which have broad application as genetic marker in various fields. Begin with the DNA sequence digestion using one or more particular restriction enzyme, ligation of the adapters to the overhanging sticky ...
Budiman, Agung, Prilianti, Kestrilia Rega, Putra, Sulistyo Emantoko Dwi, Whendy, Bhinawan   +3 more
core  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Avaliação do perfil eletroforético das proteínas séricas em matrizes pesadas (Gallus Gallus Domesticus) da linhagem Avian Farm Serum protein electrophoresis evaluation in adult broiler breeders (Gallus Gallus Domesticus) of the Avian Farm strain

Brazilian Journal of Poultry Science, 2002
O objetivo do presente trabalho foi determinar o perfil eletroforético das proteínas séricas em matrizes pesadas (Gallus Gallus Domesticus) sadias, da linhagem Avian Farm. Foram utilizadas 15 matrizes com 63 semanas de idade, provenientes do município de
MY Hasegawa, JH Fonteque, A Kohayagawa, LP Boretti   +3 more
doaj   +1 more source

Mesoscale modelling of polyelectrolyte electrophoresis

, 2009
The electrophoretic behaviour of flexible polyelectrolyte chains ranging from single monomers up to long fragments of hundred repeat units is studied by a mesoscopic simulation approach.
Ahlrichs, Antypov, Antypov, Barrat, Belloni, Belloni, Christian Holm, Cottet, Cottet, Deserno, Deserno, Dolnik, Grass, Grass, Grass, Hoagland, Kai Grass, Limbach, Limbach, Lobaskin, Long, Manning, McNamara, Mohanty, Moore, Muthukumar, Oosawa, Slater, Soddemann, Tanaka, Volkel, Weeks, Wette, Wolff   +33 more
core   +2 more sources